Q2G2R4 (LACA_STAA8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactose-6-phosphate isomerase subunit lacA
EC=5.3.1.26

Gene names

Name:	lacA
Ordered Locus Names:	SAOUHSC_02455

Organism

Staphylococcus aureus (strain NCTC 8325)

Taxonomic identifier

93061 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-galactose 6-phosphate = D-tagatose 6-phosphate. HAMAP MF_01555
Pathway	Carbohydrate metabolism; D-galactose 6-phosphate degradation; D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1. HAMAP MF_01555
Subunit structure	Heteromultimeric protein consisting of lacA and lacB By similarity.
Sequence similarities	Belongs to the lacAB/rpiB family.

Ontologies

Keywords
Biological process	Lactose metabolism
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lactose catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	galactose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Galactose-6-phosphate isomerase subunit lacA HAMAP MF_01555		PRO_0000247669

Sequences

	Sequence		Length	Mass (Da)
	Q2G2R4 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: A52C4A7DBF30BE19	FASTA	142	15,395
	10 20 30 40 50 60 MAIIIGSDEA GKRLKEVIKS YLLDNKYDVV DVTEGQEVDF VDATLAVAKD VQSQEGNLGI 70 80 90 100 110 120 VIDAFGAGSF MVATKIKGMI AAEVSDERSG YMTRGHNNSR MITMGSEIVG DTLAKNVVKG 130 140 FVEGKYDGGR HQIRVDMLNK MC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 8325.
[2]	"Repression and catabolite repression of the lactose operon of Staphylococcus aureus." Oskouian B., Stewart G.C. J. Bacteriol. 172:3804-3812(1990) [PubMed: 2163387] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-63.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000253 Genomic DNA. Translation: ABD31475.1. M32103 Genomic DNA. Translation: AAA67855.1.
PIR	A38158.
RefSeq	YP_500922.1. NC_007795.1.
3D structure databases
ProteinModelPortal	Q2G2R4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2G2R4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000028712; EBSTAP00000027663; EBSTAG00000028711.
GeneID	3919018.
GenomeReviews	Gene locus SAOUHSC_02455 in contig CP000253_GR.
KEGG	sao:SAOUHSC_02455.
PATRIC	19582216. VBIStaAur99865_2214.
Phylogenomic databases
eggNOG	COG0698.
GeneTree	EBGT00050000024804.
HOGENOM	HBG636953.
OMA	GIMIDAY.
ProtClustDB	PRK08621.
Enzyme and pathway databases
BioCyc	SAUR93061:SAOUHSC_02455-MONOMER.
Family and domain databases
HAMAP	MF_01555. LacA. [Tree]
InterPro	IPR004783. Gal-6-P_isomerase_su_LacA. IPR003500. Rib/Gal_isomrase. [Graphical view]
Gene3D	G3DSA:3.40.1400.10. Rib/Gal_isomrase. 1 hit.
KO	K01819.
Pfam	PF02502. LacAB_rpiB. 1 hit. [Graphical view]
PIRSF	PIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAM	SSF89623. Rib/Gal_isomrase. 1 hit.
TIGRFAMs	TIGR01118. LacA. 1 hit. TIGR00689. RpiB_lacA_lacB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LACA_STAA8

Accession

Primary (citable) accession number: Q2G2R4
Secondary accession number(s): P26594

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program