Reviewed,
UniProtKB/Swiss-Prot Q2FXF5 (ARSC_STAA8)
Last modified
February 9, 2010.
Version 27.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein arsC Alternative name(s): Arsenate reductase EC=1.20.4.- Arsenical pump modifier Low molecular weight protein-tyrosine-phosphatase EC=3.1.3.48 | ||||
| Gene names |
| ||||
| Organism | Staphylococcus aureus (strain NCTC 8325) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 93061 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Staphylococcus |
Protein attributes
| Sequence length | 131 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances By similarity. HAMAP MF_01624 |
| Catalytic activity | Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. HAMAP MF_01624 Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O. HAMAP MF_01624 |
| Subunit structure | Monomer By similarity. HAMAP MF_01624 |
| Sequence similarities | Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Arsenical resistance |
| Domain | Redox-active center |
| Molecular function | Hydrolase Oxidoreductase |
| PTM | Disulfide bond |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid dephosphorylationInferred from electronic annotation. Source: InterPro response to arsenicInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | arsenate reductase (thioredoxin) activity Inferred from electronic annotation. Source: HAMAP protein tyrosine phosphatase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 131 | 131 | Protein arsC HAMAP MF_01624 | PRO_0000290356 | |||||||
Sites | |||||||||||
| Active site | 10 | 1 | Nucleophile; for reductase activity and phosphatase activity By similarity | ||||||||
| Active site | 82 | 1 | Nucleophile; for reductase activity By similarity | ||||||||
| Active site | 89 | 1 | Nucleophile; for reductase activity By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 10 ↔ 82 | Redox-active; alternate By similarity | |||||||||
| Disulfide bond | 82 ↔ 89 | Redox-active; alternate By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Cramton S.E., Richard C., Oberfeld B., Pfitzner U., Gotz F. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | Tibor L., Cramton S.E., Goetz F., Hunt T.K. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF422190 Genomic DNA. Translation: AAN32731.1. AY194063 Genomic DNA. Translation: AAP32342.1. CP000253 Genomic DNA. Translation: ABD30957.1. |
| RefSeq | YP_500395.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1ZGG based on UniProtKB P39155. |
| SMR | Q2FXF5. Positions 3-131. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q2FXF5. |
Genome annotation databases | |
| GeneID | 3920841. |
| GenomeReviews | Gene locus SAOUHSC_01894 in contig CP000253_GR. |
| KEGG | sao:SAOUHSC_01894. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0394. |
| HOGENOM | HBG730979. |
| OMA | EMRIVIT. |
Enzyme and pathway databases | |
| BioCyc | SAUR93061:SAOUHSC_01894-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01624. Arsenate_reduct. [Tree] |
| InterPro | IPR014064. Arsenate_reductase_StaphA. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view] |
| PANTHER | PTHR11717. Low_mwt_PTPase. 1 hit. |
| Pfam | PF01451. LMWPc. 1 hit. [Graphical view] |
| SMART | SM00226. LMWPc. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR02691. arsC_pI258_fam. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ARSC_STAA8 | ||||||||
| Accession | Primary (citable) accession number: Q2FXF5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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