Q2G044 (LGT_STAA8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prolipoprotein diacylglyceryl transferase
EC=2.4.99.-

Gene names

Name:	lgt
Ordered Locus Names:	SAOUHSC_00782

Organism

Staphylococcus aureus (strain NCTC 8325)

Taxonomic identifier

93061 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins. HAMAP MF_01147
Pathway	Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer). HAMAP MF_01147
Subcellular location	Cell membrane; Multi-pass membrane protein Probable HAMAP MF_01147.
Sequence similarities	Belongs to the lgt family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipoprotein biosynthetic process Inferred from electronic annotation. Source: InterPro protein lipoylation Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transferase activity, transferring glycosyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Prolipoprotein diacylglyceryl transferase HAMAP MF_01147		PRO_0000289882
Regions
	Transmembrane	18 – 38	21	Helical; Potential
	Transmembrane	55 – 75	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Transmembrane	203 – 223	21	Helical; Potential
	Transmembrane	235 – 255	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2G044 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: D3D91BA6AC65A375	FASTA	279	31,572
	10 20 30 40 50 60 MGIVFNYIDP VAFNLGPLSV RWYGIIIAVG ILLGYFVAQR ALVKAGLHKD TLVDIIFYSA 70 80 90 100 110 120 LFGFIAARIY FVIFQWPYYA ENPSEIIKIW HGGIAIHGGL IGGFIAGVIV CKVKNLNPFQ 130 140 150 160 170 180 IGDIVAPSII LAQGIGRWGN FMNHEAHGGS VSRAFLEQLH LPNFIIENMY INGQYYHPTF 190 200 210 220 230 240 LYESIWDVAG FIILVNIRKH LKLGETFFLY LTWYSIGRFF IEGLRTDSLM LTSNIRVAQL 250 260 270 VSILLILISI SLIVYRRIKY NPPLYSKVGA LPWPTKKVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 8325.
[2]	"Staphylococcus aureus deficient in lipidation of prelipoproteins is attenuated in growth and immune activation." Stoll H., Dengjel J., Nerz C., Goetz F. Infect. Immun. 73:2411-2423(2005) [PubMed: 15784587] [Abstract] Cited for: EFFECT ON GROWTH AND HOST IMMUNE ACTIVATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000253 Genomic DNA. Translation: ABD29911.1.
RefSeq	YP_499339.1. NC_007795.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2G044.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000028664; EBSTAP00000027615; EBSTAG00000028663.
GeneID	3919072.
GenomeReviews	Gene locus SAOUHSC_00782 in contig CP000253_GR.
KEGG	sao:SAOUHSC_00782.
PATRIC	19579086. VBIStaAur99865_0703.
Phylogenomic databases
eggNOG	COG0682.
GeneTree	EBGT00050000025513.
HOGENOM	HBG450278.
OMA	HWYGIII.
PhylomeDB	Q2G044.
ProtClustDB	PRK00052.
Enzyme and pathway databases
BioCyc	SAUR93061:SAOUHSC_00782-MONOMER.
Family and domain databases
HAMAP	MF_01147. Lgt. [Tree]
InterPro	IPR001640. Prolipoprot_diAcglycer_Trfase. [Graphical view]
KO	K13292.
Pfam	PF01790. LGT. 1 hit. [Graphical view]
TIGRFAMs	TIGR00544. Lgt. 1 hit.
PROSITE	PS01311. LGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LGT_STAA8

Accession

Primary (citable) accession number: Q2G044

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program