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Reviewed, UniProtKB/Swiss-Prot Q2G2V3 (MENE_STAA8)

Last modified June 16, 2009. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    2-succinylbenzoate--CoA ligase
    EC=6.2.1.26
Alternative name(s):
    OSB-CoA synthetase
    o-succinylbenzoyl-CoA synthetase
Gene names
Name: menE
Ordered Locus Names: SAOUHSC_01916
OrganismStaphylococcus aureus (strain NCTC 8325) [Complete proteome] [HAMAP]
Taxonomic identifier93061 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

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Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA). HAMAP MF_00731

Catalytic activity

ATP + 2-succinylbenzoate + CoA = AMP + diphosphate + 2-succinylbenzoyl-CoA. HAMAP MF_00731

Pathway

Cofactor biosynthesis; menaquinone biosynthesis; menaquinone from chorismate: step 5/8. HAMAP MF_00731

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. MenE type 1 subfamily.

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Ontologies

Keywords
   Biological processMenaquinone biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmenaquinone biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

o-succinylbenzoate-CoA ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4924922-succinylbenzoate--CoA ligase HAMAP MF_00731
PRO_1000045967

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Sequences

Sequence LengthMass (Da)Tools
Q2G2V3-1 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 36D409105A4F7930

FASTA49255,415
        10         20         30         40         50         60 
MDFWLYKQAQ QNGHHIAITD GQESYTYQNL YCEASLLAKR LKAYQQSRVG LYIDNSIQSI 

        70         80         90        100        110        120 
ILIHACWLAN IEIAMINTRL TPNEMTNQMK SIDVQLIFCT LPLELRGFQI VSLDDIEFAG 

       130        140        150        160        170        180 
RDITTNSLLD NTMGIQYETS NETVVPKESP SNILNTSFNL DDIASIMFTS GTTGPQKAVP 

       190        200        210        220        230        240 
QTFRNHYASA IGCKESLGFD RDTNWLSVLP IYHISGLSVL LRAVIEGFTV RIVDKFNAEQ 

       250        260        270        280        290        300 
ILTMIKNERI THISLVPQTL NWLMQQGLHE PYNLQKILLG GAKLSATMIE TALQYNLPIY 

       310        320        330        340        350        360 
NSFGMTETCS QFLTATPEML HARPDTVGMP SANVDVKIKN PNKEGHGELM IKGANVMNVY 

       370        380        390        400        410        420 
LYPTDLTGTF ENGYFNTGDI AEIDHEGYVM IYDRRKDLII SGGENIYPYQ IETVAKQFPG 

       430        440        450        460        470        480 
ISDAVCVGHP DDTWGQVPKL YFVSESDISK AQLIAYLSQH LAKYKVPKHF EKVDTLPYTS 

       490 
TGKLQRNKLY RG

« Hide

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References

[1]"The Staphylococcus aureus NCTC8325 genome."
Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000253 Genomic DNA. Translation: ABD30979.1.
RefSeqYP_500417.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3921058.
GenomeReviewsGene locus SAOUHSC_01916 in contig CP000253_GR.
KEGGsao:SAOUHSC_01916.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ2G2V3.
OMAQ2G2V3. DSPSNIL.

Enzyme and pathway databases

BioCycSAUR93061:SAOUHSC_01916-MON.

Family and domain databases

HAMAPMF_00731.
[Tree]
InterProIPR000873. AMP-dep_Synth/Lig.
IPR010192. MenE.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
TIGRFAMsTIGR01923. menE. 1 hit.
PROSITEPS00455. AMP_BINDING. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameMENE_STAA8
AccessionPrimary (citable) accession number: Q2G2V3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents