Reviewed,
UniProtKB/Swiss-Prot Q2FZW4 (DLTC_STAA8)
Last modified
June 16, 2009.
Version 24.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: D-alanine--poly(phosphoribitol) ligase subunit 2 EC=6.1.1.13 Alternative name(s): D-alanyl carrier protein Short name=DCP | ||||
| Gene names |
| ||||
| Organism | Staphylococcus aureus (strain NCTC 8325) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 93061 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Staphylococcus |
Protein attributes
| Sequence length | 78 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA By similarity. |
| Catalytic activity | ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate). HAMAP MF_00565 |
| Pathway | Cell wall biogenesis; lipoteichoic acid biosynthesis. HAMAP MF_00565 |
| Post-translational modification | 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-DCP By similarity. |
| Sequence similarities | Contains 1 acyl carrier domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell shape Cell wall biogenesis/degradation |
| Ligand | ATP-binding Nucleotide-binding Phosphopantetheine |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shapeInferred from electronic annotation. Source: UniProtKB-KW teichoic acid biosynthetic processInferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW D-alanine-poly(phosphoribitol) ligase activityInferred from electronic annotation. Source: HAMAP acyl carrier activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 78 | 78 | D-alanine--poly(phosphoribitol) ligase subunit 2 HAMAP MF_00565 | PRO_0000289881 | |||||
Amino acid modifications | |||||||||
| Modified residue | 36 | 1 | O-(pantetheine 4'-phosphoryl)serine Probable | ||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides." Peschel A., Otto M., Jack R.W., Kalbacher H., Jung G., Goetz F. J. Biol. Chem. 274:8405-8410(1999) [PubMed: 10085071] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AF101234 Genomic DNA. Translation: AAD21959.1. CP000253 Genomic DNA. Translation: ABD29996.1. | |
| RefSeq | YP_499424.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3919218. |
| GenomeReviews | Gene locus SAOUHSC_00871 in contig CP000253_GR. |
| KEGG | sao:SAOUHSC_00871. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q2FZW4. |
| OMA | Q2FZW4. EWDTPNK. |
Enzyme and pathway databases | |
| BioCyc | SAUR93061:SAOUHSC_00871-MON. |
Family and domain databases | |
| HAMAP | MF_00565. [Tree] |
| InterPro | IPR003230. D-ala_carrier. [Graphical view] |
| ProDom | PD015103. D-ala_carrier. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR01688. dltC. 1 hit. |
| PROSITE | PS50075. ACP_DOMAIN. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DLTC_STAA8 | ||||||||
| Accession | Primary (citable) accession number: Q2FZW4 Secondary accession number(s): P0A021, Q53663 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


