Q2G6S7 (Q2G6S7_NOVAD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1 2 HAMAP MF_00223
EC=3.5.4.16 HAMAP MF_00223

Alternative name(s):
GTP cyclohydrolase I 2 HAMAP MF_00223

Gene names

Name:	folE2 HAMAP MF_00223
Ordered Locus Names:	Saro_2007

Organism

Novosphingobium aromaticivorans (strain DSM 12444) [Complete proteome] [HAMAP]

Taxonomic identifier

279238 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Novosphingobium

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223 SAAS SAAS001474
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223 SAAS SAAS001474
Subunit structure	Homopolymer By similarity. HAMAP MF_00223
Sequence similarities	Belongs to the GTP cyclohydrolase I family. HAMAP MF_00223

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_00223
Ligand	GTP-binding HAMAP MF_00223 Metal-binding HAMAP MF_00223 SAAS SAAS001474 Nucleotide-binding Zinc HAMAP MF_00223 SAAS SAAS001474
Molecular function	Hydrolase HAMAP MF_00223 SAAS SAAS001474 EMBL ABD26446.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	95	1	Zinc By similarity HAMAP MF_00223
	Metal binding	98	1	Zinc By similarity HAMAP MF_00223
	Metal binding	166	1	Zinc By similarity HAMAP MF_00223

Sequences

	Sequence		Length	Mass (Da)
	Q2G6S7 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 746FE8960EA0AD77	FASTA	204	22,782
	10 20 30 40 50 60 MSSLVGPDED DDLARGKVPV PQDVQDAIRT LIRWSGDDPE REGLLDTPKR VARAWKEYCQ 70 80 90 100 110 120 GYGEDPAVHL SRQFEEVGGY DEIVLLKDIP FQSHCEHHMA PIIGKAAIAY LPRDKVVGIS 130 140 150 160 170 180 KLARVLHGFA RRLQIQERLT AEVAQCIWDN LRPHGVAVVI EAQHACMTAR GVRTPGVGMV 190 200 TSRLMGTFLD DNRSRKEVLS LMGY

References

[1]

"Complete sequence of Novosphingobium aromaticivorans DSM 12444." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N. , Fredrickson J., Balkwill D., Romine M.F., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 12444.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000248 Genomic DNA. Translation: ABD26446.1.
RefSeq	YP_497280.1. NC_007794.1.
3D structure databases
ProteinModelPortal	Q2G6S7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2G6S7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3917327.
GenomeReviews	Gene locus Saro_2007 in contig CP000248_GR.
KEGG	nar:Saro_2007.
NMPDR	fig|48935.1.peg.2273.
PATRIC	22786736. VBINovAro50627_2055.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0302.
HOGENOM	HBG370191.
OMA	VHMCMIM.
PhylomeDB	Q2G6S7.
ProtClustDB	CLSK944465.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
KO	K01495.
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. FolE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q2G6S7_NOVAD

Accession

Primary (citable) accession number: Q2G6S7

Entry history

Integrated into UniProtKB/TrEMBL:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)