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Q2FWZ8 (FTN_STAA8) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin

EC=1.16.3.1
Gene names
Name:ftnA
Ordered Locus Names:SAOUHSC_02108
OrganismStaphylococcus aureus (strain NCTC 8325) [Reference proteome] [HAMAP]
Taxonomic identifier93061 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length166 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Iron-storage protein By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subcellular location

Cytoplasm By similarity.

Induction

Induced by iron. Repressed by PerR. Negatively regulated by Fur. In addition, is regulated in a PerR-independent way under metal-depleted conditions. Ref.2 Ref.3

Sequence similarities

Belongs to the ferritin family. Prokaryotic subfamily.

Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
   Biological processIron storage
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 166165Ferritin
PRO_0000295894

Regions

Domain2 – 145144Ferritin-like diiron

Sites

Metal binding171Iron 1 By similarity
Metal binding501Iron 1 By similarity
Metal binding501Iron 2 By similarity
Metal binding531Iron 1 By similarity
Metal binding941Iron 2 By similarity
Metal binding1271Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2FWZ8 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: A8B3B5ECFBA82EEF

FASTA16619,589
        10         20         30         40         50         60 
MLSKNLLEAL NDQMNHEYFA AHAYMAMAAY CDKESYEGFA NFFIQQAKEE RFHGQKIYNY 

        70         80         90        100        110        120 
INDRGAHAEF RAVSAPKIDF SSILETFKDS LSQEQEVTRR FYNLSEIARQ DKDYATISFL 

       130        140        150        160 
NWFLDEQVEE ESMFETHINY LTRIGDDSNA LYLYEKELGA RTFDEE 

« Hide

References

« Hide 'large scale' references
[1]"The Staphylococcus aureus NCTC 8325 genome."
Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
(In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 8325.
[2]"PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in Staphylococcus aureus."
Horsburgh M.J., Clements M.O., Crossley H., Ingham E., Foster S.J.
Infect. Immun. 69:3744-3754(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-10, REGULATION BY PERR.
[3]"The staphylococcal ferritins are differentially regulated in response to iron and manganese and via perR and fur."
Morrissey J.A., Cockayne A., Brummell K., Williams P.
Infect. Immun. 72:972-979(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY IRON, REGULATION BY PERR AND FUR.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000253 Genomic DNA. Translation: ABD31158.1.
RefSeqYP_500600.1. NC_007795.1.

3D structure databases

ProteinModelPortalQ2FWZ8.
SMRQ2FWZ8. Positions 1-161.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING93061.SAOUHSC_02108.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD31158; ABD31158; SAOUHSC_02108.
GeneID3921180.
KEGGsao:SAOUHSC_02108.
PATRIC19581583. VBIStaAur99865_1913.

Phylogenomic databases

eggNOGCOG1528.
HOGENOMHOG000223382.
KOK02217.
OMAFANFYIQ.
OrthoDBEOG6G4W12.

Enzyme and pathway databases

BioCycSAUR93061:GIWJ-2053-MONOMER.

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTN_STAA8
AccessionPrimary (citable) accession number: Q2FWZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 21, 2006
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families