Q2G1Z9 (PPNK_STAA8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	SAOUHSC_00943

Organism

Staphylococcus aureus (strain NCTC 8325)

Taxonomic identifier

93061 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_1000005446

Sequences

	Sequence		Length	Mass (Da)
	Q2G1Z9 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: DC51C17C51D7F7FA	FASTA	269	30,769
	10 20 30 40 50 60 MRYTILTKGD SKSNALKHKM MNYMKDFRMI EDSENPEIVI SVGGDGTLLQ AFHQYSHMLS 70 80 90 100 110 120 KVAFVGVHTG HLGFYADWLP HEVEKLIIEI NNSEFQVIEY PLLEIIMRYN DNGYETRYLA 130 140 150 160 170 180 LNEATMKTEN GSTLVVDVNL RGKHFERFRG DGLCVSTPSG STAYNKALGG ALIHPSLEAM 190 200 210 220 230 240 QITEIASINN RVFRTVGSPL VLPKHHTCLI SPVNHDTIRM TIDHVSIKHK NVNSIQYRVA 250 260 NEKVRFARFR PFPFWKRVHD SFISSDEER

References

[1]	"The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 8325.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000253 Genomic DNA. Translation: ABD30068.1.
RefSeq	YP_499496.1. NC_007795.1.
3D structure databases
ProteinModelPortal	Q2G1Z9.
SMR	Q2G1Z9. Positions 1-263.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2G1Z9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000029841; EBSTAP00000028792; EBSTAG00000029839.
GeneID	3920772.
GenomeReviews	Gene locus SAOUHSC_00943 in contig CP000253_GR.
KEGG	sao:SAOUHSC_00943.
PATRIC	19579406. VBIStaAur99865_0864.
Phylogenomic databases
eggNOG	COG0061.
GeneTree	EBGT00050000025514.
HOGENOM	HBG314020.
OMA	TISFANC.
PhylomeDB	Q2G1Z9.
ProtClustDB	PRK04885.
Enzyme and pathway databases
BioCyc	SAUR93061:SAOUHSC_00943-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_STAA8

Accession

Primary (citable) accession number: Q2G1Z9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program