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Protein

Ribitol-5-phosphate cytidylyltransferase 1

Gene

tarI

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.UniRule annotation1 Publication

Catalytic activityi

CTP + D-ribitol 5-phosphate = diphosphate + CDP-ribitol.UniRule annotation1 Publication

Kineticsi

  1. KM=78.9 µM for CTP1 Publication
  2. KM=1.28 mM for D-ribitol 5-phosphate1 Publication

    Pathwayi: poly(ribitol phosphate) teichoic acid biosynthesis

    This protein is involved in the pathway poly(ribitol phosphate) teichoic acid biosynthesis, which is part of Cell wall biogenesis.UniRule annotation1 Publication
    View all proteins of this organism that are known to be involved in the pathway poly(ribitol phosphate) teichoic acid biosynthesis and in Cell wall biogenesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sitei14Transition state stabilizerUniRule annotation1
    Sitei22Transition state stabilizerUniRule annotation1
    Sitei160Positions ribitol 5-phosphate for the nucleophilic attackUniRule annotation1
    Sitei217Positions ribitol 5-phosphate for the nucleophilic attackUniRule annotation1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi7 – 10CTPUniRule annotation4
    Nucleotide bindingi81 – 87CTPUniRule annotation7

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionNucleotidyltransferase, Transferase
    Biological processCell wall biogenesis/degradation, Teichoic acid biosynthesis

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-19987
    SAUR93061:G1G5Y-209-MONOMER
    UniPathwayiUPA00790

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribitol-5-phosphate cytidylyltransferase 11 PublicationUniRule annotation (EC:2.7.7.40UniRule annotation1 Publication)
    Gene namesi
    Name:tarI1 Publication
    Ordered Locus Names:SAOUHSC_00225
    OrganismiStaphylococcus aureus (strain NCTC 8325)
    Taxonomic identifieri93061 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
    Proteomesi
    • UP000008816 Componenti: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_10000229501 – 238Ribitol-5-phosphate cytidylyltransferase 1Add BLAST238

    Interactioni

    Subunit structurei

    Heterodimer together with TarJ.1 Publication

    Protein-protein interaction databases

    STRINGi93061.SAOUHSC_00225

    Structurei

    3D structure databases

    ProteinModelPortaliQ2G1C0
    SMRiQ2G1C0
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IspD/TarI cytidylyltransferase family. TarI subfamily.UniRule annotationCurated

    Phylogenomic databases

    eggNOGiENOG4108QHG Bacteria
    COG1211 LUCA
    HOGENOMiHOG000218563
    KOiK21030
    OMAiTNTMMVD

    Family and domain databases

    CDDicd02516 CDP-ME_synthetase, 1 hit
    Gene3Di3.90.550.10, 1 hit
    HAMAPiMF_02068 TarI, 1 hit
    InterProiView protein in InterPro
    IPR034683 IspD/TarI
    IPR018294 ISPD_synthase_CS
    IPR029044 Nucleotide-diphossugar_trans
    IPR034709 TarI
    PfamiView protein in Pfam
    PF01128 IspD, 1 hit
    SUPFAMiSSF53448 SSF53448, 1 hit
    PROSITEiView protein in PROSITE
    PS01295 ISPD, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q2G1C0-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MKYAGILAGG IGSRMGNVPL PKQFLDLDNK PILIHTLEKF ILINDFEKII
    60 70 80 90 100
    IATPQQWMTH TKDTLRKFKI SDERIEVIQG GSDRNDTIMN IVKHIESTNG
    110 120 130 140 150
    INDDDVIVTH DAVRPFLTHR IIKENIQAAL EYGAVDTVID AIDTIVTSKD
    160 170 180 190 200
    NQTIDAIPVR NEMYQGQTPQ SFNINLLKES YAQLSDEQKS ILSDACKIIV
    210 220 230
    ETNKPVRLVK GELYNIKVTT PYDLKVANAI IRGGIADD
    Length:238
    Mass (Da):26,657
    Last modified:March 21, 2006 - v1
    Checksum:iB19F7EA82D847A0F
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CP000253 Genomic DNA Translation: ABD29400.1
    RefSeqiWP_000872486.1, NC_007795.1
    YP_498820.1, NC_007795.1

    Genome annotation databases

    EnsemblBacteriaiABD29400; ABD29400; SAOUHSC_00225
    GeneIDi3920300
    KEGGisao:SAOUHSC_00225
    PATRICifig|93061.5.peg.206

    Similar proteinsi

    Entry informationi

    Entry nameiTARI1_STAA8
    AccessioniPrimary (citable) accession number: Q2G1C0
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 21, 2006
    Last modified: March 28, 2018
    This is version 73 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

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