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Protein

Xanthine phosphoribosyltransferase

Gene

xpt

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Pathwayi: XMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from xanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Xanthine phosphoribosyltransferase (xpt)
This subpathway is part of the pathway XMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from xanthine, the pathway XMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei27XanthineUniRule annotation1
Binding sitei156XanthineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

UniPathwayiUPA00602; UER00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
Short name:
XPRTaseUniRule annotation
Gene namesi
Name:xptUniRule annotation
Ordered Locus Names:SAOUHSC_00372
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003397511 – 192Xanthine phosphoribosyltransferaseAdd BLAST192

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi93061.SAOUHSC_00372.

Structurei

3D structure databases

ProteinModelPortaliQ2G0Y9.
SMRiQ2G0Y9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni128 – 1325-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UPS. Bacteria.
COG0503. LUCA.
HOGENOMiHOG000036777.
KOiK03816.
OMAiHQIDPEL.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01184. XPRTase. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01744. XPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2G0Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLGQKVKE DGVVIDEKIL KVDGFLNHQI DAKLMNEVGR TFYEQFKDKG
60 70 80 90 100
ITKILTIEAS GIAPAIMAAL HFDVPCLFAK KAKPSTLTDG YYETSIHSFT
110 120 130 140 150
KNKTSTVIVS KEFLSEEDTV LIIDDFLANG DASLGLYDIA QQANAKTAGI
160 170 180 190
GIVVEKSFQN GHQRLEEAGL TVSSLCKVAS LEGNKVTLVG EE
Length:192
Mass (Da):20,884
Last modified:March 21, 2006 - v1
Checksum:i8E56855976C6BEC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD29538.1.
RefSeqiWP_000421410.1. NC_007795.1.
YP_498961.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD29538; ABD29538; SAOUHSC_00372.
GeneIDi28379280.
3919791.
KEGGisao:SAOUHSC_00372.
PATRICi19578332. VBIStaAur99865_0342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD29538.1.
RefSeqiWP_000421410.1. NC_007795.1.
YP_498961.1. NC_007795.1.

3D structure databases

ProteinModelPortaliQ2G0Y9.
SMRiQ2G0Y9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_00372.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD29538; ABD29538; SAOUHSC_00372.
GeneIDi28379280.
3919791.
KEGGisao:SAOUHSC_00372.
PATRICi19578332. VBIStaAur99865_0342.

Phylogenomic databases

eggNOGiENOG4108UPS. Bacteria.
COG0503. LUCA.
HOGENOMiHOG000036777.
KOiK03816.
OMAiHQIDPEL.

Enzyme and pathway databases

UniPathwayiUPA00602; UER00658.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01184. XPRTase. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01744. XPRTase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiXPT_STAA8
AccessioniPrimary (citable) accession number: Q2G0Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 21, 2006
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.