Q2FXY1 (AROE_STAA8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	SAOUHSC_01699

Organism

Staphylococcus aureus (strain NCTC 8325)

Taxonomic identifier

93061 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021340
Regions
	Nucleotide binding	124 – 128	5	NADP By similarity
Sites
	Active site	64	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2FXY1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 700864CB11686B89	FASTA	268	29,879
	10 20 30 40 50 60 MKFAVIGNPI SHSLSPVMHR ANFNSLGLDD TYEALNIPIE DFHLIKEIIS KKELEGFNIT 70 80 90 100 110 120 IPHKERIIPY LDYVDEQAIN AGAVNTVLIK DGKWIGYNTD GIGYVKGLHS VYPDLENAYI 130 140 150 160 170 180 LILGAGGASK GIAYELAKFV KPKLTVANRT MARFESWNLN INQISLADAE KYLAEFDIVI 190 200 210 220 230 240 NTTPAGMAGN NESIINLKHL SPNTLMSDIV YIPYKTPILE EAERKGNHIY NGLDMFVYQG 250 260 AESFKIWTNK DADINSMKTA VLQQLKGE

References

[1]	"The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 8325.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000253 Genomic DNA. Translation: ABD30773.1.
RefSeq	YP_500209.1. NC_007795.1.
3D structure databases
ProteinModelPortal	Q2FXY1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2FXY1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000028231; EBSTAP00000027182; EBSTAG00000028230.
GeneID	3921811.
GenomeReviews	Gene locus SAOUHSC_01699 in contig CP000253_GR.
KEGG	sao:SAOUHSC_01699.
PATRIC	19580775. VBIStaAur99865_1548.
Phylogenomic databases
eggNOG	COG0169.
GeneTree	EBGT00050000025479.
HOGENOM	HBG553408.
OMA	TLFMKKG.
PhylomeDB	Q2FXY1.
ProtClustDB	CLSK885454.
Enzyme and pathway databases
BioCyc	SAUR93061:SAOUHSC_01699-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_STAA8

Accession

Primary (citable) accession number: Q2FXY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program