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Protein

Ribitol-5-phosphate cytidylyltransferase 1

Gene

tarI

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.UniRule annotation1 Publication

Catalytic activityi

CTP + D-ribitol 5-phosphate = diphosphate + CDP-ribitol.UniRule annotation1 Publication

Kineticsi

  1. KM=78.9 µM for CTP1 Publication
  2. KM=1.28 mM for D-ribitol 5-phosphate1 Publication

    Pathwayi: poly(ribitol phosphate) teichoic acid biosynthesis

    This protein is involved in the pathway poly(ribitol phosphate) teichoic acid biosynthesis, which is part of Cell wall biogenesis.UniRule annotation1 Publication
    View all proteins of this organism that are known to be involved in the pathway poly(ribitol phosphate) teichoic acid biosynthesis and in Cell wall biogenesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sitei14Transition state stabilizerUniRule annotation1
    Sitei22Transition state stabilizerUniRule annotation1
    Binding sitei112CTPUniRule annotation1
    Sitei160Positions ribitol 5-phosphate for the nucleophilic attackUniRule annotation1
    Sitei217Positions ribitol 5-phosphate for the nucleophilic attackUniRule annotation1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi7 – 10CTPUniRule annotation4
    Nucleotide bindingi81 – 87CTPUniRule annotation7

    GO - Molecular functioni

    GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Cell wall biogenesis/degradation, Teichoic acid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00790.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribitol-5-phosphate cytidylyltransferase 11 PublicationUniRule annotation (EC:2.7.7.40UniRule annotation1 Publication)
    Gene namesi
    Name:tarI1 Publication
    Ordered Locus Names:SAOUHSC_00225
    OrganismiStaphylococcus aureus (strain NCTC 8325)
    Taxonomic identifieri93061 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
    Proteomesi
    • UP000008816 Componenti: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_10000229501 – 238Ribitol-5-phosphate cytidylyltransferase 1Add BLAST238

    Interactioni

    Subunit structurei

    Heterodimer together with TarJ.1 Publication

    Protein-protein interaction databases

    STRINGi93061.SAOUHSC_00225.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2G1C0.
    SMRiQ2G1C0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IspD/TarI cytidylyltransferase family. TarI subfamily.UniRule annotationCurated

    Phylogenomic databases

    eggNOGiENOG4108QHG. Bacteria.
    COG1211. LUCA.
    HOGENOMiHOG000218563.
    KOiK00991.
    OMAiPQVFDAD.

    Family and domain databases

    CDDicd02516. CDP-ME_synthetase. 1 hit.
    Gene3Di3.90.550.10. 1 hit.
    HAMAPiMF_02068. TarI. 1 hit.
    InterProiIPR001228. IspD.
    IPR018294. ISPD_synthase_CS.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF01128. IspD. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    PROSITEiPS01295. ISPD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2G1C0-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MKYAGILAGG IGSRMGNVPL PKQFLDLDNK PILIHTLEKF ILINDFEKII
    60 70 80 90 100
    IATPQQWMTH TKDTLRKFKI SDERIEVIQG GSDRNDTIMN IVKHIESTNG
    110 120 130 140 150
    INDDDVIVTH DAVRPFLTHR IIKENIQAAL EYGAVDTVID AIDTIVTSKD
    160 170 180 190 200
    NQTIDAIPVR NEMYQGQTPQ SFNINLLKES YAQLSDEQKS ILSDACKIIV
    210 220 230
    ETNKPVRLVK GELYNIKVTT PYDLKVANAI IRGGIADD
    Length:238
    Mass (Da):26,657
    Last modified:March 21, 2006 - v1
    Checksum:iB19F7EA82D847A0F
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CP000253 Genomic DNA. Translation: ABD29400.1.
    RefSeqiWP_000872486.1. NC_007795.1.
    YP_498820.1. NC_007795.1.

    Genome annotation databases

    EnsemblBacteriaiABD29400; ABD29400; SAOUHSC_00225.
    GeneIDi28379428.
    3920300.
    KEGGisao:SAOUHSC_00225.
    PATRICi19578060. VBIStaAur99865_0206.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CP000253 Genomic DNA. Translation: ABD29400.1.
    RefSeqiWP_000872486.1. NC_007795.1.
    YP_498820.1. NC_007795.1.

    3D structure databases

    ProteinModelPortaliQ2G1C0.
    SMRiQ2G1C0.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi93061.SAOUHSC_00225.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblBacteriaiABD29400; ABD29400; SAOUHSC_00225.
    GeneIDi28379428.
    3920300.
    KEGGisao:SAOUHSC_00225.
    PATRICi19578060. VBIStaAur99865_0206.

    Phylogenomic databases

    eggNOGiENOG4108QHG. Bacteria.
    COG1211. LUCA.
    HOGENOMiHOG000218563.
    KOiK00991.
    OMAiPQVFDAD.

    Enzyme and pathway databases

    UniPathwayiUPA00790.

    Family and domain databases

    CDDicd02516. CDP-ME_synthetase. 1 hit.
    Gene3Di3.90.550.10. 1 hit.
    HAMAPiMF_02068. TarI. 1 hit.
    InterProiIPR001228. IspD.
    IPR018294. ISPD_synthase_CS.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF01128. IspD. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    PROSITEiPS01295. ISPD. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiTARI1_STAA8
    AccessioniPrimary (citable) accession number: Q2G1C0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 21, 2006
    Last modified: November 2, 2016
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.