Q2FVJ9 (BIOW_STAA8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-carboxyhexanoate--CoA ligase
EC=6.2.1.14

Alternative name(s):
Pimeloyl-CoA synthase

Gene names

Name:	bioW
Ordered Locus Names:	SAOUHSC_02712

Organism

Staphylococcus aureus (strain NCTC 8325)

Taxonomic identifier

93061 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP By similarity. HAMAP MF_00668
Catalytic activity	ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA. HAMAP MF_00668
Cofactor	Magnesium By similarity. HAMAP MF_00668
Pathway	Metabolic intermediate metabolism; pimeloyl-CoA biosynthesis; pimeloyl-CoA from pimelate: step 1/1. HAMAP MF_00668
Subunit structure	Homodimer By similarity. HAMAP MF_00668
Sequence similarities	Belongs to the BioW family.

Ontologies

Keywords
Biological process	Biotin biosynthesis
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	biotin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	6-carboxyhexanoate-CoA ligase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	6-carboxyhexanoate--CoA ligase HAMAP MF_00668		PRO_1000044697

Sequences

	Sequence		Length	Mass (Da)
	Q2FVJ9 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 345AB71E281355DE	FASTA	230	26,092
	10 20 30 40 50 60 MYSIKMRSSN QDVHISGAET ICEFDKIEQT VQRFYNKGFF HENGQPDFLN IKIQKIMEPI 70 80 90 100 110 120 QQIKALQIIE DDKANLQHLT QECGVTEQAL NQGMTYIKNE TVYTGAIILS AISGKRLDSF 130 140 150 160 170 180 GQRGIRATHF SFEDINNKGD LNERVTDALA IASCINAHPY VKGELCVSDD LTYTTGYFAA 190 200 210 220 230 AKIGYHRLFD IKPVNTRYGG RIIFVDDCID LNHYISFLES TPKQVVYETV

References

[1]	"The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 8325.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000253 Genomic DNA. Translation: ABD31720.1.
RefSeq	YP_501174.1. NC_007795.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2FVJ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000028926; EBSTAP00000027877; EBSTAG00000028924.
GeneID	3919731.
GenomeReviews	Gene locus SAOUHSC_02712 in contig CP000253_GR.
KEGG	sao:SAOUHSC_02712.
PATRIC	19582701. VBIStaAur99865_2456.
Phylogenomic databases
eggNOG	COG1424.
GeneTree	EBGT00050000025018.
HOGENOM	HBG507782.
OMA	TTGYVAT.
ProtClustDB	PRK01322.
Enzyme and pathway databases
BioCyc	SAUR93061:SAOUHSC_02712-MONOMER.
Family and domain databases
HAMAP	MF_00668. BioW. [Tree]
InterPro	IPR005499. BioW. [Graphical view]
KO	K01906.
Pfam	PF03744. BioW. 1 hit. [Graphical view]
ProDom	PD017229. BioW. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

BIOW_STAA8

Accession

Primary (citable) accession number: Q2FVJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program