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Protein

ATP-dependent Clp protease ATP-binding subunit ClpC

Gene

clpC

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. Required for biofilm formation. May act as a chaperone regulating CtsR activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi208 – 215ATPSequence analysis8
Nucleotide bindingi545 – 552ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • pathogenesis Source: UniProtKB-KW
  • protein metabolic process Source: InterPro
  • stress response to cadmium ion Source: UniProtKB
  • stress response to copper ion Source: UniProtKB

Keywordsi

Molecular functionChaperone
Biological processStress response, Virulence
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-477-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpC
Gene namesi
Name:clpC
Ordered Locus Names:SAOUHSC_00505
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002696791 – 818ATP-dependent Clp protease ATP-binding subunit ClpCAdd BLAST818

Expressioni

Inductioni

By heat shock. Transcriptionally regulated by CtsR (PubMed:15554981). Up-regulated by heavy metals such as Cu2+ and Cd2+, but Zn2+ and Co2+ have no effect (PubMed:22126623). Forms part of an operon with ctsR, mcsA and mcsB.2 Publications

Interactioni

Subunit structurei

May interact with ClpP.1 Publication

Protein-protein interaction databases

STRINGi93061.SAOUHSC_00505

Structurei

3D structure databases

ProteinModelPortaliQ2G0P5
SMRiQ2G0P5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini417 – 452UVRPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni163 – 410IAdd BLAST248
Regioni471 – 662IIAdd BLAST192

Sequence similaritiesi

Belongs to the ClpA/ClpB family. ClpC subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105C2Z Bacteria
COG0542 LUCA
HOGENOMiHOG000218210
KOiK03696
OMAiHHKVRIK

Family and domain databases

Gene3Di1.10.1780.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR004176 Clp_N
IPR036628 Clp_N_dom_sf
IPR001270 ClpA/B
IPR018368 ClpA/B_CS1
IPR028299 ClpA/B_CS2
IPR027417 P-loop_NTPase
IPR001943 UVR_dom
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF07724 AAA_2, 1 hit
PF02861 Clp_N, 2 hits
PF10431 ClpB_D2-small, 1 hit
PF02151 UVR, 1 hit
PRINTSiPR00300 CLPPROTEASEA
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SM01086 ClpB_D2-small, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF81923 SSF81923, 1 hit
PROSITEiView protein in PROSITE
PS00870 CLPAB_1, 1 hit
PS00871 CLPAB_2, 1 hit
PS50151 UVR, 1 hit

Sequencei

Sequence statusi: Complete.

Q2G0P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFGRLTERA QRVLAHAQEE AIRLNHSNIG TEHLLLGLMK EPEGIAAKVL
60 70 80 90 100
ESFNITEDKV IEEVEKLIGH GQDHVGTLHY TPRAKKVIEL SMDEARKLHH
110 120 130 140 150
NFVGTEHILL GLIRENEGVA ARVFANLDLN ITKARAQVVK ALGNPEMSNK
160 170 180 190 200
NAQASKSNNT PTLDSLARDL TVIAKDGTLD PVIGRDKEIT RVIEVLSRRT
210 220 230 240 250
KNNPVLIGEP GVGKTAIAEG LAQAIVNNEV PETLKDKRVM SLDMGTVVAG
260 270 280 290 300
TKYRGEFEER LKKVMEEIQQ AGNVILFIDE LHTLVGAGGA EGAIDASNIL
310 320 330 340 350
KPALARGELQ CIGATTLDEY RKNIEKDAAL ERRFQPVQVD EPSVVDTVAI
360 370 380 390 400
LKGLRDRYEA HHRINISDEA IEAAVKLSNR YVSDRFLPDK AIDLIDEASS
410 420 430 440 450
KVRLKSHTTP NNLKEIEQEI EKVKNEKDAA VHAQEFENAA NLRDKQTKLE
460 470 480 490 500
KQYEEAKNEW KNAQNGMSTS LSEEDIAEVI AGWTGIPLTK INETESEKLL
510 520 530 540 550
SLEDTLHERV IGQKDAVNSI SKAVRRARAG LKDPKRPIGS FIFLGPTGVG
560 570 580 590 600
KTELARALAE SMFGDDDAMI RVDMSEFMEK HAVSRLVGAP PGYVGHDDGG
610 620 630 640 650
QLTEKVRRKP YSVILFDEIE KAHPDVFNIL LQVLDDGHLT DTKGRTVDFR
660 670 680 690 700
NTIIIMTSNV GAQELQDQRF AGFGGSSDGQ DYETIRKTML KELKNSFRPE
710 720 730 740 750
FLNRVDDIIV FHKLTKEELK EIVTMMVNKL TNRLSEQNIN IIVTDKAKDK
760 770 780 790 800
IAEEGYDPEY GARPLIRAIQ KTIEDNLSEL ILDGNQIEGK KVTVDHDGKE
810
FKYDIAEQTS ETKTPSQA
Length:818
Mass (Da):91,037
Last modified:March 21, 2006 - v1
Checksum:i404DBB1643BAA31F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA Translation: ABD29654.1
RefSeqiWP_000897132.1, NC_007795.1
YP_499078.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD29654; ABD29654; SAOUHSC_00505
GeneIDi3920417
KEGGisao:SAOUHSC_00505
PATRICifig|93061.5.peg.452

Similar proteinsi

Entry informationi

Entry nameiCLPC_STAA8
AccessioniPrimary (citable) accession number: Q2G0P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health