Q2FX12 (PTPA_STAA8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low molecular weight protein-tyrosine-phosphatase PtpA
EC=3.1.3.48

Alternative name(s):
Phosphotyrosine phosphatase A
Short name=PTPase A

Gene names

Name:	ptpA
Ordered Locus Names:	SAOUHSC_02095

Organism

Staphylococcus aureus (strain NCTC 8325) [Reference proteome] [HAMAP]

Taxonomic identifier

93061 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Dephosphorylates the phosphotyrosine-containing proteins By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 154	154	Low molecular weight protein-tyrosine-phosphatase PtpA		PRO_0000300664
Sites
	Active site	8	1	Nucleophile By similarity
	Active site	14	1	By similarity
	Active site	120	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2FX12 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 67E81E0B8125B1E8	FASTA	154	17,491
	10 20 30 40 50 60 MVDVAFVCLG NICRSPMAEA IMRQRLKDRN IHDIKVHSRG TGSWNLGEPP HEGTQKILNK 70 80 90 100 110 120 HNIPFDGMIS ELFEATDDFD YIVAMDQSNV DNIKSINPNL KGQLFKLLEF SNMEESDVPD 130 140 150 PYYTNNFEGV YDMVLSSCDN LIDYIVKDAN LKEG

References

[1]	"The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 8325.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000253 Genomic DNA. Translation: ABD31145.1.
RefSeq	YP_500586.1. NC_007795.1.
3D structure databases
HSSP	HSSP built from PDB template 2GI4 based on UniProtKB Q9PN39.
ProteinModelPortal	Q2FX12.
SMR	Q2FX12. Positions 1-152.
ModBase	Search...
Protein-protein interaction databases
STRING	93061.SAOUHSC_02095.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABD31145; ABD31145; SAOUHSC_02095.
GeneID	3921167.
KEGG	sao:SAOUHSC_02095.
PATRIC	19581557. VBIStaAur99865_1900.
Phylogenomic databases
eggNOG	COG0394.
HOGENOM	HOG000273094.
KO	K01104.
OMA	SAENIMN.
ProtClustDB	CLSK885622.
Enzyme and pathway databases
BioCyc	SAUR93061:GIWJ-2039-MONOMER.
Family and domain databases
InterPro	IPR023485. Ptyr_pPase_SF. IPR000106. Tyr_phospatase/Ars_reductase. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
PANTHER	PTHR11717. PTHR11717. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
PRINTS	PR00719. LMWPTPASE.
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
SUPFAM	SSF52788. Tyr_Pase_low_mol_wt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PTPA_STAA8

Accession

Primary (citable) accession number: Q2FX12

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	March 21, 2006
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program