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Protein

4,4'-diaponeurosporen-aldehyde dehydrogenase

Gene

aldH

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the oxidation of 4,4'-diaponeurosporen-4-al to yield 4,4'-diaponeurosporenoic acid.1 Publication

Catalytic activityi

4,4'-diaponeurosporenal + NAD+ + H2O = 4,4'-diaponeurosporenoate + NADH.1 Publication

Pathwayi: staphyloxanthin biosynthesis

This protein is involved in the subpathway that synthesizes staphyloxanthin from farnesyl diphosphate.1 Publication This subpathway is part of the pathway staphyloxanthin biosynthesis, which is itself part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway staphyloxanthin biosynthesis and in Carotenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei245Proton acceptorBy similarity1
Binding sitei246NAD; via carbonyl oxygenBy similarity1
Active sitei279NucleophileBy similarity1
Binding sitei379NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi146 – 147NADBy similarity2
Nucleotide bindingi223 – 224NADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarotenoid biosynthesis, Virulence
LigandNAD

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-2232-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
4,4'-diaponeurosporen-aldehyde dehydrogenase1 Publication (EC:1.2.1.-1 Publication)
Alternative name(s):
4,4'-diaponeurosporenal dehydrogenase1 Publication
Gene namesi
Name:aldH1 Publication
Ordered Locus Names:SAOUHSC_02363
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene are unable to produce staphyloxanthin and cause accumulation of 4,4'- diaponeurosporen-4-al.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002935591 – 4754,4'-diaponeurosporen-aldehyde dehydrogenaseAdd BLAST475

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02363

Structurei

3D structure databases

ProteinModelPortaliQ2FWD6
SMRiQ2FWD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105C26 Bacteria
COG1012 LUCA
HOGENOMiHOG000271505
KOiK00128
OMAiRHVMIKH

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR012394 Aldehyde_DH_NAD(P)
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF036492 ALDH, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Q2FWD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDYTKQYIN GEWVESNSNE TIEVINPATE EVIGKVAKGN KADVDKAVEA
60 70 80 90 100
ADDVYLEFRH TSVKERQALL DKIVKEYENR KDDIVQAITD ELGAPLSLSE
110 120 130 140 150
RVHYQMGLNH FVAARDALDN YEFEERRGDD LVVKEAIGVS GLITPWNFPT
160 170 180 190 200
NQTSLKLAAA FAAGSPVVLK PSEETPFAAV ILAEIFDKVG VPKGVFNLVN
210 220 230 240 250
GDGAGVGNPL SEHPKVRMMS FTGSGPTGSK IMEKAAKDFK KVSLELGGKS
260 270 280 290 300
PYIVLDDVDI KEAAKATTGK VVNNTGQVCT AGTRVLVPNK IKDAFLAELK
310 320 330 340 350
EQFSQVRVGN PREDGTQVGP IISKKQFDQV QNYINKGIEE GAELFYGGPG
360 370 380 390 400
KPEGLEKGYF ARPTIFINVD NQMTIAQEEI FGPVMSVITY NDLDEAIQIA
410 420 430 440 450
NDTKYGLAGY VIGKDKETLH KVARSIEAGT VEINEAGRKP DLPFGGYKQS
460 470
GLGREWGDYG IEEFLEVKSI AGYFK
Length:475
Mass (Da):51,969
Last modified:March 21, 2006 - v1
Checksum:i03C66ED0B87BC09A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA Translation: ABD31394.1
RefSeqiWP_001206093.1, NC_007795.1
YP_500839.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD31394; ABD31394; SAOUHSC_02363
GeneIDi3919406
KEGGisao:SAOUHSC_02363
PATRICifig|93061.5.peg.2140

Similar proteinsi

Entry informationi

Entry nameiALDH_STAA8
AccessioniPrimary (citable) accession number: Q2FWD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 21, 2006
Last modified: April 25, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health