ID   GTAB_STAA8              Reviewed;         288 AA.
AC   Q2G1T6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   16-JUN-2009, entry version 17.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase;
DE            EC=2.7.7.9;
DE   AltName: Full=UDP-glucose pyrophosphorylase;
DE            Short=UDPGP;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase;
GN   Name=gtaB; OrderedLocusNames=SAOUHSC_02801;
OS   Staphylococcus aureus (strain NCTC 8325).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W.,
RA   Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC8325 genome.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION IN GLYCOLIPID AND LTA BIOSYNTHESIS, AND PATHWAY.
RX   PubMed=17209021; DOI=10.1128/JB.01683-06;
RA   Gruendling A., Schneewind O.;
RT   "Genes required for glycolipid synthesis and lipoteichoic acid
RT   anchoring in Staphylococcus aureus.";
RL   J. Bacteriol. 189:2521-2530(2007).
CC   -!- FUNCTION: Catalyzes the formation of UDP-glucose from glucose-1-
CC       phosphate and UTP (Probable). This is an intermediate step in the
CC       biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the
CC       predominant glycolipid found in the S.aureus membrane, which is
CC       also used as a membrane anchor for lipoteichoic acid (LTA).
CC   -!- CATALYTIC ACTIVITY: UTP + alpha-D-glucose 1-phosphate =
CC       diphosphate + UDP-glucose.
CC   -!- PATHWAY: Glycolipid metabolism; diglucosyl-diacylglycerol
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family.
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DR   EMBL; CP000253; ABD31804.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_501260.1; -.
DR   GeneID; 3921455; -.
DR   GenomeReviews; CP000253_GR; SAOUHSC_02801.
DR   KEGG; sao:SAOUHSC_02801; -.
DR   HOGENOM; Q2G1T6; -.
DR   BioCyc; SAUR93061:SAOUHSC_02801-MON; -.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase...; IEA:EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   InterPro; IPR005771; GalU_trans_bac.
DR   InterPro; IPR005835; NTP_transferase.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   TIGRFAMs; TIGR01099; galU; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Complete proteome; Nucleotidyltransferase;
KW   Transferase.
FT   CHAIN         1    288       UTP--glucose-1-phosphate
FT                                uridylyltransferase.
FT                                /FTId=PRO_0000308301.
SQ   SEQUENCE   288 AA;  32451 MW;  126BF005599D4418 CRC64;
     MKKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEAARAGI EDIIIVTGRH
     KRAIEDHFDS QKELEMVLKE KGKSELLEKV QYSTELANIF YVRQKEQKGL GHAISSARQF
     IGNEPFAVLL GDDIVESEVP AVKQLIDVYE ETGHSVIGVQ EVPEADTHRY GIIDPLTKNG
     RQYEVKKFVE KPAQGTAPSN LAIMGRYVLT PEIFDYLKTQ KEGAGNEIQL TDAIERMNND
     NQVYAYDFEG ERYDVGEKLG FVKTTIEYAL KDDSMREELT RFIKALGL
//