Q2G2R0 (LACB_STAA8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactose-6-phosphate isomerase subunit lacB
EC=5.3.1.26

Gene names

Name:	lacB
Ordered Locus Names:	SAOUHSC_02454

Organism

Staphylococcus aureus (strain NCTC 8325)

Taxonomic identifier

93061 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-galactose 6-phosphate = D-tagatose 6-phosphate. HAMAP MF_01556
Pathway	Carbohydrate metabolism; D-galactose 6-phosphate degradation; D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1. HAMAP MF_01556
Subunit structure	Heteromultimeric protein consisting of lacA and lacB By similarity.
Sequence similarities	Belongs to the lacAB/rpiB family.

Ontologies

Keywords
Biological process	Lactose metabolism
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lactose catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	galactose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Galactose-6-phosphate isomerase subunit lacB HAMAP MF_01556		PRO_0000247670

Sequences

	Sequence		Length	Mass (Da)
	Q2G2R0 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 10617F0F28536A13	FASTA	171	18,951
	10 20 30 40 50 60 MKIALGCDHI VTDTKMRVSE FLKSKGHEVI DVGTYDFTRT HYPIFGKKVG EQVVSGNADL 70 80 90 100 110 120 GVCICGTGVG INNAVNKVPG VRSALVRDMT SALYAKEELN ANVIGFGGRI IGELLMCDII 130 140 150 160 170 DAFINAEYKP TEENKKLIAK IKHLETSNAD QADPHFFDEF LEKWDRGEYH D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 8325.
[2]	"The nucleotide sequence of the lacC and lacD genes of Staphylococcus aureus." Rosey E.L., Stewart G.C. Nucleic Acids Res. 17:3980-3980(1989) [PubMed: 2543958] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 159-171.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000253 Genomic DNA. Translation: ABD31474.1. X14827 Genomic DNA. No translation available.
PIR	B38158.
RefSeq	YP_500921.1. NC_007795.1.
3D structure databases
ProteinModelPortal	Q2G2R0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2G2R0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000029399; EBSTAP00000028350; EBSTAG00000029397.
GeneID	3919017.
GenomeReviews	Gene locus SAOUHSC_02454 in contig CP000253_GR.
KEGG	sao:SAOUHSC_02454.
PATRIC	19582214. VBIStaAur99865_2213.
Phylogenomic databases
eggNOG	COG0698.
GeneTree	EBGT00050000024803.
HOGENOM	HBG636953.
OMA	ETHHANQ.
ProtClustDB	PRK08622.
Enzyme and pathway databases
BioCyc	SAUR93061:SAOUHSC_02454-MONOMER.
Family and domain databases
HAMAP	MF_01556. LacB. [Tree]
InterPro	IPR004784. LacB. IPR003500. Rib/Gal_isomrase. [Graphical view]
Gene3D	G3DSA:3.40.1400.10. Rib/Gal_isomrase. 1 hit.
KO	K01819.
Pfam	PF02502. LacAB_rpiB. 1 hit. [Graphical view]
PIRSF	PIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAM	SSF89623. Rib/Gal_isomrase. 1 hit.
TIGRFAMs	TIGR01119. LacB. 1 hit. TIGR00689. RpiB_lacA_lacB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LACB_STAA8

Accession

Primary (citable) accession number: Q2G2R0
Secondary accession number(s): P26592, P68796

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program