Q2FWD9 (Q2FWD9_STAA8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thymidine kinase HAMAP MF_00124 RuleBase RU000544
EC=2.7.1.21 HAMAP MF_00124 RuleBase RU000544

Gene names

Name:	tdk HAMAP MF_00124
Ordered Locus Names:	SAOUHSC_02360

Organism

Staphylococcus aureus (strain NCTC 8325)

Taxonomic identifier

93061 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP MF_00124 RuleBase RU000544 SAAS SAAS020634
Subunit structure	Homotetramer By similarity. HAMAP MF_00124 SAAS SAAS020634
Subcellular location	Cytoplasm By similarity HAMAP MF_00124 SAAS SAAS020634.
Sequence similarities	Belongs to the thymidine kinase family. HAMAP MF_00124 RuleBase RU004165

Ontologies

Keywords
Biological process	DNA synthesis HAMAP MF_00124 SAAS SAAS020634 RuleBase RU000544
Cellular component	Cytoplasm HAMAP MF_00124 SAAS SAAS020634
Ligand	ATP-binding HAMAP MF_00124 SAAS SAAS020634 RuleBase RU000544 Metal-binding HAMAP MF_00124 SAAS SAAS020634 Nucleotide-binding Zinc HAMAP MF_00124 SAAS SAAS020634
Molecular function	Kinase HAMAP MF_00124 SAAS SAAS020634 RuleBase RU000544 EMBL ABD31391.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidine kinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	15 – 22	8	ATP By similarity HAMAP MF_00124
	Nucleotide binding	88 – 91	4	ATP By similarity HAMAP MF_00124
Sites
	Active site	89	1	Proton acceptor By similarity HAMAP MF_00124
	Metal binding	145	1	Zinc By similarity HAMAP MF_00124
	Metal binding	148	1	Zinc By similarity HAMAP MF_00124
	Metal binding	183	1	Zinc By similarity HAMAP MF_00124
	Metal binding	186	1	Zinc By similarity HAMAP MF_00124

Sequences

	Sequence		Length	Mass (Da)
	Q2FWD9 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: C1EC76B7C5645909	FASTA	199	22,214
	10 20 30 40 50 60 MYETYHSGWI ECITGSMFSG KSEELIRRLR RGIYAKQKVV VFKPAIDDRY HKEKVVSHNG 70 80 90 100 110 120 NAIEAINISK ASEIMTHDLT NVDVIGIDEV QFFDDEIVSI VEKLSADGHR VIVAGLDMDF 130 140 150 160 170 180 RGEPFEPMPK LMAVSEQVTK LQAVCAVCGS SSSRTQRLIN GKPAKIDDPI ILVGANESYE 190 PRCRAHHIVA PSDNNKEEL

References

[1]	"The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 8325.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000253 Genomic DNA. Translation: ABD31391.1.
RefSeq	YP_500836.1. NC_007795.1.
3D structure databases
ProteinModelPortal	Q2FWD9.
SMR	Q2FWD9. Positions 1-189.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2FWD9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000029677; EBSTAP00000028628; EBSTAG00000029675.
GeneID	3919403.
GenomeReviews	Gene locus SAOUHSC_02360 in contig CP000253_GR.
KEGG	sao:SAOUHSC_02360.
PATRIC	19582041. VBIStaAur99865_2137.
Phylogenomic databases
eggNOG	COG1435.
GeneTree	EBGT00050000023861.
HOGENOM	HBG522108.
OMA	EPRCRHH.
PhylomeDB	Q2FWD9.
ProtClustDB	PRK04296.
Enzyme and pathway databases
BioCyc	SAUR93061:SAOUHSC_02360-MONOMER.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase. [Tree]
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
KO	K00857.
PANTHER	PTHR11441. TK_cell. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q2FWD9_STAA8

Accession

Primary (citable) accession number: Q2FWD9

Entry history

Integrated into UniProtKB/TrEMBL:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)