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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-1716-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:SAOUHSC_01845
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003005441 – 555Formate--tetrahydrofolate ligaseAdd BLAST555

Proteomic databases

PRIDEiQ2G296

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01845

Structurei

3D structure databases

ProteinModelPortaliQ2G296
SMRiQ2G296
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2G296-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHLSDLDIA NQSTLQPIKD IAASVGISED ALEPYGHYKA KIDINKITPR
60 70 80 90 100
ENKGKVVLVT AMSPTPAGEG KSTVTVGLAD AFHELNKNVM VALREPALGP
110 120 130 140 150
TFGIKGGATG GGYAQVLPME DINLHFNGDF HAITTANNAL SAFIDNHIHQ
160 170 180 190 200
GNELGIDQRR IEWKRVLDMN DRALRHVNVG LGGPTNGVPR EDGFNITVAS
210 220 230 240 250
EIMAILCLSR SIKDLKDKIS RITIGYTRDR KPVTVADLKV EGALAMILKD
260 270 280 290 300
AIKPNLVQSI EGTPALVHGG PFANIAHGCN SILATETARD LADIVVTEAG
310 320 330 340 350
FGSDLGAEKF MDIKAREAGF DPAAVVVVAT IRALKMHGGV AKDNLKEENV
360 370 380 390 400
EAVKAGIVNL ERHVNNIKKF GVEPVVAINA FIHDTDAEVE YVKSWAKENN
410 420 430 440 450
VRIALTEVWE KGGKGGVDLA NEVLEVIDQP NSFKPLYELE LPLEQKIEKI
460 470 480 490 500
VTEIYGGSKV TFSSKAQKQL KQFKENGWDN YPVCMAKTQY SFSDDQTLLG
510 520 530 540 550
APSGFEITIR ELEAKTGAGF IVALTGAIMT MPGLPKKPAA LNMDVTDDGH

AIGLF
Length:555
Mass (Da):59,856
Last modified:March 21, 2006 - v1
Checksum:i8314C426AEFDF11A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA Translation: ABD30912.1
RefSeqiWP_000149403.1, NC_007795.1
YP_500350.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD30912; ABD30912; SAOUHSC_01845
GeneIDi3920524
KEGGisao:SAOUHSC_01845
PATRICifig|93061.5.peg.1681

Similar proteinsi

Entry informationi

Entry nameiFTHS_STAA8
AccessioniPrimary (citable) accession number: Q2G296
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 21, 2006
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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