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Q2FXF5 (ARSC_STAA8) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein ArsC
Alternative name(s):
Arsenate reductase
EC=1.20.4.-
Arsenical pump modifier
Low molecular weight protein-tyrosine-phosphatase
EC=3.1.3.48
Gene names
Name:arsC
Ordered Locus Names:SAOUHSC_01894
OrganismStaphylococcus aureus (strain NCTC 8325) [Reference proteome] [HAMAP]
Taxonomic identifier93061 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances By similarity. HAMAP-Rule MF_01624

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. HAMAP-Rule MF_01624

Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O. HAMAP-Rule MF_01624

Subunit structure

Monomer By similarity. HAMAP-Rule MF_01624

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 131131Protein ArsC HAMAP-Rule MF_01624
PRO_0000290356

Sites

Active site101Nucleophile; for reductase activity and phosphatase activity By similarity
Active site821Nucleophile; for reductase activity By similarity
Active site891Nucleophile; for reductase activity By similarity

Amino acid modifications

Disulfide bond10 ↔ 82Redox-active; alternate By similarity
Disulfide bond82 ↔ 89Redox-active; alternate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2FXF5 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 9B6AA5A854D66C89

FASTA13114,687
        10         20         30         40         50         60 
MTKKTIYFIC TGNSCRSQMA EGWAKQILAD DWNVYSAGIE THGVNPKAIE AMKEVGIDIS 

        70         80         90        100        110        120 
NHTSDLIDNN IIKNSNLVVT LCSDADVNCP SLPTNVKKEH WGFDDPAGKP WSEFQRVRDE 

       130 
IKIAIENFKS R 

« Hide

References

« Hide 'large scale' references
[1]Cramton S.E., Richard C., Oberfeld B., Pfitzner U., Gotz F.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Tibor L., Cramton S.E., Goetz F., Hunt T.K.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The Staphylococcus aureus NCTC8325 genome."
Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 8325.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF422190 Genomic DNA. Translation: AAN32731.1.
AY194063 Genomic DNA. Translation: AAP32342.1.
CP000253 Genomic DNA. Translation: ABD30957.1.
RefSeqYP_500395.1. NC_007795.1.

3D structure databases

ProteinModelPortalQ2FXF5.
SMRQ2FXF5. Positions 3-131.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING93061.SAOUHSC_01894.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD30957; ABD30957; SAOUHSC_01894.
GeneID3920841.
KEGGsao:SAOUHSC_01894.
PATRIC19581125. VBIStaAur99865_1723.

Phylogenomic databases

eggNOGCOG0394.
HOGENOMHOG000273093.
KOK03741.
OMAEMRIVIT.
OrthoDBEOG6JDWJC.
ProtClustDBPRK13530.

Enzyme and pathway databases

BioCycSAUR93061:GIWJ-1809-MONOMER.

Family and domain databases

HAMAPMF_01624. Arsenate_reduct.
InterProIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. PTHR11717. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
TIGRFAMsTIGR02691. arsC_pI258_fam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARSC_STAA8
AccessionPrimary (citable) accession number: Q2FXF5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 21, 2006
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families