Q2FWB9 (Q2FWB9_STAA8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase 2 HAMAP MF_00114
Short name=DERA 2 HAMAP MF_00114
EC=4.1.2.4 HAMAP MF_00114

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase 2 HAMAP MF_00114
Phosphodeoxyriboaldolase 2 HAMAP MF_00114

Gene names

Name:	deoC2 HAMAP MF_00114
Ordered Locus Names:	SAOUHSC_02379

Organism

Staphylococcus aureus (strain NCTC 8325)

Taxonomic identifier

93061 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114 SAAS SAAS022979
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114 SAAS SAAS022979
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114 SAAS SAAS022979
Subcellular location	Cytoplasm By similarity HAMAP MF_00114 SAAS SAAS022979.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. HAMAP MF_00114

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00114 SAAS SAAS022979
Ligand	Schiff base SAAS SAAS022979 HAMAP MF_00114
Molecular function	Lyase HAMAP MF_00114 SAAS SAAS022979 EMBL ABD31410.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	151	1	Schiff-base intermediate with acetaldehyde By similarity HAMAP MF_00114
	Active site	180	1	By similarity HAMAP MF_00114

Sequences

	Sequence		Length	Mass (Da)
	Q2FWB9 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 8382DCE860586865	FASTA	220	23,327
	10 20 30 40 50 60 MNSAKLIDHT LLKPESTRTQ IDQIIDEAKA YHFKSVCVNP THVKYAAERL ADSEVLVCTV 70 80 90 100 110 120 IGFPLGASTT ATKAFETEDA IQNGADEIDM VINIGALKDG RFDDVQQDIE AVVKAAKGHT 130 140 150 160 170 180 VKVIIETVLL DHDEIVKASE LTKAAGADFV KTSTGFAGGG ATAEDVKLMK DTVGADIEVK 190 200 210 220 ASGGVRNLED FNKMVEAGAT RIGASAGVQI MQGLEADSDY

References

[1]	"The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 8325.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000253 Genomic DNA. Translation: ABD31410.1.
RefSeq	YP_500856.1. NC_007795.1.
3D structure databases
ProteinModelPortal	Q2FWB9.
SMR	Q2FWB9. Positions 3-217.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2FWB9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000028698; EBSTAP00000027649; EBSTAG00000028697.
GeneID	3919422.
GenomeReviews	Gene locus SAOUHSC_02379 in contig CP000253_GR.
KEGG	sao:SAOUHSC_02379.
PATRIC	19582077. VBIStaAur99865_2155.
Phylogenomic databases
eggNOG	COG0274.
GeneTree	EBGT00050000024092.
HOGENOM	HBG636421.
OMA	CLEAREN.
PhylomeDB	Q2FWB9.
ProtClustDB	PRK00507.
Enzyme and pathway databases
BioCyc	SAUR93061:SAOUHSC_02379-MONOMER.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q2FWB9_STAA8

Accession

Primary (citable) accession number: Q2FWB9

Entry history

Integrated into UniProtKB/TrEMBL:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)