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Q2G3C3

- SYL_NOVAD

UniProt

Q2G3C3 - SYL_NOVAD

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Novosphingobium aromaticivorans (strain DSM 12444 / F199)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei628 – 6281ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNARO279238:GHBU-3287-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Saro_3215
    OrganismiNovosphingobium aromaticivorans (strain DSM 12444 / F199)
    Taxonomic identifieri279238 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium
    ProteomesiUP000009134: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 848848Leucine--tRNA ligasePRO_0000334784Add
    BLAST

    Proteomic databases

    PRIDEiQ2G3C3.

    Interactioni

    Protein-protein interaction databases

    STRINGi279238.Saro_3215.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2G3C3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi51 – 6111"HIGH" regionAdd
    BLAST
    Motifi625 – 6295"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2G3C3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTENTPGTSA PERFDPATAD TRWQRVWDEK QSFRADDSST KPRSYVLEMF    50
    PYPSGRIHIG HVRNYTMGDV LARYKRMRGF EVLHPMGWDA FGMPAENAAM 100
    EKGVHPGGWT RDNIANMKAQ LKRLGFALDW SREIATCEPE YYGQEQALFL 150
    DLYAAGLVYR KESTVNWDPV DMTVLANEQV IDGRGWRSGA LVEKRKLNQW 200
    FLKITDFADE LLEGLSTLDK WPEKVRVMQE NWIGKSQGLQ FRFDLSNGET 250
    VEVYTTRPDT IFGASFVAVA PDHPIAQGVA AINCEAANFI ALCKKGGTTA 300
    AELETAEKLG FDTGIGARHP LTGKYLPVYI ANFVLMEYGT GAIMAVPGHD 350
    QRDFDFATKY ALPILRVVAA DAADADKPFA GEAEAGDGVL VNSGFLDGMN 400
    VADAKAAVIV RAESEGWGEG KTVWRLRDWG VSRQRYWGTP IPFIHCEVCG 450
    VVPVPKKHLP VTLPEDVSFD VPGNPLDRHP TWKHVDCPQC GHPARRETDT 500
    LDTFVDSSWY FLRFASQPED RPFDPEEIKR WLPVEQYIGG IEHAILHLLY 550
    ARFWTRALAR IGKVEVTEPF GSLFTQGMVT HETYERRNPE NGQPIFFSPG 600
    EVERTGEGAT LKVDGAPVEI GRVIKMSKSK KNVVDPDEIV AKYGADAIRW 650
    FMLSDSPPER DLPWSEAGIE GCARFVQRLW RLFGQYDAAA TGEDKALDRK 700
    AHQTVHAVAS DIEALGFNKA VARIYELTGA VEKAAPSASR SDAIRKLLLL 750
    VAPMMPHLAE EAYARFGSSL IADAAWPEVD PALLVDDEVI VAVQVKGKLR 800
    DTLTVAKGTP KEDLERLALA SEKVQRALEG AEVKKVIVVP DRLVNLVA 848
    Length:848
    Mass (Da):94,260
    Last modified:March 21, 2006 - v1
    Checksum:iD2C85B84C8D6C88B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000248 Genomic DNA. Translation: ABD27650.1.
    RefSeqiWP_011446852.1. NC_007794.1.
    YP_498484.1. NC_007794.1.

    Genome annotation databases

    EnsemblBacteriaiABD27650; ABD27650; Saro_3215.
    GeneIDi3917473.
    KEGGinar:Saro_3215.
    PATRICi22789292. VBINovAro50627_3298.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000248 Genomic DNA. Translation: ABD27650.1 .
    RefSeqi WP_011446852.1. NC_007794.1.
    YP_498484.1. NC_007794.1.

    3D structure databases

    ProteinModelPortali Q2G3C3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 279238.Saro_3215.

    Proteomic databases

    PRIDEi Q2G3C3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD27650 ; ABD27650 ; Saro_3215 .
    GeneIDi 3917473.
    KEGGi nar:Saro_3215.
    PATRICi 22789292. VBINovAro50627_3298.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci NARO279238:GHBU-3287-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 12444 / F199.

    Entry informationi

    Entry nameiSYL_NOVAD
    AccessioniPrimary (citable) accession number: Q2G3C3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3