Q2FZW4 (DLTC_STAA8) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 41.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: D-alanine--poly(phosphoribitol) ligase subunit 2 EC=6.1.1.13 Alternative name(s): D-alanyl carrier protein Short name=DCP | ||||
| Gene names |
| ||||
| Organism | Staphylococcus aureus (strain NCTC 8325) | ||||
| Taxonomic identifier | 93061 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Staphylococcus |
Protein attributes
| Sequence length | 78 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA By similarity. HAMAP MF_00565 |
| Catalytic activity | ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate). HAMAP MF_00565 |
| Pathway | Cell wall biogenesis; lipoteichoic acid biosynthesis. HAMAP MF_00565 |
| Post-translational modification | 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-DCP By similarity. HAMAP MF_00565 |
| Sequence similarities | Contains 1 acyl carrier domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell shape Cell wall biogenesis/degradation |
| Ligand | ATP-binding Nucleotide-binding Phosphopantetheine |
| Molecular function | Ligase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shapeInferred from electronic annotation. Source: UniProtKB-KW teichoic acid biosynthetic processInferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW D-alanine-poly(phosphoribitol) ligase activityInferred from electronic annotation. Source: EC acyl carrier activityInferred from electronic annotation. Source: InterPro cofactor bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 78 | 78 | D-alanine--poly(phosphoribitol) ligase subunit 2 HAMAP MF_00565 | PRO_0000289881 | |||||
Amino acid modifications | |||||||||
| Modified residue | 36 | 1 | O-(pantetheine 4'-phosphoryl)serine Probable | ||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides." Peschel A., Otto M., Jack R.W., Kalbacher H., Jung G., Goetz F. J. Biol. Chem. 274:8405-8410(1999) [PubMed: 10085071] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 8325. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF101234 Genomic DNA. Translation: AAD21959.1. CP000253 Genomic DNA. Translation: ABD29996.1. |
| RefSeq | YP_499424.1. NC_007795.1. |
3D structure databases | |
| ProteinModelPortal | Q2FZW4. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q2FZW4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBSTAT00000028492; EBSTAP00000027443; EBSTAG00000028491. |
| GeneID | 3919218. |
| GenomeReviews | Gene locus SAOUHSC_00871 in contig CP000253_GR. |
| KEGG | sao:SAOUHSC_00871. |
| PATRIC | 19579260. VBIStaAur99865_0791. |
Phylogenomic databases | |
| eggNOG | COG0236. |
| GeneTree | EBGT00050000025022. |
| HOGENOM | HBG516530. |
| OMA | QMDENIF. |
| ProtClustDB | PRK05087. |
Enzyme and pathway databases | |
| BioCyc | SAUR93061:SAOUHSC_00871-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00565. DltC. [Tree] |
| InterPro | IPR009081. Acyl_carrier_prot-like. IPR003230. D-ala_carrier. IPR006163. Phsphopanteth-bd. [Graphical view] |
| Gene3D | G3DSA:1.10.1200.10. ACP_like. 1 hit. |
| KO | K14188. |
| Pfam | PF00550. PP-binding. 1 hit. [Graphical view] |
| SUPFAM | SSF47336. ACP_like. 1 hit. |
| TIGRFAMs | TIGR01688. DltC. 1 hit. |
| PROSITE | PS50075. ACP_DOMAIN. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DLTC_STAA8 | ||||||||
| Accession | Primary (citable) accession number: Q2FZW4 Secondary accession number(s): P0A021, Q53663 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with