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Protein

3-dehydroquinate dehydratase

Gene

aroD

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.UniRule annotation

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroD)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei703-dehydroquinateUniRule annotation1
Active sitei133Proton donor/acceptorUniRule annotation1
Active sitei160Schiff-base intermediate with substrateUniRule annotation1
Binding sitei2023-dehydroquinateUniRule annotation1
Binding sitei2253-dehydroquinateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandSchiff base

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-776-MONOMER
UniPathwayiUPA00053; UER00086

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydrataseUniRule annotation (EC:4.2.1.10UniRule annotation)
Short name:
3-dehydroquinaseUniRule annotation
Alternative name(s):
Type I DHQaseUniRule annotation
Type I dehydroquinaseUniRule annotation
Short name:
DHQ1UniRule annotation
Gene namesi
Name:aroDUniRule annotation
Ordered Locus Names:SAOUHSC_00832
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000431871 – 2383-dehydroquinate dehydrataseAdd BLAST238

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi93061.SAOUHSC_00832

Structurei

3D structure databases

ProteinModelPortaliQ2G002
SMRiQ2G002
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 373-dehydroquinate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the type-I 3-dehydroquinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105FF2 Bacteria
COG0710 LUCA
HOGENOMiHOG000105514
KOiK03785
OMAiATMAMGE

Family and domain databases

CDDicd00502 DHQase_I, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00214 AroD, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001381 DHquinase_I
PfamiView protein in Pfam
PF01487 DHquinase_I, 1 hit
TIGRFAMsiTIGR01093 aroD, 1 hit

Sequencei

Sequence statusi: Complete.

Q2G002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHVEVVATI APQLSIEETL IQKINHRIDA IDVLELRIDQ IENVTVDQVA
60 70 80 90 100
EMITKLKVMQ DSFKLLVTYR TKLQGGYGQF TNDSYLNLIS DLANINGIDM
110 120 130 140 150
IDIEWQADID IEKHQRIITH LQQYNKEVVI SHHNFESTPP LDELQFIFFK
160 170 180 190 200
MQKFNPEYVK LAVMPHNKND VLNLLQAMST FSDTMDCKVV GISMSKLGLI
210 220 230
SRTAQGVFGG ALTYGCIGVP QAPGQIDVTD LKAQVTLY
Length:238
Mass (Da):26,869
Last modified:March 21, 2006 - v1
Checksum:i108F24B67BDD76A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA Translation: ABD29958.1
RefSeqiWP_000150017.1, NC_007795.1
YP_499386.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD29958; ABD29958; SAOUHSC_00832
GeneIDi3918944
KEGGisao:SAOUHSC_00832
PATRICifig|93061.5.peg.752

Similar proteinsi

Entry informationi

Entry nameiAROD_STAA8
AccessioniPrimary (citable) accession number: Q2G002
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health