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Q2G933

- ASSY_NOVAD

UniProt

Q2G933 - ASSY_NOVAD

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Protein
Argininosuccinate synthase
Gene
argG, Saro_1195
Organism
Novosphingobium aromaticivorans (strain DSM 12444 / F199)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei90 – 901Citrulline By similarity
Binding sitei95 – 951Citrulline By similarity
Binding sitei120 – 1201ATP; via amide nitrogen By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei126 – 1261Aspartate By similarity
Binding sitei126 – 1261Citrulline By similarity
Binding sitei127 – 1271Aspartate By similarity
Binding sitei130 – 1301Citrulline By similarity
Binding sitei181 – 1811Citrulline By similarity
Binding sitei190 – 1901Citrulline By similarity
Binding sitei266 – 2661Citrulline By similarity
Binding sitei278 – 2781Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNARO279238:GHBU-1210-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Saro_1195
OrganismiNovosphingobium aromaticivorans (strain DSM 12444 / F199)
Taxonomic identifieri279238 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium
ProteomesiUP000009134: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Argininosuccinate synthaseUniRule annotation
PRO_0000263946Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi279238.Saro_1195.

Structurei

3D structure databases

ProteinModelPortaliQ2G933.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2G933-1 [UniParc]FASTAAdd to Basket

« Hide

MSDIKKVVLA YSGGLDTSVI LKWLQVTYNC EVVTFTADLG QGEELEPARA    50
KAKLMGVPDH HIYIDDLREE FVRDFVFPMM RANARYEGDY LLGTSIARPL 100
ISKRLIEIAR ETGADAVAHG ATGKGNDQVR FELSAYALEP GIKVIAPWRE 150
WDLTSRTALI AWAEAHQIPV PKDKRGESPF STDANLLHTS SEGKVLEDPW 200
QETPDYVYSR TVNPEDAPDT PEYITIDFEK GDGVALNGEA MSPATLLAAL 250
NDLGRKHGIG RLDLVENRFV GMKSRGMYET PGGEIYARAH RGIESITLDR 300
GAAHLKDELM PKYAELIYNG FWFSPEREML QAAIDHSQAR VNGTVRLKLY 350
KGSASVVGRK SPDSLYSERH VTFEDDAGAY DQKDAAGFIK LNALRLRLLA 400
QQGR 404
Length:404
Mass (Da):44,929
Last modified:March 21, 2006 - v1
Checksum:i0E058A6D35FA4A0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000248 Genomic DNA. Translation: ABD25640.1.
RefSeqiWP_011444854.1. NC_007794.1.
YP_496474.1. NC_007794.1.

Genome annotation databases

EnsemblBacteriaiABD25640; ABD25640; Saro_1195.
GeneIDi3916492.
KEGGinar:Saro_1195.
PATRICi22785032. VBINovAro50627_1220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000248 Genomic DNA. Translation: ABD25640.1 .
RefSeqi WP_011444854.1. NC_007794.1.
YP_496474.1. NC_007794.1.

3D structure databases

ProteinModelPortali Q2G933.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279238.Saro_1195.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD25640 ; ABD25640 ; Saro_1195 .
GeneIDi 3916492.
KEGGi nar:Saro_1195.
PATRICi 22785032. VBINovAro50627_1220.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci NARO279238:GHBU-1210-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12444 / F199.

Entry informationi

Entry nameiASSY_NOVAD
AccessioniPrimary (citable) accession number: Q2G933
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 21, 2006
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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