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Protein

6-carboxyhexanoate--CoA ligase

Gene

bioW

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.UniRule annotation

Catalytic activityi

ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: pimeloyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes pimeloyl-CoA from pimelate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 6-carboxyhexanoate--CoA ligase (bioW)
This subpathway is part of the pathway pimeloyl-CoA biosynthesis, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pimeloyl-CoA from pimelate, the pathway pimeloyl-CoA biosynthesis and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processBiotin biosynthesis
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00999; UER00351.

Names & Taxonomyi

Protein namesi
Recommended name:
6-carboxyhexanoate--CoA ligaseUniRule annotation (EC:6.2.1.14UniRule annotation)
Alternative name(s):
Pimeloyl-CoA synthaseUniRule annotation
Gene namesi
Name:bioWUniRule annotation
Ordered Locus Names:SAOUHSC_02712
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000446971 – 2306-carboxyhexanoate--CoA ligaseAdd BLAST230

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02712.

Structurei

3D structure databases

SMRiQ2FVJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BioW family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108W8G. Bacteria.
COG1424. LUCA.
HOGENOMiHOG000253976.
KOiK01906.
OMAiLCWSDDP.

Family and domain databases

HAMAPiMF_00668. BioW. 1 hit.
InterProiView protein in InterPro
IPR005499. BioW.
PfamiView protein in Pfam
PF03744. BioW. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD017229. BioW. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2FVJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSIKMRSSN QDVHISGAET ICEFDKIEQT VQRFYNKGFF HENGQPDFLN
60 70 80 90 100
IKIQKIMEPI QQIKALQIIE DDKANLQHLT QECGVTEQAL NQGMTYIKNE
110 120 130 140 150
TVYTGAIILS AISGKRLDSF GQRGIRATHF SFEDINNKGD LNERVTDALA
160 170 180 190 200
IASCINAHPY VKGELCVSDD LTYTTGYFAA AKIGYHRLFD IKPVNTRYGG
210 220 230
RIIFVDDCID LNHYISFLES TPKQVVYETV
Length:230
Mass (Da):26,092
Last modified:March 21, 2006 - v1
Checksum:i345AB71E281355DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD31720.1.
RefSeqiWP_000286875.1. NC_007795.1.
YP_501174.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD31720; ABD31720; SAOUHSC_02712.
GeneIDi3919731.
KEGGisao:SAOUHSC_02712.
PATRICifig|93061.5.peg.2456.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBIOW_STAA8
AccessioniPrimary (citable) accession number: Q2FVJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: June 7, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families