Reviewed, UniProtKB/Swiss-Prot Q2FYJ3 (THD2_STAA8)

Names and origin

Protein names

Recommended name:
    Threonine dehydratase catabolic
    EC=4.3.1.19
Alternative name(s):
    Threonine deaminase

Gene names

Name:	tdcB
Ordered Locus Names:	SAOUHSC_01451

Organism

Staphylococcus aureus (strain NCTC 8325) [Complete proteome] [HAMAP]

Taxonomic identifier

93061 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase By similarity.
Catalytic activity	L-threonine = 2-oxobutanoate + NH3.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 1/4.
Sequence similarities	Belongs to the serine/threonine dehydratase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	L-threonine ammonia-lyase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Threonine dehydratase catabolic		PRO_0000287333
Amino acid modifications
	Modified residue	64	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2FYJ3-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: A69CB839024C9C5F	FASTA	346	37,306
	10 20 30 40 50 60 MTTNTVTLQT AHIVSLGDIE EAKASIKPFI RRTPLIKSMY LSQSITKGNV FLKLENMQFT 70 80 90 100 110 120 GSFKFRGASN KINHLTDEQK EKGIIAASAG NHAQGVALTA KLLGIDATIV MPETAPQAKQ 130 140 150 160 170 180 QATKGYGAKV ILKGKNFNET RLYMEELAKE NGMTIVHPYD DKFVMAGQGT IGLEILDDIW 190 200 210 220 230 240 NVNTVIVPVG GGGLIAGIAT ALKSFNPSIH IIGVQSENVH GMAESFYKRD LTEHRVDSTI 250 260 270 280 290 300 ADGCDVKVPG EQTYEVVKHL VDEFILVTEE EIEHAMKDLM QRAKIITEGA GALPTAAILS 310 320 330 340 GKINNKWLED KNVVALVSGG NVDLTRVSGV IEHGLNIADT SKGVVG

References

[1]	"The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000253 Genomic DNA. Translation: ABD30539.1.
RefSeq	YP_499972.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3920228.
GenomeReviews	Gene locus SAOUHSC_01451 in contig CP000253_GR.
KEGG	sao:SAOUHSC_01451.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2FYJ3.
OMA	Q2FYJ3. IRGALNF.
Enzyme and pathway databases
BioCyc	SAUR93061:SAOUHSC_01451-MON.
Family and domain databases
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. IPR005789. Thr_deHydtase_2. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
TIGRFAMs	TIGR01127. ilvA_1Cterm. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THD2_STAA8

Accession

Primary (citable) accession number: Q2FYJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	March 21, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)