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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CIP 105152 / NBRC 16084 / F199)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processQueuosine biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciNARO279238:G1G5T-2285-MONOMER
UniPathwayiUPA00392

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:Saro_2250
OrganismiNovosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CIP 105152 / NBRC 16084 / F199)
Taxonomic identifieri279238 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium
Proteomesi
  • UP000009134 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000152391 – 342S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST342

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi279238.Saro_2250

Structurei

3D structure databases

ProteinModelPortaliQ2G636
SMRiQ2G636
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2N Bacteria
COG0809 LUCA
HOGENOMiHOG000004401
KOiK07568
OMAiYSYGDGM
OrthoDBiPOG091H00ZG

Family and domain databases

HAMAPiMF_00113 QueA, 1 hit
InterProiView protein in InterPro
IPR003699 QueA
IPR036100 QueA_sf
PANTHERiPTHR30307 PTHR30307, 1 hit
PfamiView protein in Pfam
PF02547 Queuosine_synth, 1 hit
SUPFAMiSSF111337 SSF111337, 1 hit
TIGRFAMsiTIGR00113 queA, 1 hit

Sequencei

Sequence statusi: Complete.

Q2G636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVDLFDFEL PSENIALRPA RPRDSARLLG VGRDGPFRDL IVRDLPDLLN
60 70 80 90 100
PGDVLVFNDT RVIPAQLEGQ RGEARVGATL HKRIDLRRWQ AFVRNAKRLR
110 120 130 140 150
EGDVIQFGAG VTATAEMRLP DGSWTLFFPG EEPVEVLLER AGRMPLPPYI
160 170 180 190 200
AGKRPTDEQD REDYQTMFAA KDGAVAAPTA ALHFTPSLME ALAARGVATE
210 220 230 240 250
TLTLHVGAGT FLPVKADDTQ DHQMHAEWGT IDAATADRLN AARAAGKRVI
260 270 280 290 300
AVGTTSLRLL ESATGEDRVI RPFEGDTSIF ITPGYTFRAI DGLMTNFHLP
310 320 330 340
KSTLFMLVSA LMGLDRMQAA YAHAIAGGYR FYSYGDSSLL LP
Length:342
Mass (Da):37,518
Last modified:March 21, 2006 - v1
Checksum:i49473309AE7DDA6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000248 Genomic DNA Translation: ABD26687.1
RefSeqiWP_011445893.1, NC_007794.1

Genome annotation databases

EnsemblBacteriaiABD26687; ABD26687; Saro_2250
KEGGinar:Saro_2250

Similar proteinsi

Entry informationi

Entry nameiQUEA_NOVAD
AccessioniPrimary (citable) accession number: Q2G636
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: April 25, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health