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Q2G781 (GCSPA_NOVAD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Saro_1852
OrganismNovosphingobium aromaticivorans (strain DSM 12444 / F199) [Complete proteome] [HAMAP]
Taxonomic identifier279238 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 452452Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000045672

Sequences

Sequence LengthMass (Da)Tools
Q2G781 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: BCD17DC65E74DCFA

FASTA45247,592
        10         20         30         40         50         60 
MRYLPLTDAD RSAMLSVVGA GSVDELFADV PAEARLSAPI AGLPNHASEM AVERHMARLS 

        70         80         90        100        110        120 
ANNVTAGSVP FFLGAGAYRH HVPATVDHMI QRGEFLTAYT PYQPEIAQGT LQVLFEFQTQ 

       130        140        150        160        170        180 
VARLFGTDVA NASLYDGSTA CWEAIAMAGR ITKRGKALLS GGLHPHYVET ARTMARFTGD 

       190        200        210        220        230        240 
VLDTSAPVLT AAPDDDALVA RIDGETSCVV VQYPDILGRI PDLAKIAAAA QAQGALLITV 

       250        260        270        280        290        300 
VTEPVALGVL QSPGSLGADI VVGEGQSLGV GLQFGGPYLG LFGCREKYLR QIPGRLCGET 

       310        320        330        340        350        360 
VDADGKRGFV LTLSTREQHI RREKATSNIC TNSGLCALAF SIHLTLLGGS GLADMARLSH 

       370        380        390        400        410        420 
LAARKTAAAL AQVSGIEVVN SHFFNEFTVA LPHDARQIVR DLADRHVLGG VSLGRLYPQE 

       430        440        450 
AALANGMVVA ATECTTDEDI AALVAALKEV LA 

« Hide

References

[1]"Complete sequence of Novosphingobium aromaticivorans DSM 12444."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N. expand/collapse author list , Fredrickson J., Balkwill D., Romine M.F., Richardson P.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 12444 / F199.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000248 Genomic DNA. Translation: ABD26292.1.
RefSeqYP_497126.1. NC_007794.1.

3D structure databases

ProteinModelPortalQ2G781.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING279238.Saro_1852.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD26292; ABD26292; Saro_1852.
GeneID3918414.
KEGGnar:Saro_1852.
PATRIC22786398. VBINovAro50627_1894.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycNARO279238:GHBU-1880-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_NOVAD
AccessionPrimary (citable) accession number: Q2G781
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families