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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CIP 105152 / NBRC 16084 / F199)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (Saro_0432)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37SubstrateUniRule annotation1
Binding sitei116SubstrateUniRule annotation1
Binding sitei149SubstrateUniRule annotation1
Binding sitei199ATPUniRule annotation1
Binding sitei322ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi352 – 355ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNARO279238:G1G5T-1991-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:Saro_1965
OrganismiNovosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CIP 105152 / NBRC 16084 / F199)
Taxonomic identifieri279238 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium
Proteomesi
  • UP000009134 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000580231 – 395Phosphoglycerate kinaseAdd BLAST395

Proteomic databases

PRIDEiQ2G6W8

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi279238.Saro_1965

Structurei

3D structure databases

ProteinModelPortaliQ2G6W8
SMRiQ2G6W8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 24Substrate bindingUniRule annotation3
Regioni60 – 63Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q2G6W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFKTLDDIG DLTGKTVLVR EDLNVPMQDG AVTDDTRLRA TIATLNELSD
60 70 80 90 100
KGAKVLVLAH FGRPKGQPSE EFSLKKLAAP LAHVLGRPVS YIDWESDKAA
110 120 130 140 150
VAALTPGAIA VLENTRFFDG EEKNDPAVIE RFASLGDIYV NDAFSAAHRA
160 170 180 190 200
HASTEGLAHV LPAYAGRAME AELKALQKAL GEPERPVAAV VGGAKVSTKL
210 220 230 240 250
DVLKHLVSKV DHLIIGGGMA NTFLAARGVN VGKSLCEHDL TGTAEEILDN
260 270 280 290 300
ADKSGCTVHL PYDVVVSKEF TANPPSLRTC NVHEVAADEM ILDVGPAAVE
310 320 330 340 350
ALADVLKTCK TLVWNGPMGA FETEPFDAAT VALARTAAAL TKEGSLVSVA
360 370 380 390
GGGDTVAALN HAGVVGDFSY ISTAGGAFLE WMEGKELPGV AALEG
Length:395
Mass (Da):41,301
Last modified:March 21, 2006 - v1
Checksum:iEDF2D1E553119BA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000248 Genomic DNA Translation: ABD26405.1
RefSeqiWP_011445614.1, NC_007794.1

Genome annotation databases

EnsemblBacteriaiABD26405; ABD26405; Saro_1965
KEGGinar:Saro_1965

Similar proteinsi

Entry informationi

Entry nameiPGK_NOVAD
AccessioniPrimary (citable) accession number: Q2G6W8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 21, 2006
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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