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Reviewed, UniProtKB/Swiss-Prot Q2FYS1 (TYRA_STAA8)

Last modified January 19, 2010. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Prephenate dehydrogenase
      Short name=PDH
    EC=1.3.1.12
Gene names
Name: tyrA
Ordered Locus Names: SAOUHSC_01364
OrganismStaphylococcus aureus (strain NCTC 8325) [Complete proteome] [HAMAP]
Taxonomic identifier93061 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesStaphylococcus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existencePredicted.

General annotation (Comments)

Catalytic activity

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathway

Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.

Sequence similarities

Contains 1 prephenate/arogenate dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Prephenate dehydrogenase
PRO_0000282661

Regions

Domain2 – 291290Prephenate/arogenate dehydrogenase
Nucleotide binding3 – 3331NAD Potential

Sequences

Sequence LengthMass (Da)Tools
Q2FYS1-1 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 07DEF8CC0AB6293E

FASTA36340,407
        10         20         30         40         50         60 
MTTVLFVGLG LIGGSLASNI KYHNPNTNII AYDADISQLD KAKSIGIINE KCLNYSEAIK 

        70         80         90        100        110        120 
KADVIIYATP VAITNKYLSE LIDMPTKPGV IVSDTGSTKA MIQQHECNLL KHNIHLVSGH 

       130        140        150        160        170        180 
PMAGSHKSGV LNAKKHLFEN AYYILVYNEP RNEQAANTLK ELLSPTLAKF IVTTAEEHDY 

       190        200        210        220        230        240 
VTSVVSHLPH IVASSLVHVS QKNGQEHHLV NKLAAGGFRD ITRIASSNAQ MWKDITLSNK 

       250        260        270        280        290        300 
TYILEMIRQL KSQFQDLERL IESNDSEKLL SFFAQAKSYR DALPAKQLGG LNTAYDLYVD 

       310        320        330        340        350        360 
IPDESGMISK VTYILSLHNI SISNLRILEV REDIYGALKI SFKNPTDRER GMQALSDFDC 


YIQ 

« Hide

References

[1]"The Staphylococcus aureus NCTC8325 genome."
Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000253 Genomic DNA. Translation: ABD30459.1.
RefSeqYP_499891.1.

3D structure databases

HSSPHSSP built from PDB template 2G5C based on UniProtKB O67636.
SMRQ2FYS1. Positions 3-295.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2FYS1.

Genome annotation databases

GeneID3920069.
GenomeReviewsGene locus SAOUHSC_01364 in contig CP000253_GR.
KEGGsao:SAOUHSC_01364.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0287.
HOGENOMHBG544990.
OMAQRAIRWG.

Enzyme and pathway databases

BioCycSAUR93061:SAOUHSC_01364-MONOMER.

Family and domain databases

InterProIPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PANTHERPTHR21363. Prephen_DH. 1 hit.
PfamPF02153. PDH. 1 hit.
[Graphical view]
PROSITEPS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRA_STAA8
AccessionPrimary (citable) accession number: Q2FYS1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 21, 2006
Last modified: January 19, 2010
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents