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Q2G718

- TRMFO_NOVAD

UniProt

Q2G718 - TRMFO_NOVAD

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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene
trmFO, Saro_1915
Organism
Novosphingobium aromaticivorans (strain DSM 12444 / F199)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146FAD By similarity

GO - Molecular functioni

  1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciNARO279238:GHBU-1945-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO (EC:2.1.1.74)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferase
Folate-dependent tRNA(M-5-U54)-methyltransferase
Gene namesi
Name:trmFO
Ordered Locus Names:Saro_1915
OrganismiNovosphingobium aromaticivorans (strain DSM 12444 / F199)
Taxonomic identifieri279238 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium
ProteomesiUP000009134: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotationPRO_0000346369Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279238.Saro_1915.

Structurei

3D structure databases

ProteinModelPortaliQ2G718.

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.

Phylogenomic databases

eggNOGiCOG1206.
HOGENOMiHOG000252054.
KOiK04094.
OMAiEIYFEGC.
OrthoDBiEOG6J74VT.

Family and domain databases

HAMAPiMF_01037. TrmFO.
InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
PROSITEiPS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2G718-1 [UniParc]FASTAAdd to Basket

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MTHQVHIIGG GMAGTEAAWQ LARRGIRVRL SEMRGGGDTT PAHNGDGLAE    50
LVCSNSFRSD DDEKNAVGLL HYEMRQCDSL LMAAAAKARV PAGSALAVDR 100
DVFSAEVEAA LRAQPTLEIV RERVDVLPSD GLTIVATGPL TAPSLANSIG 150
SATGADSLAF FDAIAPIVYR DSIDMGVAWM ASRWDKGAEA SLAMGGDGRD 200
YINCPMTRDQ YLAFREELLA GEKTEFKEWE ANTPYFDGCM PIEVMAARGE 250
ETLRFGPMKP VGLDNPHWAT AEHPNGRWPY AVVQLRQDNK LGTLWNMVGF 300
QTKLKHAEQV RVFRTIPGLE NAEFARLGGL HRNTFLNSPT LLDRQLRLKS 350
APNVRFAGQI TGCEGYVESG SVGMLAGLMV AAQIAGLDWS PPPRTTALGA 400
LLAHITGDAE AESFQPMNVN FGLFSPVDAS VKKKVRKEAY TARAKADLSD 450
WIATLA 456
Length:456
Mass (Da):49,316
Last modified:March 21, 2006 - v1
Checksum:i22DA550E6F24509F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000248 Genomic DNA. Translation: ABD26355.1.
RefSeqiWP_011445565.1. NC_007794.1.
YP_497189.1. NC_007794.1.

Genome annotation databases

EnsemblBacteriaiABD26355; ABD26355; Saro_1915.
GeneIDi3917138.
KEGGinar:Saro_1915.
PATRICi22786536. VBINovAro50627_1961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000248 Genomic DNA. Translation: ABD26355.1 .
RefSeqi WP_011445565.1. NC_007794.1.
YP_497189.1. NC_007794.1.

3D structure databases

ProteinModelPortali Q2G718.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279238.Saro_1915.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD26355 ; ABD26355 ; Saro_1915 .
GeneIDi 3917138.
KEGGi nar:Saro_1915.
PATRICi 22786536. VBINovAro50627_1961.

Phylogenomic databases

eggNOGi COG1206.
HOGENOMi HOG000252054.
KOi K04094.
OMAi EIYFEGC.
OrthoDBi EOG6J74VT.

Enzyme and pathway databases

BioCyci NARO279238:GHBU-1945-MONOMER.

Family and domain databases

HAMAPi MF_01037. TrmFO.
InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view ]
Pfami PF01134. GIDA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
PROSITEi PS01281. GIDA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12444 / F199.

Entry informationi

Entry nameiTRMFO_NOVAD
AccessioniPrimary (citable) accession number: Q2G718
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 21, 2006
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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