Q2G7C4 (G6PI_NOVAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	Saro_1809

Organism

Novosphingobium aromaticivorans (strain DSM 12444) [Complete proteome] [HAMAP]

Taxonomic identifier

279238 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Novosphingobium

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000252632
Sites
	Active site	337	1	Proton donor By similarity
	Active site	368	1	By similarity
	Active site	478	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2G7C4 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: F9DFF60CDE1C7A18	FASTA	507	53,414
	10 20 30 40 50 60 MTVAEAETYW TALAGLPRPT LKELFSDAGR LDRYAATLDL PGGPIRFDWS KTHLSAEVEA 70 80 90 100 110 120 VFAALASAMD FEGRRAALIE GAKINNTEGR AAEHTAQRGI GNEASVEEAE ALHARMRMLV 130 140 150 160 170 180 DAIHAGALGE VRSLIHIGIG GSALGPALAI DALTRDGAKV AVHVVSNIDG CALEAAMKAC 190 200 210 220 230 240 DPATTMIAVA SKTFTTTETM TNAASALEWL RENGVADPYG QVVALTAAPE KAVEWGVDET 250 260 270 280 290 300 RVLPFSETVG GRYSLWSSIG FPVAMALGWE GFAAFLDGAA AIDRHFIDAD LAGNVVVRAA 310 320 330 340 350 360 FADLYYTQVR GCQTRAVFAY DERLALLPDY LQQLEMESNG KRVLADGSPL TRPSAPVTWG 370 380 390 400 410 420 GVGTDAQHAV FQLLHQGTHL IPVDFLAVKT QGHDLDPAHH QILLSNCFAQ GAALMAGKAS 430 440 450 460 470 480 DDGARAYPGD RPSATILCDD LNPATLGALI AFHEHRTFVS AVMLGINPFD QFGVELGKAI 490 500 AKQIESGGGE GFDPSTEALL AAVGLAG

References

[1]

"Complete sequence of Novosphingobium aromaticivorans DSM 12444." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N. , Fredrickson J., Balkwill D., Romine M.F., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 12444.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000248 Genomic DNA. Translation: ABD26249.1.
RefSeq	YP_497083.1. NC_007794.1.
3D structure databases
HSSP	HSSP built from PDB template 2CXN based on UniProtKB Q3TEE7.
ProteinModelPortal	Q2G7C4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2G7C4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3918368.
GenomeReviews	Gene locus Saro_1809 in contig CP000248_GR.
KEGG	nar:Saro_1809.
NMPDR	fig|48935.1.peg.1343.
PATRIC	22786306. VBINovAro50627_1848.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG352954.
OMA	ASIWDIN.
PhylomeDB	Q2G7C4.
ProtClustDB	PRK00179.
Enzyme and pathway databases
BioCyc	NARO279238:SARO_1809-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_NOVAD

Accession

Primary (citable) accession number: Q2G7C4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program