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Q2G261

- SODM2_STAA8

UniProt

Q2G261 - SODM2_STAA8

Protein

Superoxide dismutase [Mn/Fe] 2

Gene

sodM

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in maintaining cell viability during the late-exponential and stationary phases of growth since it becomes a major source of activity under oxidative stress. Has a role in resisting external superoxide stress. Involved in acid tolerance and the acid-adaptive response. Mediates the derepression of perR regulon in the response to HOCl stress at low level of SOD activity By similarity.By similarity

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 manganese or iron ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi27 – 271Manganese or ironBy similarity
    Metal bindingi81 – 811Manganese or ironBy similarity
    Metal bindingi161 – 1611Manganese or ironBy similarity
    Metal bindingi165 – 1651Manganese or ironBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. superoxide dismutase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    Iron, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSAUR93061:GIWJ-88-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Mn/Fe] 2 (EC:1.15.1.1)
    Gene namesi
    Name:sodM
    Ordered Locus Names:SAOUHSC_00093
    OrganismiStaphylococcus aureus (strain NCTC 8325)
    Taxonomic identifieri93061 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000008816: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 199199Superoxide dismutase [Mn/Fe] 2PRO_0000293965Add
    BLAST

    Expressioni

    Inductioni

    Transcriptionally induced by externally generated superoxide stress in a manganese-dependent way. The presence of manganese increases SodA homodimer activity and simultaneously decreases SodM homodimer activity. This occurs primarily due to post-transcriptional effects, since the expression of the gene is independent of manganese availability in the absence of superoxide generating compounds.

    Interactioni

    Subunit structurei

    Homodimer. Can also form a heterodimer with SodA.1 Publication

    Protein-protein interaction databases

    STRINGi93061.SAOUHSC_00093.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2G261.
    SMRiQ2G261. Positions 3-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0605.
    HOGENOMiHOG000013583.
    KOiK04564.
    OMAiDSLINWD.
    OrthoDBiEOG63NMNT.

    Family and domain databases

    InterProiIPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view]
    PANTHERiPTHR11404. PTHR11404. 1 hit.
    PfamiPF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000349. SODismutase. 1 hit.
    PRINTSiPR01703. MNSODISMTASE.
    SUPFAMiSSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEiPS00088. SOD_MN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2G261-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFKLPNLPY AYDALEPYID QRTMEFHHDK HHNTYVTKLN ATVEGTELEH    50
    QSLADMIANL DKVPEAMRMS VRNNGGGHFN HSLFWEILSP NSEEKGGVID 100
    DIKAQWGTLD EFKNEFANKA TTLFGSGWTW LVVNDGKLEI VTTPNQDNPL 150
    TEGKTPILLF DVWEHAYYLK YQNKRPDYMT AFWNIVNWKK VDELYQAAK 199
    Length:199
    Mass (Da):23,041
    Last modified:March 21, 2006 - v1
    Checksum:i388566FB9943C635
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti61 – 611D → G in AAG44813. (PubMed:11344148)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF273269 Genomic DNA. Translation: AAG44813.2.
    CP000253 Genomic DNA. Translation: ABD29276.1.
    Z49245 Genomic DNA. Translation: CAA89212.1.
    PIRiS54793.
    RefSeqiYP_498694.1. NC_007795.1.

    Genome annotation databases

    EnsemblBacteriaiABD29276; ABD29276; SAOUHSC_00093.
    GeneIDi3919804.
    KEGGisao:SAOUHSC_00093.
    PATRICi19577814. VBIStaAur99865_0083.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF273269 Genomic DNA. Translation: AAG44813.2 .
    CP000253 Genomic DNA. Translation: ABD29276.1 .
    Z49245 Genomic DNA. Translation: CAA89212.1 .
    PIRi S54793.
    RefSeqi YP_498694.1. NC_007795.1.

    3D structure databases

    ProteinModelPortali Q2G261.
    SMRi Q2G261. Positions 3-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93061.SAOUHSC_00093.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD29276 ; ABD29276 ; SAOUHSC_00093 .
    GeneIDi 3919804.
    KEGGi sao:SAOUHSC_00093.
    PATRICi 19577814. VBIStaAur99865_0083.

    Phylogenomic databases

    eggNOGi COG0605.
    HOGENOMi HOG000013583.
    KOi K04564.
    OMAi DSLINWD.
    OrthoDBi EOG63NMNT.

    Enzyme and pathway databases

    BioCyci SAUR93061:GIWJ-88-MONOMER.

    Family and domain databases

    InterProi IPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view ]
    PANTHERi PTHR11404. PTHR11404. 1 hit.
    Pfami PF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000349. SODismutase. 1 hit.
    PRINTSi PR01703. MNSODISMTASE.
    SUPFAMi SSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEi PS00088. SOD_MN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a second superoxide dismutase gene (sodM) from Staphylococcus aureus."
      Wright Valderas M., Hart M.E.
      J. Bacteriol. 183:3399-3407(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, EXPRESSION, SOD ACTIVITY.
    2. "The Staphylococcus aureus NCTC 8325 genome."
      Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
      (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 8325.
    3. "Characterization of superoxide dismutase genes from Gram-positive bacteria by polymerase chain reaction using degenerate primers."
      Poyart C., Berche P., Trieu-Cuot P.
      FEMS Microbiol. Lett. 131:41-45(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-160.
    4. "The superoxide dismutase gene sodM is unique to Staphylococcus aureus: absence of sodM in coagulase-negative staphylococci."
      Wright Valderas M., Gatson J.W., Wreyford N., Hart M.E.
      J. Bacteriol. 184:2465-2472(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SOD ACTIVITY, SUBUNIT.
    5. "Role and regulation of the superoxide dismutases of Staphylococcus aureus."
      Karavolos M.H., Horsburgh M.J., Ingham E., Foster S.J.
      Microbiology 149:2749-2758(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN OXIDATIVE STRESS RESISTANCE, EXPRESSION, REGULATION.

    Entry informationi

    Entry nameiSODM2_STAA8
    AccessioniPrimary (citable) accession number: Q2G261
    Secondary accession number(s): Q59806, Q9EZZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    According to PubMed:11344148 the levels of SodM activity and sodM expression are growth-phase dependent, occurring most during the late-exponential and stationary phases. This response is also dependent on the level of aeration with highest activity occurring under high aeration. SodM expression under low-aeration growth conditions is most abundant during the late-exponential phase while under high-aeration growth conditions is highest during the stationary phase.
    Transcribed from a single sigmaA-type promoter (PM). Transcriptional data show an indirect repression of PM promoter by sigmaB which can also be involved in the post-transcriptional regulation of SodM homodimer activity.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3