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Protein

Alcohol dehydrogenase

Gene

adh

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi37Zinc 1; catalyticBy similarity1
Metal bindingi58Zinc 1; catalyticBy similarity1
Metal bindingi89Zinc 2By similarity1
Metal bindingi92Zinc 2By similarity1
Metal bindingi95Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi145Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Short name:
ADH
Gene namesi
Name:adh
Ordered Locus Names:SAOUHSC_00608
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002730331 – 336Alcohol dehydrogenaseAdd BLAST336

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_00608.

Structurei

3D structure databases

ProteinModelPortaliQ2G0G1.
SMRiQ2G0G1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DQ4. Bacteria.
COG1064. LUCA.
HOGENOMiHOG000294685.
KOiK13953.
OMAiATHCIVS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR029752. D-isomer_DH_CS1.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2G0G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAAVVTKDH KVSIEDKKLR ALKPGEALVQ TEYCGVCHTD LHVKNADFGD
60 70 80 90 100
VTGVTLGHEG IGKVIEVAED VESLKIGDRV SIAWMFESCG RCEYCTTGRE
110 120 130 140 150
TLCRSVKNAG YTVDGAMAEQ VIVTADYAVK VPEKLDPAAA SSITCAGVTT
160 170 180 190 200
YKAVKVSNVK PGQWLGVFGI GGLGNLALQY AKNVMGAKIV AFDINDDKLA
210 220 230 240 250
FAKELGADAI INSKDVDPVA EVMKLTDNKG LDATVVTSVA KTPFNQAVDV
260 270 280 290 300
VKAGARVVAV GLPVDKMNLD IPRLVLDGIE VVGSLVGTRQ DLREAFEFAA
310 320 330
ENKVTPKVQL RKLEEINDIF EEMENGTITG RMVIKF
Length:336
Mass (Da):36,048
Last modified:March 21, 2006 - v1
Checksum:iDB68A432F9E72EF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD29746.1.
RefSeqiWP_001200748.1. NC_007795.1.
YP_499171.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD29746; ABD29746; SAOUHSC_00608.
GeneIDi28379102.
3918927.
KEGGisao:SAOUHSC_00608.
PATRICi19578770. VBIStaAur99865_0545.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD29746.1.
RefSeqiWP_001200748.1. NC_007795.1.
YP_499171.1. NC_007795.1.

3D structure databases

ProteinModelPortaliQ2G0G1.
SMRiQ2G0G1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_00608.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD29746; ABD29746; SAOUHSC_00608.
GeneIDi28379102.
3918927.
KEGGisao:SAOUHSC_00608.
PATRICi19578770. VBIStaAur99865_0545.

Phylogenomic databases

eggNOGiENOG4105DQ4. Bacteria.
COG1064. LUCA.
HOGENOMiHOG000294685.
KOiK13953.
OMAiATHCIVS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR029752. D-isomer_DH_CS1.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH_STAA8
AccessioniPrimary (citable) accession number: Q2G0G1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 21, 2006
Last modified: February 15, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.