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Q2G5F5

- PNP_NOVAD

UniProt

Q2G5F5 - PNP_NOVAD

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Novosphingobium aromaticivorans (strain DSM 12444 / F199)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi486 – 4861MagnesiumUniRule annotation
Metal bindingi492 – 4921MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciNARO279238:GHBU-2525-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Saro_2482
OrganismiNovosphingobium aromaticivorans (strain DSM 12444 / F199)
Taxonomic identifieri279238 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium
ProteomesiUP000009134: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 772772Polyribonucleotide nucleotidyltransferasePRO_0000329742Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279238.Saro_2482.

Structurei

3D structure databases

ProteinModelPortaliQ2G5F5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini553 – 61260KHUniRule annotationAdd
BLAST
Domaini622 – 69069S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2G5F5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFDVKTVSLE WGGKTLTLET GRIARQADGA VLATYGETVV LCAVTAAKSV
60 70 80 90 100
KEGQDFFPLT VHYQEKYSAA GRIPGGFFKR ERGATEKETL VSRLIDRPVR
110 120 130 140 150
PLFPEGFYNE INVIAQVLSY DGETEPDIVA MIAASAALTI SGVPFMGPIA
160 170 180 190 200
AARVGFIEGE YVLNPKQDVA LADGRLDLVV AATDTAVMMV ESEAKELSED
210 220 230 240 250
EMLGAVLFAH DEIKKVIGAI IQLAEKAAKD PWDIDLSDNT ADIKKKLKDL
260 270 280 290 300
VGKDVAAAYK LTDKSARSNA LNEARAKAKA AFAEEGAQTQ MVAMKTMKKV
310 320 330 340 350
EADIVRGAIL KDGQRIDGRT TTQVRPIEAI VGFLPRTHGS SLFTRGETQA
360 370 380 390 400
ICTTTLGTKD AEQMIDGLEG LRYENFMLHY NFPPYSVGEV GRFGAPGRRE
410 420 430 440 450
VGHGKLAWRA LHPVLPTKEE FPYTIRILSD ITESNGSSSM ATVCGGCLSM
460 470 480 490 500
MDAGVPVKRP VSGIAMGLIL EGDKFAVLSD ILGDEDHLGD MDFKVAGTSE
510 520 530 540 550
GITTMQMDIK VAGITREIFE VALRQASEGR AHILGEMTKA LGEARTELSA
560 570 580 590 600
HAPRIETLQI DKSKIRDVIG TGGKVIREIV ATTGAKVDID DEGLIKISSS
610 620 630 640 650
DLTQIEAAKN WILGIVEEAE VGKIYKGKVV NIVDFGAFVN FMGGKDGLVH
660 670 680 690 700
VSEMKNERVE KPTDVVKEGQ DVYVKVLEID QRGKVRLSMR VVDQETGAEL
710 720 730 740 750
EDTRPPREPR EPRGDRGDRG DRGDRRGPRG DRGPRREGGD RGPRREGGDR
760 770
PRRDRDDGPA PDHMPAFLKS DD
Length:772
Mass (Da):83,936
Last modified:March 21, 2006 - v1
Checksum:iFE62B30439EB8A7A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000248 Genomic DNA. Translation: ABD26918.1.
RefSeqiWP_011446124.1. NC_007794.1.
YP_497752.1. NC_007794.1.

Genome annotation databases

EnsemblBacteriaiABD26918; ABD26918; Saro_2482.
GeneIDi3916802.
KEGGinar:Saro_2482.
PATRICi22787716. VBINovAro50627_2538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000248 Genomic DNA. Translation: ABD26918.1 .
RefSeqi WP_011446124.1. NC_007794.1.
YP_497752.1. NC_007794.1.

3D structure databases

ProteinModelPortali Q2G5F5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279238.Saro_2482.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD26918 ; ABD26918 ; Saro_2482 .
GeneIDi 3916802.
KEGGi nar:Saro_2482.
PATRICi 22787716. VBINovAro50627_2538.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci NARO279238:GHBU-2525-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12444 / F199.

Entry informationi

Entry nameiPNP_NOVAD
AccessioniPrimary (citable) accession number: Q2G5F5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 21, 2006
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3