Reviewed, UniProtKB/Swiss-Prot Q2FZW4 (DLTC_STAA8)

Names and origin

Protein names

Recommended name:
    D-alanine--poly(phosphoribitol) ligase subunit 2
    EC=6.1.1.13
Alternative name(s):
    D-alanyl carrier protein
      Short name=DCP

Gene names

Name:	dltC
Ordered Locus Names:	SAOUHSC_00871

Organism

Staphylococcus aureus (strain NCTC 8325) [Complete proteome] [HAMAP]

Taxonomic identifier

93061 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	78 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA By similarity.
Catalytic activity	ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate). HAMAP MF_00565
Pathway	Cell wall biogenesis; lipoteichoic acid biosynthesis. HAMAP MF_00565
Post-translational modification	4'-phosphopantetheine is transferred from CoA to a specific serine of apo-DCP By similarity.
Sequence similarities	Contains 1 acyl carrier domain.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation
Ligand	ATP-binding Nucleotide-binding Phosphopantetheine
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW teichoic acid biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW D-alanine-poly(phosphoribitol) ligase activity Inferred from electronic annotation. Source: HAMAP acyl carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 78	78	D-alanine--poly(phosphoribitol) ligase subunit 2 HAMAP MF_00565		PRO_0000289881
Amino acid modifications
	Modified residue	36	1	O-(pantetheine 4'-phosphoryl)serine Probable

Sequences

	Sequence		Length	Mass (Da)
	Q2FZW4-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: C001D1D3D189A584	FASTA	78	9,063
	10 20 30 40 50 60 MEFREQVLNL LAEVAENDIV KENPDVEIFE EGIIDSFQTV GLLLEIQNKL DIEVSIMDFD 70 RDEWATPNKI VEALEELR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides." Peschel A., Otto M., Jack R.W., Kalbacher H., Jung G., Goetz F. J. Biol. Chem. 274:8405-8410(1999) [PubMed: 10085071] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF101234 Genomic DNA. Translation: AAD21959.1. CP000253 Genomic DNA. Translation: ABD29996.1.
RefSeq	YP_499424.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3919218.
GenomeReviews	Gene locus SAOUHSC_00871 in contig CP000253_GR.
KEGG	sao:SAOUHSC_00871.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2FZW4.
OMA	Q2FZW4. EWDTPNK.
Enzyme and pathway databases
BioCyc	SAUR93061:SAOUHSC_00871-MON.
Family and domain databases
HAMAP	MF_00565. [Tree]
InterPro	IPR003230. D-ala_carrier. [Graphical view]
ProDom	PD015103. D-ala_carrier. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01688. dltC. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DLTC_STAA8

Accession

Primary (citable) accession number: Q2FZW4
Secondary accession number(s): P0A021, Q53663

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	March 21, 2006
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)