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Q2FXC2 (SPLA_STAA8) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine protease SplA

EC=3.4.21.-
Gene names
Name:splA
Ordered Locus Names:SAOUHSC_01942
OrganismStaphylococcus aureus (strain NCTC 8325) [Reference proteome] [HAMAP]
Taxonomic identifier93061 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted Ref.1.

Developmental stage

Maximally expressed during early stationary phase. Ref.1

Induction

Positively regulated by agr (accessory gene regulator). Ref.1

Sequence similarities

Belongs to the peptidase S1B family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Ref.1
Chain36 – 235200Serine protease SplA
PRO_0000359533

Sites

Active site741Charge relay system By similarity
Active site1131Charge relay system By similarity
Active site1891Charge relay system By similarity

Secondary structure

........................................ 235
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q2FXC2 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: DBC6B23C6648BCF9

FASTA23525,549
        10         20         30         40         50         60 
MNKNVMVKGL TALTILTSLG FAENISNQPH SIAKAEKNVK EITDATKEPY NSVVAFVGGT 

        70         80         90        100        110        120 
GVVVGKNTIV TNKHIAKSND IFKNRVSAHH SSKGKGGGNY DVKDIVEYPG KEDLAIVHVH 

       130        140        150        160        170        180 
ETSTEGLNFN KNVSYTKFAD GAKVKDRISV IGYPKGAQTK YKMFESTGTI NHISGTFMEF 

       190        200        210        220        230 
DAYAQPGNSG SPVLNSKHEL IGILYAGSGK DESEKNFGVY FTPQLKEFIQ NNIEK 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization of a novel Staphylococcus aureus serine protease operon."
Reed S.B., Wesson C.A., Liou L.E., Trumble W.R., Schlievert P.M., Bohach G.A., Bayles K.W.
Infect. Immun. 69:1521-1527(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 36-50, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INDUCTION.
[2]"The Staphylococcus aureus NCTC8325 genome."
Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 8325.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF271715 Genomic DNA. Translation: AAF97925.1.
CP000253 Genomic DNA. Translation: ABD31004.1.
RefSeqYP_500442.1. NC_007795.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2W7SX-ray1.80A/B/C/D36-235[»]
2W7UX-ray2.43A/B/C/D36-235[»]
3UFAX-ray1.80A/B36-235[»]
4MVNX-ray1.70A/B/C/D36-235[»]
ProteinModelPortalQ2FXC2.
SMRQ2FXC2. Positions 36-235.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING93061.SAOUHSC_01942.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD31004; ABD31004; SAOUHSC_01942.
GeneID3921025.
KEGGsao:SAOUHSC_01942.
PATRIC19581213. VBIStaAur99865_1767.

Phylogenomic databases

eggNOGCOG3591.
HOGENOMHOG000107379.
KOK01318.
OMATINHING.
OrthoDBEOG6423F5.
ProtClustDBCLSK885576.

Enzyme and pathway databases

BioCycSAUR93061:GIWJ-1856-MONOMER.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR008256. Peptidase_S1B.
IPR008353. Peptidase_S1B_tx.
IPR009003. Trypsin-like_Pept_dom.
IPR028301. V8_his_AS.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR01774. EXFOLTOXIN.
PR00839. V8PROTEASE.
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS00672. V8_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ2FXC2.

Entry information

Entry nameSPLA_STAA8
AccessionPrimary (citable) accession number: Q2FXC2
Secondary accession number(s): Q9KH51
Entry history
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: March 21, 2006
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references