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Q2G3C3

- SYL_NOVAD

UniProt

Q2G3C3 - SYL_NOVAD

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Novosphingobium aromaticivorans (strain DSM 12444 / F199)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei628 – 6281ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNARO279238:GHBU-3287-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Saro_3215
OrganismiNovosphingobium aromaticivorans (strain DSM 12444 / F199)
Taxonomic identifieri279238 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium
ProteomesiUP000009134: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 848848Leucine--tRNA ligasePRO_0000334784Add
BLAST

Proteomic databases

PRIDEiQ2G3C3.

Interactioni

Protein-protein interaction databases

STRINGi279238.Saro_3215.

Structurei

3D structure databases

ProteinModelPortaliQ2G3C3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 6111"HIGH" regionAdd
BLAST
Motifi625 – 6295"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2G3C3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTENTPGTSA PERFDPATAD TRWQRVWDEK QSFRADDSST KPRSYVLEMF
60 70 80 90 100
PYPSGRIHIG HVRNYTMGDV LARYKRMRGF EVLHPMGWDA FGMPAENAAM
110 120 130 140 150
EKGVHPGGWT RDNIANMKAQ LKRLGFALDW SREIATCEPE YYGQEQALFL
160 170 180 190 200
DLYAAGLVYR KESTVNWDPV DMTVLANEQV IDGRGWRSGA LVEKRKLNQW
210 220 230 240 250
FLKITDFADE LLEGLSTLDK WPEKVRVMQE NWIGKSQGLQ FRFDLSNGET
260 270 280 290 300
VEVYTTRPDT IFGASFVAVA PDHPIAQGVA AINCEAANFI ALCKKGGTTA
310 320 330 340 350
AELETAEKLG FDTGIGARHP LTGKYLPVYI ANFVLMEYGT GAIMAVPGHD
360 370 380 390 400
QRDFDFATKY ALPILRVVAA DAADADKPFA GEAEAGDGVL VNSGFLDGMN
410 420 430 440 450
VADAKAAVIV RAESEGWGEG KTVWRLRDWG VSRQRYWGTP IPFIHCEVCG
460 470 480 490 500
VVPVPKKHLP VTLPEDVSFD VPGNPLDRHP TWKHVDCPQC GHPARRETDT
510 520 530 540 550
LDTFVDSSWY FLRFASQPED RPFDPEEIKR WLPVEQYIGG IEHAILHLLY
560 570 580 590 600
ARFWTRALAR IGKVEVTEPF GSLFTQGMVT HETYERRNPE NGQPIFFSPG
610 620 630 640 650
EVERTGEGAT LKVDGAPVEI GRVIKMSKSK KNVVDPDEIV AKYGADAIRW
660 670 680 690 700
FMLSDSPPER DLPWSEAGIE GCARFVQRLW RLFGQYDAAA TGEDKALDRK
710 720 730 740 750
AHQTVHAVAS DIEALGFNKA VARIYELTGA VEKAAPSASR SDAIRKLLLL
760 770 780 790 800
VAPMMPHLAE EAYARFGSSL IADAAWPEVD PALLVDDEVI VAVQVKGKLR
810 820 830 840
DTLTVAKGTP KEDLERLALA SEKVQRALEG AEVKKVIVVP DRLVNLVA
Length:848
Mass (Da):94,260
Last modified:March 21, 2006 - v1
Checksum:iD2C85B84C8D6C88B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000248 Genomic DNA. Translation: ABD27650.1.
RefSeqiWP_011446852.1. NC_007794.1.
YP_498484.1. NC_007794.1.

Genome annotation databases

EnsemblBacteriaiABD27650; ABD27650; Saro_3215.
GeneIDi3917473.
KEGGinar:Saro_3215.
PATRICi22789292. VBINovAro50627_3298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000248 Genomic DNA. Translation: ABD27650.1 .
RefSeqi WP_011446852.1. NC_007794.1.
YP_498484.1. NC_007794.1.

3D structure databases

ProteinModelPortali Q2G3C3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279238.Saro_3215.

Proteomic databases

PRIDEi Q2G3C3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD27650 ; ABD27650 ; Saro_3215 .
GeneIDi 3917473.
KEGGi nar:Saro_3215.
PATRICi 22789292. VBINovAro50627_3298.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci NARO279238:GHBU-3287-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12444 / F199.

Entry informationi

Entry nameiSYL_NOVAD
AccessioniPrimary (citable) accession number: Q2G3C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 21, 2006
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3