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Q2G3F4 (UPPP_NOVAD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Saro_3184
OrganismNovosphingobium aromaticivorans (strain DSM 12444) [Complete proteome] [HAMAP]
Taxonomic identifier279238 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000250248

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane108 – 12821Helical; Potential
Transmembrane184 – 20421Helical; Potential
Transmembrane217 – 23721Helical; Potential
Transmembrane249 – 26921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q2G3F4 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: D94FFE311CD3D599

FASTA27028,715
        10         20         30         40         50         60 
MDTIVTAILL GIVEGLTEFL PVSSTGHLIL ATELFGYDAH QWAMFNVVIQ LGAILAVVVQ 

        70         80         90        100        110        120 
YWRTFWAVGM GLLRLEPISL RFLRNLLAAF IPSAILGLAL KKYIDVLLGS PSVVCWALIA 

       130        140        150        160        170        180 
GGIAILVIEK HAKQGEPSGI GQLPLRQAIG VGLAQCLAMV PGVSRSGATI MGALAMGIER 

       190        200        210        220        230        240 
RTAAEFSFFL AIPTMLGATT LELLDNRDAL LGGTMGVGWS EIGVGFAVSF VVALAVIRLF 

       250        260        270 
VAYVSRAGFK PFAWYRIAAG AVALGWLAMR 

« Hide

References

[1]"Complete sequence of Novosphingobium aromaticivorans DSM 12444."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N. expand/collapse author list , Fredrickson J., Balkwill D., Romine M.F., Richardson P.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 12444.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000248 Genomic DNA. Translation: ABD27619.1.
RefSeqYP_498453.1. NC_007794.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING279238.Saro_3184.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD27619; ABD27619; Saro_3184.
GeneID3917442.
KEGGnar:Saro_3184.
PATRIC22789228. VBINovAro50627_3266.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBCLSK2776066.

Enzyme and pathway databases

BioCycNARO279238:GHBU-3256-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_NOVAD
AccessionPrimary (citable) accession number: Q2G3F4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 21, 2006
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families