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Protein

Superoxide dismutase [Mn/Fe] 2

Gene

sodM

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in maintaining cell viability during the late-exponential and stationary phases of growth since it becomes a major source of activity under oxidative stress. Has a role in resisting external superoxide stress. Involved in acid tolerance and the acid-adaptive response. Mediates the derepression of perR regulon in the response to HOCl stress at low level of SOD activity (By similarity).By similarity2 Publications

Miscellaneous

According to PubMed:11344148 the levels of SodM activity and sodM expression are growth-phase dependent, occurring most during the late-exponential and stationary phases. This response is also dependent on the level of aeration with highest activity occurring under high aeration. SodM expression under low-aeration growth conditions is most abundant during the late-exponential phase while under high-aeration growth conditions is highest during the stationary phase.
Transcribed from a single sigmaA-type promoter (PM). Transcriptional data show an indirect repression of PM promoter by sigmaB which can also be involved in the post-transcriptional regulation of SodM homodimer activity.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarity, Fe2+By similarityNote: Binds 1 Mn2+ or Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Manganese or ironBy similarity1
Metal bindingi81Manganese or ironBy similarity1
Metal bindingi161Manganese or ironBy similarity1
Metal bindingi165Manganese or ironBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processStress response
LigandIron, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-87-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn/Fe] 2 (EC:1.15.1.1)
Gene namesi
Name:sodM
Ordered Locus Names:SAOUHSC_00093
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002939651 – 199Superoxide dismutase [Mn/Fe] 2Add BLAST199

Expressioni

Inductioni

Transcriptionally induced by externally generated superoxide stress in a manganese-dependent way. The presence of manganese increases SodA homodimer activity and simultaneously decreases SodM homodimer activity. This occurs primarily due to post-transcriptional effects, since the expression of the gene is independent of manganese availability in the absence of superoxide generating compounds.

Interactioni

Subunit structurei

Homodimer. Can also form a heterodimer with SodA.1 Publication

Protein-protein interaction databases

STRINGi93061.SAOUHSC_00093

Structurei

3D structure databases

ProteinModelPortaliQ2G261
SMRiQ2G261
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CK4 Bacteria
COG0605 LUCA
HOGENOMiHOG000013583
KOiK04564
OMAiDHHGNVG

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Q2G261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFKLPNLPY AYDALEPYID QRTMEFHHDK HHNTYVTKLN ATVEGTELEH
60 70 80 90 100
QSLADMIANL DKVPEAMRMS VRNNGGGHFN HSLFWEILSP NSEEKGGVID
110 120 130 140 150
DIKAQWGTLD EFKNEFANKA TTLFGSGWTW LVVNDGKLEI VTTPNQDNPL
160 170 180 190
TEGKTPILLF DVWEHAYYLK YQNKRPDYMT AFWNIVNWKK VDELYQAAK
Length:199
Mass (Da):23,041
Last modified:March 21, 2006 - v1
Checksum:i388566FB9943C635
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61D → G in AAG44813 (PubMed:11344148).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273269 Genomic DNA Translation: AAG44813.2
CP000253 Genomic DNA Translation: ABD29276.1
Z49245 Genomic DNA Translation: CAA89212.1
PIRiS54793
RefSeqiWP_000874681.1, NC_007795.1
YP_498694.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD29276; ABD29276; SAOUHSC_00093
GeneIDi3919804
KEGGisao:SAOUHSC_00093
PATRICifig|93061.5.peg.83

Similar proteinsi

Entry informationi

Entry nameiSODM2_STAA8
AccessioniPrimary (citable) accession number: Q2G261
Secondary accession number(s): Q59806, Q9EZZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health