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Q2FXI2

- TRMB_STAA8

UniProt

Q2FXI2 - TRMB_STAA8

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, SAOUHSC_01865
Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431S-adenosyl-L-methionine By similarity
Binding sitei68 – 681S-adenosyl-L-methionine By similarity
Binding sitei95 – 951S-adenosyl-L-methionine By similarity
Active sitei117 – 1171 By similarity
Binding sitei117 – 1171S-adenosyl-L-methionine By similarity
Binding sitei121 – 1211Substrate By similarity
Binding sitei153 – 1531Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-1782-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:SAOUHSC_01865
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000008816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000288232Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01865.

Structurei

3D structure databases

ProteinModelPortaliQ2FXI2.
SMRiQ2FXI2. Positions 9-210.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni190 – 1934Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiDNVMTEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2FXI2-1 [UniParc]FASTAAdd to Basket

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MRVRYKPWAE DYLKDHPELV DMDGQHAGKM TEWFDKTQPI HIEIGSGMGQ    50
FITTLAAQNP HINYISMERE KSIVYKVLDK VKEMGLTNLK IICNDAIELN 100
EYFKDGEVSR IYLNFSDPWP KNRHAKRRLT YHTFLALYQQ ILNDEGDLHF 150
KTDNRGLFAY SLESMSQFGM YFTKINLNLH QEDDGSNILT EYEKKFSDKG 200
SRIYRMEAKF HSQK 214
Length:214
Mass (Da):25,276
Last modified:March 21, 2006 - v1
Checksum:i92987FE746A9DDD4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000253 Genomic DNA. Translation: ABD30930.1.
RefSeqiYP_500368.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD30930; ABD30930; SAOUHSC_01865.
GeneIDi3921754.
KEGGisao:SAOUHSC_01865.
PATRICi19581073. VBIStaAur99865_1697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000253 Genomic DNA. Translation: ABD30930.1 .
RefSeqi YP_500368.1. NC_007795.1.

3D structure databases

ProteinModelPortali Q2FXI2.
SMRi Q2FXI2. Positions 9-210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93061.SAOUHSC_01865.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD30930 ; ABD30930 ; SAOUHSC_01865 .
GeneIDi 3921754.
KEGGi sao:SAOUHSC_01865.
PATRICi 19581073. VBIStaAur99865_1697.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi DNVMTEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci SAUR93061:GIWJ-1782-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Staphylococcus aureus NCTC 8325 genome."
    Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
    (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 8325.

Entry informationi

Entry nameiTRMB_STAA8
AccessioniPrimary (citable) accession number: Q2FXI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 21, 2006
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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