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Q2FWZ8

- FTN_STAA8

UniProt

Q2FWZ8 - FTN_STAA8

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Protein
Ferritin
Gene
ftnA, SAOUHSC_02108
Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Iron-storage protein By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Iron 1 By similarity
Metal bindingi50 – 501Iron 1 By similarity
Metal bindingi50 – 501Iron 2 By similarity
Metal bindingi53 – 531Iron 1 By similarity
Metal bindingi94 – 941Iron 2 By similarity
Metal bindingi127 – 1271Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-2053-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin (EC:1.16.3.1)
Gene namesi
Name:ftnA
Ordered Locus Names:SAOUHSC_02108
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000008816: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 166165Ferritin
PRO_0000295894Add
BLAST

Expressioni

Inductioni

Induced by iron. Repressed by PerR. Negatively regulated by Fur. In addition, is regulated in a PerR-independent way under metal-depleted conditions.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02108.

Structurei

3D structure databases

ProteinModelPortaliQ2FWZ8.
SMRiQ2FWZ8. Positions 1-161.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 145144Ferritin-like diiron
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1528.
HOGENOMiHOG000223382.
KOiK02217.
OMAiFANFYIQ.
OrthoDBiEOG6G4W12.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2FWZ8-1 [UniParc]FASTAAdd to Basket

« Hide

MLSKNLLEAL NDQMNHEYFA AHAYMAMAAY CDKESYEGFA NFFIQQAKEE    50
RFHGQKIYNY INDRGAHAEF RAVSAPKIDF SSILETFKDS LSQEQEVTRR 100
FYNLSEIARQ DKDYATISFL NWFLDEQVEE ESMFETHINY LTRIGDDSNA 150
LYLYEKELGA RTFDEE 166
Length:166
Mass (Da):19,589
Last modified:March 21, 2006 - v1
Checksum:iA8B3B5ECFBA82EEF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000253 Genomic DNA. Translation: ABD31158.1.
RefSeqiYP_500600.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD31158; ABD31158; SAOUHSC_02108.
GeneIDi3921180.
KEGGisao:SAOUHSC_02108.
PATRICi19581583. VBIStaAur99865_1913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000253 Genomic DNA. Translation: ABD31158.1 .
RefSeqi YP_500600.1. NC_007795.1.

3D structure databases

ProteinModelPortali Q2FWZ8.
SMRi Q2FWZ8. Positions 1-161.
ModBasei Search...

Protein-protein interaction databases

STRINGi 93061.SAOUHSC_02108.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD31158 ; ABD31158 ; SAOUHSC_02108 .
GeneIDi 3921180.
KEGGi sao:SAOUHSC_02108.
PATRICi 19581583. VBIStaAur99865_1913.

Phylogenomic databases

eggNOGi COG1528.
HOGENOMi HOG000223382.
KOi K02217.
OMAi FANFYIQ.
OrthoDBi EOG6G4W12.

Enzyme and pathway databases

BioCyci SAUR93061:GIWJ-2053-MONOMER.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Staphylococcus aureus NCTC 8325 genome."
    Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
    (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 8325.
  2. "PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in Staphylococcus aureus."
    Horsburgh M.J., Clements M.O., Crossley H., Ingham E., Foster S.J.
    Infect. Immun. 69:3744-3754(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-10, REGULATION BY PERR.
  3. "The staphylococcal ferritins are differentially regulated in response to iron and manganese and via perR and fur."
    Morrissey J.A., Cockayne A., Brummell K., Williams P.
    Infect. Immun. 72:972-979(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY IRON, REGULATION BY PERR AND FUR.

Entry informationi

Entry nameiFTN_STAA8
AccessioniPrimary (citable) accession number: Q2FWZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 21, 2006
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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