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Q2FYS1

- TYRA_STAA8

UniProt

Q2FYS1 - TYRA_STAA8

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Protein

Prephenate dehydrogenase

Gene

tyrA

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi3 – 3331NADSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. prephenate dehydrogenase (NADP+) activity Source: InterPro
  3. prephenate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. tyrosine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-1305-MONOMER.
UniPathwayiUPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:SAOUHSC_01364
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000008816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Prephenate dehydrogenasePRO_0000282661Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01364.

Structurei

3D structure databases

ProteinModelPortaliQ2FYS1.
SMRiQ2FYS1. Positions 3-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 291290Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
BLAST
Domaini296 – 36368ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ACT domain.PROSITE-ProRule annotation
Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0287.
HOGENOMiHOG000043494.
KOiK04517.
OMAiLQITFKN.
OrthoDBiEOG6B8XMB.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF02153. PDH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2FYS1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTVLFVGLG LIGGSLASNI KYHNPNTNII AYDADISQLD KAKSIGIINE
60 70 80 90 100
KCLNYSEAIK KADVIIYATP VAITNKYLSE LIDMPTKPGV IVSDTGSTKA
110 120 130 140 150
MIQQHECNLL KHNIHLVSGH PMAGSHKSGV LNAKKHLFEN AYYILVYNEP
160 170 180 190 200
RNEQAANTLK ELLSPTLAKF IVTTAEEHDY VTSVVSHLPH IVASSLVHVS
210 220 230 240 250
QKNGQEHHLV NKLAAGGFRD ITRIASSNAQ MWKDITLSNK TYILEMIRQL
260 270 280 290 300
KSQFQDLERL IESNDSEKLL SFFAQAKSYR DALPAKQLGG LNTAYDLYVD
310 320 330 340 350
IPDESGMISK VTYILSLHNI SISNLRILEV REDIYGALKI SFKNPTDRER
360
GMQALSDFDC YIQ
Length:363
Mass (Da):40,407
Last modified:March 21, 2006 - v1
Checksum:i07DEF8CC0AB6293E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000253 Genomic DNA. Translation: ABD30459.1.
RefSeqiYP_499891.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD30459; ABD30459; SAOUHSC_01364.
GeneIDi3920069.
KEGGisao:SAOUHSC_01364.
PATRICi19580177. VBIStaAur99865_1248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000253 Genomic DNA. Translation: ABD30459.1 .
RefSeqi YP_499891.1. NC_007795.1.

3D structure databases

ProteinModelPortali Q2FYS1.
SMRi Q2FYS1. Positions 3-283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93061.SAOUHSC_01364.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD30459 ; ABD30459 ; SAOUHSC_01364 .
GeneIDi 3920069.
KEGGi sao:SAOUHSC_01364.
PATRICi 19580177. VBIStaAur99865_1248.

Phylogenomic databases

eggNOGi COG0287.
HOGENOMi HOG000043494.
KOi K04517.
OMAi LQITFKN.
OrthoDBi EOG6B8XMB.

Enzyme and pathway databases

UniPathwayi UPA00122 ; UER00961 .
BioCyci SAUR93061:GIWJ-1305-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view ]
Pfami PF02153. PDH. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Staphylococcus aureus NCTC 8325 genome."
    Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
    (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 8325.

Entry informationi

Entry nameiTYRA_STAA8
AccessioniPrimary (citable) accession number: Q2FYS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 21, 2006
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3