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Q2FXC2

- SPLA_STAA8

UniProt

Q2FXC2 - SPLA_STAA8

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Protein
Serine protease SplA
Gene
splA, SAOUHSC_01942
Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei74 – 741Charge relay system By similarity
Active sitei113 – 1131Charge relay system By similarity
Active sitei189 – 1891Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-1856-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease SplA (EC:3.4.21.-)
Gene namesi
Name:splA
Ordered Locus Names:SAOUHSC_01942
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000008816: Chromosome

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 35351 Publication
Add
BLAST
Chaini36 – 235200Serine protease SplA
PRO_0000359533Add
BLAST

Expressioni

Developmental stagei

Maximally expressed during early stationary phase.1 Publication

Inductioni

Positively regulated by agr (accessory gene regulator).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01942.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi39 – 435
Helixi50 – 523
Beta strandi53 – 564
Beta strandi59 – 657
Beta strandi68 – 714
Helixi73 – 8210
Beta strandi86 – 894
Beta strandi92 – 943
Beta strandi102 – 1076
Beta strandi109 – 1135
Beta strandi115 – 1195
Helixi129 – 1324
Beta strandi147 – 1526
Helixi156 – 1583
Beta strandi163 – 17412
Beta strandi177 – 1804
Beta strandi192 – 1943
Beta strandi200 – 2078
Beta strandi215 – 2206
Helixi223 – 2319

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2W7SX-ray1.80A/B/C/D36-235[»]
2W7UX-ray2.43A/B/C/D36-235[»]
3UFAX-ray1.80A/B36-235[»]
4MVNX-ray1.70A/B/C/D36-235[»]
ProteinModelPortaliQ2FXC2.
SMRiQ2FXC2. Positions 36-235.

Miscellaneous databases

EvolutionaryTraceiQ2FXC2.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S1B family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3591.
HOGENOMiHOG000107379.
KOiK01318.
OMAiTINHING.
OrthoDBiEOG6423F5.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR008256. Peptidase_S1B.
IPR008353. Peptidase_S1B_tx.
IPR009003. Trypsin-like_Pept_dom.
IPR028301. V8_his_AS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR01774. EXFOLTOXIN.
PR00839. V8PROTEASE.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00672. V8_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2FXC2-1 [UniParc]FASTAAdd to Basket

« Hide

MNKNVMVKGL TALTILTSLG FAENISNQPH SIAKAEKNVK EITDATKEPY    50
NSVVAFVGGT GVVVGKNTIV TNKHIAKSND IFKNRVSAHH SSKGKGGGNY 100
DVKDIVEYPG KEDLAIVHVH ETSTEGLNFN KNVSYTKFAD GAKVKDRISV 150
IGYPKGAQTK YKMFESTGTI NHISGTFMEF DAYAQPGNSG SPVLNSKHEL 200
IGILYAGSGK DESEKNFGVY FTPQLKEFIQ NNIEK 235
Length:235
Mass (Da):25,549
Last modified:March 21, 2006 - v1
Checksum:iDBC6B23C6648BCF9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF271715 Genomic DNA. Translation: AAF97925.1.
CP000253 Genomic DNA. Translation: ABD31004.1.
RefSeqiWP_001039435.1. NC_007795.1.
YP_500442.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD31004; ABD31004; SAOUHSC_01942.
GeneIDi3921025.
KEGGisao:SAOUHSC_01942.
PATRICi19581213. VBIStaAur99865_1767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF271715 Genomic DNA. Translation: AAF97925.1 .
CP000253 Genomic DNA. Translation: ABD31004.1 .
RefSeqi WP_001039435.1. NC_007795.1.
YP_500442.1. NC_007795.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2W7S X-ray 1.80 A/B/C/D 36-235 [» ]
2W7U X-ray 2.43 A/B/C/D 36-235 [» ]
3UFA X-ray 1.80 A/B 36-235 [» ]
4MVN X-ray 1.70 A/B/C/D 36-235 [» ]
ProteinModelPortali Q2FXC2.
SMRi Q2FXC2. Positions 36-235.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93061.SAOUHSC_01942.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD31004 ; ABD31004 ; SAOUHSC_01942 .
GeneIDi 3921025.
KEGGi sao:SAOUHSC_01942.
PATRICi 19581213. VBIStaAur99865_1767.

Phylogenomic databases

eggNOGi COG3591.
HOGENOMi HOG000107379.
KOi K01318.
OMAi TINHING.
OrthoDBi EOG6423F5.

Enzyme and pathway databases

BioCyci SAUR93061:GIWJ-1856-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q2FXC2.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR008256. Peptidase_S1B.
IPR008353. Peptidase_S1B_tx.
IPR009003. Trypsin-like_Pept_dom.
IPR028301. V8_his_AS.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR01774. EXFOLTOXIN.
PR00839. V8PROTEASE.
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS00672. V8_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a novel Staphylococcus aureus serine protease operon."
    Reed S.B., Wesson C.A., Liou L.E., Trumble W.R., Schlievert P.M., Bohach G.A., Bayles K.W.
    Infect. Immun. 69:1521-1527(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 36-50, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INDUCTION.
  2. "The Staphylococcus aureus NCTC 8325 genome."
    Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
    (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 8325.

Entry informationi

Entry nameiSPLA_STAA8
AccessioniPrimary (citable) accession number: Q2FXC2
Secondary accession number(s): Q9KH51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: March 21, 2006
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi