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Q2FXR4

- GSA1_STAA8

UniProt

Q2FXR4 - GSA1_STAA8

Protein

Glutamate-1-semialdehyde 2,1-aminomutase 1

Gene

hemL1

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSAUR93061:GIWJ-1690-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutase 1 (EC:5.4.3.8)
    Short name:
    GSA 1
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferase 1
    Short name:
    GSA-AT 1
    Gene namesi
    Name:hemL1
    Synonyms:hemL
    Ordered Locus Names:SAOUHSC_01771
    OrganismiStaphylococcus aureus (strain NCTC 8325)
    Taxonomic identifieri93061 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000008816: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Glutamate-1-semialdehyde 2,1-aminomutase 1PRO_0000247015Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei267 – 2671N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi93061.SAOUHSC_01771.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2FXR4.
    SMRiQ2FXR4. Positions 3-428.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiRAIKPYP.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2FXR4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRYTKSEEAM KVAETLMPGG VNSPVRAFKS VDTPAIFMDH GKGSKIYDID    50
    GNEYIDYVLS WGPLILGHRD PQVISHLHEA IDKGTSFGAS TLLENKLAQL 100
    VIDRVPSIEK VRMVSSGTEA TLDTLRLARG YTGRNKIVKF EGCYHGHSDS 150
    LLIKAGSGVA TLGLPDSPGV PEGIAKNTIT VPYNDLDALK IAFEKFGNDI 200
    AGVIVEPVAG NMGVVPPIEG FLQGLRDITT EYGALLIFDE VMTGFRVGYH 250
    CAQGYFGVTP DLTCLGKVIG GGLPVGAFGG KKEIMDHIAP LGNIYQAGTL 300
    SGNPLAMTSG YETLSQLTPE TYEYFNMLGD ILEDGLKRVF AKHNVPITVN 350
    RAGSMIGYFL NEGPVTNFEQ ANKSDLKLFA EMYREMAKEG VFLPPSQFEG 400
    TFLSTAHTKE DIEKTIQAFD TALSRIVK 428
    Length:428
    Mass (Da):46,388
    Last modified:March 21, 2006 - v1
    Checksum:i88F0566FC5A26D49
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti370 – 3701Q → T in AAC45836. (PubMed:9358061)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89396 Genomic DNA. Translation: AAC45836.1.
    CP000253 Genomic DNA. Translation: ABD30840.1.
    RefSeqiYP_500276.1. NC_007795.1.

    Genome annotation databases

    EnsemblBacteriaiABD30840; ABD30840; SAOUHSC_01771.
    GeneIDi3919689.
    KEGGisao:SAOUHSC_01771.
    PATRICi19580909. VBIStaAur99865_1615.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89396 Genomic DNA. Translation: AAC45836.1 .
    CP000253 Genomic DNA. Translation: ABD30840.1 .
    RefSeqi YP_500276.1. NC_007795.1.

    3D structure databases

    ProteinModelPortali Q2FXR4.
    SMRi Q2FXR4. Positions 3-428.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93061.SAOUHSC_01771.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD30840 ; ABD30840 ; SAOUHSC_01771 .
    GeneIDi 3919689.
    KEGGi sao:SAOUHSC_01771.
    PATRICi 19580909. VBIStaAur99865_1615.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi RAIKPYP.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci SAUR93061:GIWJ-1690-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of the Staphylococcus aureus hemCDBL gene cluster coding for early steps in heme biosynthesis."
      Kafala B., Sasarman A.
      Gene 199:231-239(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The Staphylococcus aureus NCTC 8325 genome."
      Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
      (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 8325.

    Entry informationi

    Entry nameiGSA1_STAA8
    AccessioniPrimary (citable) accession number: Q2FXR4
    Secondary accession number(s): O34092, Q9RL91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3