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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Manganese 1UniRule annotation
Metal bindingi13 – 131Manganese 1UniRule annotation
Metal bindingi15 – 151Manganese 2UniRule annotation
Metal bindingi75 – 751Manganese 1UniRule annotation
Metal bindingi75 – 751Manganese 2UniRule annotation
Metal bindingi97 – 971Manganese 2UniRule annotation
Metal bindingi149 – 1491Manganese 2UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-2083-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaCUniRule annotation
Ordered Locus Names:SAOUHSC_02140
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Probable manganese-dependent inorganic pyrophosphatasePRO_1000012320Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02140.

Structurei

3D structure databases

ProteinModelPortaliQ2FWY1.
SMRiQ2FWY1. Positions 2-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.
OrthoDBiEOG6F81QM.

Family and domain databases

HAMAPiMF_00207. PPase_C.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2FWY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTYIFGHK NPDTDAISSA IIMAEFEQLR GNSGAKAYRL GDVSAETQFA
60 70 80 90 100
LDTFNVPAPE LLTDDLDGQD VILVDHNEFQ QSSDTIASAT IKHVIDHHRI
110 120 130 140 150
ANFETAGPLC YRAEPVGCTA TILYKMFRER GFEIKPEIAG LMLSAIISDS
160 170 180 190 200
LLFKSPTCTQ QDVKAAEELK DIAKVDIQKY GLDMLKAGAS TTDKSVEFLL
210 220 230 240 250
NMDAKSFTMG DYVTRIAQVN AVDLDEVLNR KEDLEKEMLA VSAQEKYDLF
260 270 280 290 300
VLVVTDIINS DSKILVVGAE KDKVGEAFNV QLEDDMAFLS GVVSRKKQIV

PQITEALTK
Length:309
Mass (Da):34,069
Last modified:March 21, 2006 - v1
Checksum:i39EB877DA5E485A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD31188.1.
RefSeqiWP_001140871.1. NC_007795.1.
YP_500630.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD31188; ABD31188; SAOUHSC_02140.
GeneIDi3921837.
KEGGisao:SAOUHSC_02140.
PATRICi19581639. VBIStaAur99865_1941.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD31188.1.
RefSeqiWP_001140871.1. NC_007795.1.
YP_500630.1. NC_007795.1.

3D structure databases

ProteinModelPortaliQ2FWY1.
SMRiQ2FWY1. Positions 2-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02140.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD31188; ABD31188; SAOUHSC_02140.
GeneIDi3921837.
KEGGisao:SAOUHSC_02140.
PATRICi19581639. VBIStaAur99865_1941.

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.
OrthoDBiEOG6F81QM.

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-2083-MONOMER.

Family and domain databases

HAMAPiMF_00207. PPase_C.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Staphylococcus aureus NCTC 8325 genome."
    Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
    (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 8325.

Entry informationi

Entry nameiPPAC_STAA8
AccessioniPrimary (citable) accession number: Q2FWY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: June 8, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.