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Q2FXC2

- SPLA_STAA8

UniProt

Q2FXC2 - SPLA_STAA8

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Protein

Serine protease SplA

Gene

splA

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei74 – 741Charge relay systemBy similarity
Active sitei113 – 1131Charge relay systemBy similarity
Active sitei189 – 1891Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-1856-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease SplA (EC:3.4.21.-)
Gene namesi
Name:splA
Ordered Locus Names:SAOUHSC_01942
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000008816: Chromosome

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 35351 PublicationAdd
BLAST
Chaini36 – 235200Serine protease SplAPRO_0000359533Add
BLAST

Expressioni

Developmental stagei

Maximally expressed during early stationary phase.1 Publication

Inductioni

Positively regulated by agr (accessory gene regulator).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01942.

Structurei

Secondary structure

1
235
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi39 – 435Combined sources
Helixi50 – 523Combined sources
Beta strandi53 – 564Combined sources
Beta strandi59 – 657Combined sources
Beta strandi68 – 714Combined sources
Helixi73 – 8210Combined sources
Beta strandi86 – 894Combined sources
Beta strandi92 – 943Combined sources
Beta strandi102 – 1076Combined sources
Beta strandi109 – 1135Combined sources
Beta strandi115 – 1195Combined sources
Helixi129 – 1324Combined sources
Beta strandi147 – 1526Combined sources
Helixi156 – 1583Combined sources
Beta strandi163 – 17412Combined sources
Beta strandi177 – 1804Combined sources
Beta strandi192 – 1943Combined sources
Beta strandi200 – 2078Combined sources
Beta strandi215 – 2206Combined sources
Helixi223 – 2319Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2W7SX-ray1.80A/B/C/D36-235[»]
2W7UX-ray2.43A/B/C/D36-235[»]
3UFAX-ray1.80A/B36-235[»]
4MVNX-ray1.70A/B/C/D36-235[»]
ProteinModelPortaliQ2FXC2.
SMRiQ2FXC2. Positions 36-235.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ2FXC2.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S1B family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3591.
HOGENOMiHOG000107379.
KOiK01318.
OMAiTINHING.
OrthoDBiEOG6423F5.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR008256. Peptidase_S1B.
IPR008353. Peptidase_S1B_tx.
IPR009003. Trypsin-like_Pept_dom.
IPR028301. V8_his_AS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR01774. EXFOLTOXIN.
PR00839. V8PROTEASE.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00672. V8_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2FXC2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKNVMVKGL TALTILTSLG FAENISNQPH SIAKAEKNVK EITDATKEPY
60 70 80 90 100
NSVVAFVGGT GVVVGKNTIV TNKHIAKSND IFKNRVSAHH SSKGKGGGNY
110 120 130 140 150
DVKDIVEYPG KEDLAIVHVH ETSTEGLNFN KNVSYTKFAD GAKVKDRISV
160 170 180 190 200
IGYPKGAQTK YKMFESTGTI NHISGTFMEF DAYAQPGNSG SPVLNSKHEL
210 220 230
IGILYAGSGK DESEKNFGVY FTPQLKEFIQ NNIEK
Length:235
Mass (Da):25,549
Last modified:March 21, 2006 - v1
Checksum:iDBC6B23C6648BCF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271715 Genomic DNA. Translation: AAF97925.1.
CP000253 Genomic DNA. Translation: ABD31004.1.
RefSeqiWP_001039435.1. NC_007795.1.
YP_500442.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD31004; ABD31004; SAOUHSC_01942.
GeneIDi3921025.
KEGGisao:SAOUHSC_01942.
PATRICi19581213. VBIStaAur99865_1767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271715 Genomic DNA. Translation: AAF97925.1 .
CP000253 Genomic DNA. Translation: ABD31004.1 .
RefSeqi WP_001039435.1. NC_007795.1.
YP_500442.1. NC_007795.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2W7S X-ray 1.80 A/B/C/D 36-235 [» ]
2W7U X-ray 2.43 A/B/C/D 36-235 [» ]
3UFA X-ray 1.80 A/B 36-235 [» ]
4MVN X-ray 1.70 A/B/C/D 36-235 [» ]
ProteinModelPortali Q2FXC2.
SMRi Q2FXC2. Positions 36-235.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93061.SAOUHSC_01942.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD31004 ; ABD31004 ; SAOUHSC_01942 .
GeneIDi 3921025.
KEGGi sao:SAOUHSC_01942.
PATRICi 19581213. VBIStaAur99865_1767.

Phylogenomic databases

eggNOGi COG3591.
HOGENOMi HOG000107379.
KOi K01318.
OMAi TINHING.
OrthoDBi EOG6423F5.

Enzyme and pathway databases

BioCyci SAUR93061:GIWJ-1856-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q2FXC2.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR008256. Peptidase_S1B.
IPR008353. Peptidase_S1B_tx.
IPR009003. Trypsin-like_Pept_dom.
IPR028301. V8_his_AS.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR01774. EXFOLTOXIN.
PR00839. V8PROTEASE.
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS00672. V8_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a novel Staphylococcus aureus serine protease operon."
    Reed S.B., Wesson C.A., Liou L.E., Trumble W.R., Schlievert P.M., Bohach G.A., Bayles K.W.
    Infect. Immun. 69:1521-1527(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 36-50, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INDUCTION.
  2. "The Staphylococcus aureus NCTC 8325 genome."
    Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
    (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 8325.

Entry informationi

Entry nameiSPLA_STAA8
AccessioniPrimary (citable) accession number: Q2FXC2
Secondary accession number(s): Q9KH51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: March 21, 2006
Last modified: November 26, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3