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Protein

Galactose-6-phosphate isomerase subunit LacA

Gene

lacA

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-galactose 6-phosphate = D-tagatose 6-phosphate.UniRule annotation

Pathwayi: D-galactose 6-phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Galactose-6-phosphate isomerase subunit LacB (lacB), Galactose-6-phosphate isomerase subunit LacA (lacA)
This subpathway is part of the pathway D-galactose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate, the pathway D-galactose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lactose metabolism

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-2390-MONOMER.
UniPathwayiUPA00702; UER00714.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-6-phosphate isomerase subunit LacAUniRule annotation (EC:5.3.1.26UniRule annotation)
Gene namesi
Name:lacAUniRule annotation
Ordered Locus Names:SAOUHSC_02455
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Galactose-6-phosphate isomerase subunit LacAPRO_0000247669Add
BLAST

Interactioni

Subunit structurei

Heteromultimeric protein consisting of LacA and LacB.UniRule annotation

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02455.

Structurei

3D structure databases

ProteinModelPortaliQ2G2R4.
SMRiQ2G2R4. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LacAB/RpiB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105RSI. Bacteria.
COG0698. LUCA.
HOGENOMiHOG000226301.
KOiK01819.
OMAiLKVTHEV.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
HAMAPiMF_01555. LacA. 1 hit.
InterProiIPR004783. LacA.
IPR003500. RpiB_LacA_LacB.
[Graphical view]
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiPF02502. LacAB_rpiB. 1 hit.
[Graphical view]
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01118. lacA. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2G2R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIIIGSDEA GKRLKEVIKS YLLDNKYDVV DVTEGQEVDF VDATLAVAKD
60 70 80 90 100
VQSQEGNLGI VIDAFGAGSF MVATKIKGMI AAEVSDERSG YMTRGHNNSR
110 120 130 140
MITMGSEIVG DTLAKNVVKG FVEGKYDGGR HQIRVDMLNK MC
Length:142
Mass (Da):15,395
Last modified:March 21, 2006 - v1
Checksum:iA52C4A7DBF30BE19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD31475.1.
M32103 Genomic DNA. Translation: AAA67855.1.
PIRiA38158.
RefSeqiYP_500922.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD31475; ABD31475; SAOUHSC_02455.
GeneIDi3919018.
KEGGisao:SAOUHSC_02455.
PATRICi19582216. VBIStaAur99865_2214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD31475.1.
M32103 Genomic DNA. Translation: AAA67855.1.
PIRiA38158.
RefSeqiYP_500922.1. NC_007795.1.

3D structure databases

ProteinModelPortaliQ2G2R4.
SMRiQ2G2R4. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02455.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD31475; ABD31475; SAOUHSC_02455.
GeneIDi3919018.
KEGGisao:SAOUHSC_02455.
PATRICi19582216. VBIStaAur99865_2214.

Phylogenomic databases

eggNOGiENOG4105RSI. Bacteria.
COG0698. LUCA.
HOGENOMiHOG000226301.
KOiK01819.
OMAiLKVTHEV.

Enzyme and pathway databases

UniPathwayiUPA00702; UER00714.
BioCyciSAUR93061:GIWJ-2390-MONOMER.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
HAMAPiMF_01555. LacA. 1 hit.
InterProiIPR004783. LacA.
IPR003500. RpiB_LacA_LacB.
[Graphical view]
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiPF02502. LacAB_rpiB. 1 hit.
[Graphical view]
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01118. lacA. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLACA_STAA8
AccessioniPrimary (citable) accession number: Q2G2R4
Secondary accession number(s): P26594
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 21, 2006
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.