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Q2FXC2

- SPLA_STAA8

UniProt

Q2FXC2 - SPLA_STAA8

Protein

Serine protease SplA

Gene

splA

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei74 – 741Charge relay systemBy similarity
    Active sitei113 – 1131Charge relay systemBy similarity
    Active sitei189 – 1891Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BioCyciSAUR93061:GIWJ-1856-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine protease SplA (EC:3.4.21.-)
    Gene namesi
    Name:splA
    Ordered Locus Names:SAOUHSC_01942
    OrganismiStaphylococcus aureus (strain NCTC 8325)
    Taxonomic identifieri93061 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000008816: Chromosome

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 35351 PublicationAdd
    BLAST
    Chaini36 – 235200Serine protease SplAPRO_0000359533Add
    BLAST

    Expressioni

    Developmental stagei

    Maximally expressed during early stationary phase.1 Publication

    Inductioni

    Positively regulated by agr (accessory gene regulator).1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi93061.SAOUHSC_01942.

    Structurei

    Secondary structure

    1
    235
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi39 – 435
    Helixi50 – 523
    Beta strandi53 – 564
    Beta strandi59 – 657
    Beta strandi68 – 714
    Helixi73 – 8210
    Beta strandi86 – 894
    Beta strandi92 – 943
    Beta strandi102 – 1076
    Beta strandi109 – 1135
    Beta strandi115 – 1195
    Helixi129 – 1324
    Beta strandi147 – 1526
    Helixi156 – 1583
    Beta strandi163 – 17412
    Beta strandi177 – 1804
    Beta strandi192 – 1943
    Beta strandi200 – 2078
    Beta strandi215 – 2206
    Helixi223 – 2319

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2W7SX-ray1.80A/B/C/D36-235[»]
    2W7UX-ray2.43A/B/C/D36-235[»]
    3UFAX-ray1.80A/B36-235[»]
    4MVNX-ray1.70A/B/C/D36-235[»]
    ProteinModelPortaliQ2FXC2.
    SMRiQ2FXC2. Positions 36-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ2FXC2.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S1B family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3591.
    HOGENOMiHOG000107379.
    KOiK01318.
    OMAiTINHING.
    OrthoDBiEOG6423F5.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR008256. Peptidase_S1B.
    IPR008353. Peptidase_S1B_tx.
    IPR009003. Trypsin-like_Pept_dom.
    IPR028301. V8_his_AS.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR01774. EXFOLTOXIN.
    PR00839. V8PROTEASE.
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS00672. V8_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2FXC2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKNVMVKGL TALTILTSLG FAENISNQPH SIAKAEKNVK EITDATKEPY    50
    NSVVAFVGGT GVVVGKNTIV TNKHIAKSND IFKNRVSAHH SSKGKGGGNY 100
    DVKDIVEYPG KEDLAIVHVH ETSTEGLNFN KNVSYTKFAD GAKVKDRISV 150
    IGYPKGAQTK YKMFESTGTI NHISGTFMEF DAYAQPGNSG SPVLNSKHEL 200
    IGILYAGSGK DESEKNFGVY FTPQLKEFIQ NNIEK 235
    Length:235
    Mass (Da):25,549
    Last modified:March 21, 2006 - v1
    Checksum:iDBC6B23C6648BCF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF271715 Genomic DNA. Translation: AAF97925.1.
    CP000253 Genomic DNA. Translation: ABD31004.1.
    RefSeqiWP_001039435.1. NC_007795.1.
    YP_500442.1. NC_007795.1.

    Genome annotation databases

    EnsemblBacteriaiABD31004; ABD31004; SAOUHSC_01942.
    GeneIDi3921025.
    KEGGisao:SAOUHSC_01942.
    PATRICi19581213. VBIStaAur99865_1767.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF271715 Genomic DNA. Translation: AAF97925.1 .
    CP000253 Genomic DNA. Translation: ABD31004.1 .
    RefSeqi WP_001039435.1. NC_007795.1.
    YP_500442.1. NC_007795.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2W7S X-ray 1.80 A/B/C/D 36-235 [» ]
    2W7U X-ray 2.43 A/B/C/D 36-235 [» ]
    3UFA X-ray 1.80 A/B 36-235 [» ]
    4MVN X-ray 1.70 A/B/C/D 36-235 [» ]
    ProteinModelPortali Q2FXC2.
    SMRi Q2FXC2. Positions 36-235.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93061.SAOUHSC_01942.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD31004 ; ABD31004 ; SAOUHSC_01942 .
    GeneIDi 3921025.
    KEGGi sao:SAOUHSC_01942.
    PATRICi 19581213. VBIStaAur99865_1767.

    Phylogenomic databases

    eggNOGi COG3591.
    HOGENOMi HOG000107379.
    KOi K01318.
    OMAi TINHING.
    OrthoDBi EOG6423F5.

    Enzyme and pathway databases

    BioCyci SAUR93061:GIWJ-1856-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q2FXC2.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR008256. Peptidase_S1B.
    IPR008353. Peptidase_S1B_tx.
    IPR009003. Trypsin-like_Pept_dom.
    IPR028301. V8_his_AS.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR01774. EXFOLTOXIN.
    PR00839. V8PROTEASE.
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS00672. V8_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a novel Staphylococcus aureus serine protease operon."
      Reed S.B., Wesson C.A., Liou L.E., Trumble W.R., Schlievert P.M., Bohach G.A., Bayles K.W.
      Infect. Immun. 69:1521-1527(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 36-50, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INDUCTION.
    2. "The Staphylococcus aureus NCTC 8325 genome."
      Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
      (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 8325.

    Entry informationi

    Entry nameiSPLA_STAA8
    AccessioniPrimary (citable) accession number: Q2FXC2
    Secondary accession number(s): Q9KH51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3