ID   BIOW_STAA8              Reviewed;         230 AA.
AC   Q2FVJ9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 16.
DE   RecName: Full=6-carboxyhexanoate--CoA ligase;
DE            EC=6.2.1.14;
DE   AltName: Full=Pimeloyl-CoA synthase;
GN   Name=bioW; OrderedLocusNames=SAOUHSC_02712;
OS   Staphylococcus aureus (strain NCTC 8325).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W.,
RA   Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC8325 genome.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transforms pimelate into pimeloyl-CoA (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + 6-carboxyhexanoate + CoA = AMP +
CC       diphosphate + 6-carboxyhexanoyl-CoA.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis; 6-
CC       carboxyhexanoyl-CoA from 6-carboxyhexanoate: step 1/1.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the bioW family.
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DR   EMBL; CP000253; ABD31720.1; -; Genomic_DNA.
DR   RefSeq; YP_501174.1; -.
DR   GeneID; 3919731; -.
DR   GenomeReviews; CP000253_GR; SAOUHSC_02712.
DR   KEGG; sao:SAOUHSC_02712; -.
DR   HOGENOM; Q2FVJ9; -.
DR   OMA; Q2FVJ9; TVDAIAI.
DR   BioCyc; SAUR93061:SAOUHSC_02712-MON; -.
DR   GO; GO:0042410; F:6-carboxyhexanoate-CoA ligase activity; IEA:HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0009102; P:biotin biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00668; -; 1.
DR   InterPro; IPR005499; BioW.
DR   Pfam; PF03744; BioW; 1.
DR   ProDom; PD017229; BioW; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Biotin biosynthesis; Complete proteome; Ligase;
KW   Magnesium; Nucleotide-binding.
FT   CHAIN         1    230       6-carboxyhexanoate--CoA ligase.
FT                                /FTId=PRO_1000044697.
SQ   SEQUENCE   230 AA;  26092 MW;  345AB71E281355DE CRC64;
     MYSIKMRSSN QDVHISGAET ICEFDKIEQT VQRFYNKGFF HENGQPDFLN IKIQKIMEPI
     QQIKALQIIE DDKANLQHLT QECGVTEQAL NQGMTYIKNE TVYTGAIILS AISGKRLDSF
     GQRGIRATHF SFEDINNKGD LNERVTDALA IASCINAHPY VKGELCVSDD LTYTTGYFAA
     AKIGYHRLFD IKPVNTRYGG RIIFVDDCID LNHYISFLES TPKQVVYETV
//