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Q2FVV9

- FDHL_STAA8

UniProt

Q2FVV9 - FDHL_STAA8

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Protein
Putative formate dehydrogenase SAOUHSC_02582
Gene
SAOUHSC_02582
Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Binds 1 2Fe-2S cluster By similarity.
Binds 4 4Fe-4S clusters By similarity.
Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi37 – 371Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi48 – 481Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi51 – 511Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi63 – 631Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi95 – 951Iron-sulfur 2 (4Fe-4S); via tele nitrogen By similarity
Metal bindingi99 – 991Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi102 – 1021Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi109 – 1091Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi147 – 1471Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi150 – 1501Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi153 – 1531Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi157 – 1571Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi190 – 1901Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi193 – 1931Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi196 – 1961Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi200 – 2001Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi264 – 2641Iron-sulfur 5 (4Fe-4S) By similarity
Metal bindingi267 – 2671Iron-sulfur 5 (4Fe-4S) By similarity
Metal bindingi271 – 2711Iron-sulfur 5 (4Fe-4S) By similarity
Metal bindingi299 – 2991Iron-sulfur 5 (4Fe-4S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. electron carrier activity Source: InterPro
  4. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  5. molybdenum ion binding Source: InterPro

GO - Biological processi

  1. formate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-2512-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative formate dehydrogenase SAOUHSC_02582 (EC:1.2.1.2)
Gene namesi
Ordered Locus Names:SAOUHSC_02582
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000008816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 984984Putative formate dehydrogenase SAOUHSC_02582
PRO_0000304134Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02582.

Structurei

3D structure databases

ProteinModelPortaliQ2FVV9.
SMRiQ2FVV9. Positions 1-208, 257-942.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 79772Fe-2S ferredoxin-type
Add
BLAST
Domaini138 – 165284Fe-4S ferredoxin-type 1
Add
BLAST
Domaini181 – 211314Fe-4S ferredoxin-type 2
Add
BLAST
Domaini257 – 313574Fe-4S Mo/W bis-MGD-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni252 – 984733Formate dehydrogenase
Add
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG3383.
HOGENOMiHOG000031440.
KOiK00123.
OMAiMHIDAFV.
OrthoDBiEOG6CVV7G.

Family and domain databases

InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
PfamiPF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036643. FDH_alpha. 1 hit.
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2FVV9-1 [UniParc]FASTAAdd to Basket

« Hide

MQEHLVVTLD GKDYLVEPGT NLLEFIKSQD TFVPSICYNE SMGPIQTCDT    50
CTVEIDGKIE RSCSTVIDRP MTVNTVNNDV KDAQKEALDR ILEKHMLYCT 100
VCDYNNGDCE IHNTMDAWGL QHQTYEYKEK PYEKDYGPFY RYDPNQCILC 150
GRCVEACQDI EVNETIRIDW DREHPRVIWD NDVPINESSC VSCGQCATVC 200
PCNAMMEVNM EGNAGYMTDT EPGSLAAMID LTKKAEPGYG PLFAISDSEA 250
EMRKERIKKT KTVCTYCGVG CSFEVWTKDR EILKVQPSHD SPANKIATCV 300
KGKFSWGHIN SDQRLTKPLV RKNGEFHEVE WDEALNVIAD NFTAIKEKHG 350
PDALSFISSS KATNEESYLM QKLARQVIGT NNVDNCSRYC QAPATKGLFR 400
TVGHGGDSGS IEDLEKAAMS VLIGTNTAEA HPVIASRMKR AQKLFGQKIH 450
VFDIRKHEMA ERADRFYQPK PGTDLAWLSA VTKYIIDHDL HDKAFIDEWV 500
DDFDEYYKSL ETFTMAFAEE ATGIPESELI KFAEECAKAE SVVICWAMGI 550
TQQDIGSDSS TAISNLLLVT GNYRRPGTGA YPLRGHNNVQ GCSDMGSMPD 600
KITGYQSIEA DDIRAKFEKE YGVKLNPKAG KDNHEMVEGI HDGEVHSLYL 650
YGEDTGIVDS NINFVQAAFE KLDFMVVQDE FLTFTATYAD VVLPASPSLE 700
KDGTFTNTER RIQRLYQALE PLGDSKPDWK IFQAIANRLG FDWNYKHPSE 750
IMDEVARLTP LYAGVSYDRL EGFNSLQWPV QPDGTDEPIL YLEGFNFDNG 800
KAKLFPLSFD NYFKQDEIYD IHVNNGRLLE HFHEGNMTYQ TPMIKYKVPR 850
AFVEISPELA EDRGIHEGAE VKLISETGEA VLQVHVTDRV KGKEIYIPLN 900
NDAMENGDLG AINLLTNSDV DQYTDTPSYK RTSCRLEVIT KRGKSPLNPN 950
NFRVNKKRQP QYSVQVQKKW ERSDYVFPGN QVDK 984
Length:984
Mass (Da):111,244
Last modified:March 21, 2006 - v1
Checksum:i9EE43448C906B8DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000253 Genomic DNA. Translation: ABD31593.1.
RefSeqiYP_501044.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD31593; ABD31593; SAOUHSC_02582.
GeneIDi3921578.
KEGGisao:SAOUHSC_02582.
PATRICi19582450. VBIStaAur99865_2331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000253 Genomic DNA. Translation: ABD31593.1 .
RefSeqi YP_501044.1. NC_007795.1.

3D structure databases

ProteinModelPortali Q2FVV9.
SMRi Q2FVV9. Positions 1-208, 257-942.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93061.SAOUHSC_02582.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD31593 ; ABD31593 ; SAOUHSC_02582 .
GeneIDi 3921578.
KEGGi sao:SAOUHSC_02582.
PATRICi 19582450. VBIStaAur99865_2331.

Phylogenomic databases

eggNOGi COG3383.
HOGENOMi HOG000031440.
KOi K00123.
OMAi MHIDAFV.
OrthoDBi EOG6CVV7G.

Enzyme and pathway databases

BioCyci SAUR93061:GIWJ-2512-MONOMER.

Family and domain databases

InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view ]
Pfami PF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF036643. FDH_alpha. 1 hit.
SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR01591. Fdh-alpha. 1 hit.
PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Staphylococcus aureus NCTC 8325 genome."
    Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
    (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 8325.

Entry informationi

Entry nameiFDHL_STAA8
AccessioniPrimary (citable) accession number: Q2FVV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 21, 2006
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi