Reviewed, UniProtKB/Swiss-Prot Q2G1J0 (ALDA_STAA8)

Names and origin

Protein names

Recommended name:
    Putative aldehyde dehydrogenase aldA
    EC=1.2.1.3

Gene names

Name:	aldA
Ordered Locus Names:	SAOUHSC_00132

Organism

Staphylococcus aureus (strain NCTC 8325) [Complete proteome] [HAMAP]

Taxonomic identifier

93061 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	Putative aldehyde dehydrogenase aldA		PRO_0000290788
Regions
	Nucleotide binding	212 – 218	7	NAD By similarity
Sites
	Active site	256	1	By similarity
	Active site	290	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2G1J0-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: DCBE4F433645A52A	FASTA	495	53,659
	10 20 30 40 50 60 MAVNVRDYIA ENYGLFINGE FVKGSSDETI EVTNPATGET LSHITRAKDK DVDHAVKVAQ 70 80 90 100 110 120 EAFESWSLTS KSERAQMLRD IGDKLMAQKD KIAMIETLNN GKPIRETTAI DIPFAARHFH 130 140 150 160 170 180 YFASVIETEE GTVNDIDKDT MSIVRHEPIG VVGAVVAWNF PMLLAAWKIA PAIAAGNTIV 190 200 210 220 230 240 IQPSSSTPLS LLEVAKIFQE VLPKGVVNIL TGKGSESGNA IFNHDGVDKL SFTGSTDVGY 250 260 270 280 290 300 QVAEAAAKHL VPATLELGGK SANIILDDAN LDLAVEGIQL GILFNQGEVC SAGSRLLVHE 310 320 330 340 350 360 KIYDQLVPRL QEAFSNIKVG NPQDEATQMG SQTGKDQLDK IQSYIDAAKE SDAQILAGGH 370 380 390 400 410 420 RLTENGLDKG FFFEPTLIAV PDNHHKLAQE EIFGPVLTVI KVKDDQEAID IANDSEYGLA 430 440 450 460 470 480 GGVFSQNITR ALNIAKAVRT GRIWINTYNQ VPEGAPFGGY KKSGIGRETY KGALSNYQQV 490 KNIYIDTSNA LKGLY

References

[1]	"The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000253 Genomic DNA. Translation: ABD29313.1.
RefSeq	YP_498732.1.
3D structure databases
HSSP	HSSP built from PDB template 2D4E based on UniProtKB Q5SJP9.
SMR	Q2G1J0. Positions 14-489.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2G1J0.
Genome annotation databases
GeneID	3919841.
GenomeReviews	Gene locus SAOUHSC_00132 in contig CP000253_GR.
KEGG	sao:SAOUHSC_00132.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HBG752218.
OMA	EDSNANI.
Enzyme and pathway databases
BioCyc	SAUR93061:SAOUHSC_00132-MONOMER.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDA_STAA8

Accession

Primary (citable) accession number: Q2G1J0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	March 21, 2006
Last modified:	January 19, 2010
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)