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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-1548-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:SAOUHSC_01620
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Exodeoxyribonuclease 7 large subunitPRO_0000273696Add
BLAST

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01620.

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229265.
KOiK03601.
OMAiCINALMQ.
OrthoDBiEOG64R65J.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2FY46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDYLSVSAL TKYIKYKFDQ DPHLQSVLIK GELSNFKKHS SGHLYFNVKD
60 70 80 90 100
KESVISAMMF KGSASKLNFE PKEGDEVLLE ARVSVFERRG NYQIYVNKMQ
110 120 130 140 150
LDGIGNLYQK LEALKKKLTE EGCFDKANKK SIPKFPKKIA VLTASTGAAI
160 170 180 190 200
RDIHSTINSR FPLAEQIQIS TLVQGEKAKD DIIEKIEYAD SLGVDTIIVG
210 220 230 240 250
RGGGSIEDLW NFNEEAVVRA IYNCKTPIIS AVGHETDFTL SDFAADIRAA
260 270 280 290 300
TPTQAAVIAT PDQYELLQQI QQYQFTLTRF IKKHLEQQRK HVEHLSSYYK
310 320 330 340 350
FKQPTLLYDQ QIQRRDDLEK RLKQQIQATF EQQRHRLMLL QQRYNLKALL
360 370 380 390 400
SSVNQEQQNN LQLTNQLVKL LNSKILSYKN DLKNKVENLN NLSPTNTMLR
410 420 430 440
GYAIVNKKDE VITSTKDLTE NDQLTLTMKD GLVDAKVTKV RCNND
Length:445
Mass (Da):50,894
Last modified:March 21, 2006 - v1
Checksum:i172C12F9B18EA4EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD30698.1.
RefSeqiWP_001286928.1. NC_007795.1.
YP_500134.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD30698; ABD30698; SAOUHSC_01620.
GeneIDi3919958.
KEGGisao:SAOUHSC_01620.
PATRICi19580629. VBIStaAur99865_1474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD30698.1.
RefSeqiWP_001286928.1. NC_007795.1.
YP_500134.1. NC_007795.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01620.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD30698; ABD30698; SAOUHSC_01620.
GeneIDi3919958.
KEGGisao:SAOUHSC_01620.
PATRICi19580629. VBIStaAur99865_1474.

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229265.
KOiK03601.
OMAiCINALMQ.
OrthoDBiEOG64R65J.

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-1548-MONOMER.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The Staphylococcus aureus NCTC 8325 genome."
    Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
    (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 8325.

Entry informationi

Entry nameiEX7L_STAA8
AccessioniPrimary (citable) accession number: Q2FY46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 21, 2006
Last modified: March 16, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.