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Q2G9R1

- SYE1_NOVAD

UniProt

Q2G9R1 - SYE1_NOVAD

Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Novosphingobium aromaticivorans (strain DSM 12444 / F199)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei243 – 2431ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNARO279238:GHBU-980-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetase 1UniRule annotation
    Short name:
    GluRS 1UniRule annotation
    Gene namesi
    Name:gltX1UniRule annotation
    Ordered Locus Names:Saro_0967
    OrganismiNovosphingobium aromaticivorans (strain DSM 12444 / F199)
    Taxonomic identifieri279238 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium
    ProteomesiUP000009134: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Glutamate--tRNA ligase 1PRO_0000237380Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi279238.Saro_0967.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2G9R1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi9 – 1911"HIGH" regionAdd
    BLAST
    Motifi240 – 2445"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000252721.
    KOiK01885.
    OMAiRIALFNW.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2G9R1-1 [UniParc]FASTAAdd to Basket

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    MATVTRFAPS PTGKLHVGNV RTALHNWLLA KKTGGRFLLR IDDTDAERSR    50
    EEYVESIRAD LQWLGLIPDG EERQSLRTEL YEREFQRLVE AGRIYRAYET 100
    AQELDLKRKI LLGRGLPPIY DRAALKLTEA DHAAKAAAGE RPHWRFLLDH 150
    DQPITWDDGI RGPQSFDPRQ MSDPVIRRAD GSWLYMLPSA IDDIAMGITD 200
    VLRGEDHVSN TATQIQMFTA LGAEPPRFAH EALLTGSEGK LSKRLGALGM 250
    ADFREQGIEP EAIVALLARL GTSDPVDAAL DAAALATSFD LSRFGRAPAR 300
    FDEADLHRVN AQIVHRLPYA RVAHLLPQGM GEAAWEAIRP NLAHIDEARD 350
    WWNVVTGPVT APTFDDETRA FLAQAAKTAA SLDWSADPWR ALTATLKDGT 400
    GRKGKALFLP LRQALTGHDH GPEMAALLPL IAQDEAVRRL SA 442
    Length:442
    Mass (Da):48,922
    Last modified:March 21, 2006 - v1
    Checksum:i841180C310E17DF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000248 Genomic DNA. Translation: ABD25412.1.
    RefSeqiYP_496246.1. NC_007794.1.

    Genome annotation databases

    EnsemblBacteriaiABD25412; ABD25412; Saro_0967.
    GeneIDi3915749.
    KEGGinar:Saro_0967.
    PATRICi22784560. VBINovAro50627_0986.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000248 Genomic DNA. Translation: ABD25412.1 .
    RefSeqi YP_496246.1. NC_007794.1.

    3D structure databases

    ProteinModelPortali Q2G9R1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 279238.Saro_0967.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD25412 ; ABD25412 ; Saro_0967 .
    GeneIDi 3915749.
    KEGGi nar:Saro_0967.
    PATRICi 22784560. VBINovAro50627_0986.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000252721.
    KOi K01885.
    OMAi RIALFNW.
    OrthoDBi EOG6DRPF7.

    Enzyme and pathway databases

    BioCyci NARO279238:GHBU-980-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 12444 / F199.

    Entry informationi

    Entry nameiSYE1_NOVAD
    AccessioniPrimary (citable) accession number: Q2G9R1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3