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Protein

Sensor protein SrrB

Gene

srrB

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system SrrA/SrrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates SrrA (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein SrrB (EC:2.7.13.3)
Alternative name(s):
Staphylococcal respiratory response protein B
Gene namesi
Name:srrB
Ordered Locus Names:SAOUHSC_01585
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 174ExtracellularSequence analysisAdd BLAST142
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 583CytoplasmicSequence analysisAdd BLAST388

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002900721 – 583Sensor protein SrrBAdd BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei369Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01585.

Structurei

3D structure databases

ProteinModelPortaliQ2FY80.
SMRiQ2FY80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 249HAMPPROSITE-ProRule annotationAdd BLAST53
Domaini366 – 583Histidine kinasePROSITE-ProRule annotationAdd BLAST218

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000223176.
KOiK07651.
OMAiAFNQMGR.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
cd00082. HisKA. 1 hit.
Gene3Di3.30.565.10. 1 hit.
InterProiView protein in InterPro
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
PfamiView protein in Pfam
PF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiView protein in SMART
SM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiView protein in PROSITE
PS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2FY80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSRLNSVVI KLWLTIILIV TTVLILLSIA LITFMQYYFT QETENAIRED
60 70 80 90 100
ARRISSLVEQ SHNKEEAIKY SQTLIENPGG LMIINNKHRQ STASLSNIKK
110 120 130 140 150
QMLNEVVNND HFDDVFDKGK SVTRNVTIKE KGSSQTYILL GYPTKAQKNS
160 170 180 190 200
HSKYSGVFIY KDLKSIEDTN NAITIITIIT AVIFLTITTV FAFFLSSRIT
210 220 230 240 250
KPLRRLRDQA TRVSEGDYSY KPSVTTKDEI GQLSQAFNQM STEIEEHVDA
260 270 280 290 300
LSTSKNIRDS LINSMVEGVL GINESRQIIL SNKMANDIMD NIDEDAKAFL
310 320 330 340 350
LRQIEDTFKS KQTEMRDLEM NARFFVVTTS YIDKIEQGGK SGVVVTVRDM
360 370 380 390 400
TNEHNLDQMK KDFIANVSHE LRTPISLLQG YTESIVDGIV TEPDEIKESL
410 420 430 440 450
AIVLDESKRL NRLVNELLNV ARMDAEGLSV NKEVQPIAAL LDKMKIKYRQ
460 470 480 490 500
QADDLGLNMT FNYCKKRVWS YDMDRMDQVL TNLIDNASRY TKPGDEIAIT
510 520 530 540 550
CDENESEDIL YIKDTGTGIA PEHLQQVFDR FYKVDAARTR GKQGTGLGLF
560 570 580
ICKMIIEEHG GSIDVKSELG KGTTFIIKLP KPE
Length:583
Mass (Da):66,076
Last modified:March 21, 2006 - v1
Checksum:i7305F6883B016640
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti332I → V in AAP35032 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY197750 Genomic DNA. Translation: AAP35032.1.
CP000253 Genomic DNA. Translation: ABD30664.1.
RefSeqiWP_000987769.1. NC_007795.1.
YP_500100.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD30664; ABD30664; SAOUHSC_01585.
GeneIDi3920001.
KEGGisao:SAOUHSC_01585.
PATRICifig|93061.5.peg.1442.

Similar proteinsi

Entry informationi

Entry nameiSRRB_STAA8
AccessioniPrimary (citable) accession number: Q2FY80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 21, 2006
Last modified: September 27, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome