Q2FWZ8 (FTN_STAA8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferritin
EC=1.16.3.1

Gene names

Name:	ftnA
Ordered Locus Names:	SAOUHSC_02108

Organism

Staphylococcus aureus (strain NCTC 8325) [Reference proteome] [HAMAP]

Taxonomic identifier

93061 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	166 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Iron-storage protein By similarity.
Catalytic activity	4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
Subcellular location	Cytoplasm By similarity.
Induction	Induced by iron. Repressed by PerR. Negatively regulated by Fur. In addition, is regulated in a PerR-independent way under metal-depleted conditions. Ref.2 Ref.3
Sequence similarities	Belongs to the ferritin family. Prokaryotic subfamily. Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
Biological process	Iron storage
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW iron ion transport Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ferric iron binding Inferred from electronic annotation. Source: InterPro ferroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 166	165	Ferritin		PRO_0000295894
Regions
	Domain	2 – 145	144	Ferritin-like diiron
Sites
	Metal binding	17	1	Iron 1 By similarity
	Metal binding	50	1	Iron 1 By similarity
	Metal binding	50	1	Iron 2 By similarity
	Metal binding	53	1	Iron 1 By similarity
	Metal binding	94	1	Iron 2 By similarity
	Metal binding	127	1	Iron 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2FWZ8 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: A8B3B5ECFBA82EEF	FASTA	166	19,589
	10 20 30 40 50 60 MLSKNLLEAL NDQMNHEYFA AHAYMAMAAY CDKESYEGFA NFFIQQAKEE RFHGQKIYNY 70 80 90 100 110 120 INDRGAHAEF RAVSAPKIDF SSILETFKDS LSQEQEVTRR FYNLSEIARQ DKDYATISFL 130 140 150 160 NWFLDEQVEE ESMFETHINY LTRIGDDSNA LYLYEKELGA RTFDEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 8325.
[2]	"PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in Staphylococcus aureus." Horsburgh M.J., Clements M.O., Crossley H., Ingham E., Foster S.J. Infect. Immun. 69:3744-3754(2001) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-10, REGULATION BY PERR.
[3]	"The staphylococcal ferritins are differentially regulated in response to iron and manganese and via perR and fur." Morrissey J.A., Cockayne A., Brummell K., Williams P. Infect. Immun. 72:972-979(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION BY IRON, REGULATION BY PERR AND FUR.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000253 Genomic DNA. Translation: ABD31158.1.
RefSeq	YP_500600.1. NC_007795.1.
3D structure databases
ProteinModelPortal	Q2FWZ8.
SMR	Q2FWZ8. Positions 1-161.
ModBase	Search...
Protein-protein interaction databases
STRING	93061.SAOUHSC_02108.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABD31158; ABD31158; SAOUHSC_02108.
GeneID	3921180.
KEGG	sao:SAOUHSC_02108.
PATRIC	19581583. VBIStaAur99865_1913.
Phylogenomic databases
eggNOG	COG1528.
HOGENOM	HOG000223382.
KO	K02217.
OMA	DYLNRIG.
ProtClustDB	CLSK885632.
Enzyme and pathway databases
BioCyc	SAUR93061:GIWJ-2053-MONOMER.
Family and domain databases
Gene3D	1.20.1260.10. 1 hit.
InterPro	IPR001519. Ferritin. IPR009040. Ferritin-like_diiron. IPR009078. Ferritin-like_SF. IPR012347. Ferritin-rel. IPR008331. Ferritin_DPS_dom. [Graphical view]
PANTHER	PTHR11431. PTHR11431. 1 hit.
Pfam	PF00210. Ferritin. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
PROSITE	PS50905. FERRITIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTN_STAA8

Accession

Primary (citable) accession number: Q2FWZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	March 21, 2006
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program