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Protein

Low molecular weight protein-tyrosine-phosphatase PtpB

Gene

ptpB

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Dephosphorylates the phosphotyrosine-containing proteins.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei7NucleophileBy similarity1
Active sitei13By similarity1
Active sitei111Proton donorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight protein-tyrosine-phosphatase PtpB (EC:3.1.3.48)
Alternative name(s):
Phosphotyrosine phosphatase B
Short name:
PTPase B
Gene namesi
Name:ptpB
Ordered Locus Names:SAOUHSC_02356
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003006781 – 139Low molecular weight protein-tyrosine-phosphatase PtpBAdd BLAST139

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02356.

Structurei

3D structure databases

ProteinModelPortaliQ2FWE3.
SMRiQ2FWE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107WAU. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273091.
KOiK01104.
OMAiIFVCTGN.

Family and domain databases

InterProiView protein in InterPro
IPR023485. Ptyr_pPase.
IPR036196. Ptyr_pPase_sf.
IPR017867. Tyr_phospatase_low_mol_wt.
PfamiView protein in Pfam
PF01451. LMWPc. 1 hit.
PRINTSiPR00719. LMWPTPASE.
SMARTiView protein in SMART
SM00226. LMWPc. 1 hit.
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2FWE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILFVCTGN TCRSPLAESI AKEVMPNHQF ESRGIFAVNN QGVSNYVEDL
60 70 80 90 100
VEEHHLAETT LSQQFTEADL KADIILTMSY SHKELIEAHF GLQNHVFTLH
110 120 130
EYVKEAGEVI DPYGGTKEMY VHTYEELVSL ILKLKDIIC
Length:139
Mass (Da):15,788
Last modified:March 21, 2006 - v1
Checksum:i63EB2C0E2A53EA5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD31387.1.
RefSeqiWP_000697334.1. NC_007795.1.
YP_500832.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD31387; ABD31387; SAOUHSC_02356.
GeneIDi31214848.
3919399.
KEGGisao:SAOUHSC_02356.
PATRICifig|93061.5.peg.2133.

Similar proteinsi

Entry informationi

Entry nameiPTPB_STAA8
AccessioniPrimary (citable) accession number: Q2FWE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 21, 2006
Last modified: October 25, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families