Reviewed, UniProtKB/Swiss-Prot Q2FVC1 (PGCA_STAA8)

Names and origin

Protein names

Recommended name:
    Phosphoglucomutase
      Short name=PGM
    EC=5.4.2.2
Alternative name(s):
    Alpha-phosphoglucomutase
    Glucose phosphomutase

Gene names

Name:	pgcA
Ordered Locus Names:	SAOUHSC_02793

Organism

Staphylococcus aureus (strain NCTC 8325) [Complete proteome] [HAMAP]

Taxonomic identifier

93061 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	552 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the interconversion between glucose-6-phosphate and alpha-glucose-1-phosphate Probable. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in the S.aureus membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA).
Catalytic activity	Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Pathway	Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis. Ref.2
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglucomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 552	552	Phosphoglucomutase		PRO_0000308336
Sites
	Active site	143	1	Phosphoserine intermediate By similarity
	Metal binding	143	1	Magnesium; via phosphate group By similarity
	Metal binding	295	1	Magnesium By similarity
	Metal binding	297	1	Magnesium By similarity
	Metal binding	299	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2FVC1-1 [UniParc]. Last modified October 23, 2007. Version 2. Checksum: BBD3821D6991CB3A	FASTA	552	62,377
	10 20 30 40 50 60 MKGCLATMDK ELWIERANDS LVKHFYEQQS DIEQREGFES KLTFGTAGIR GKFGLGEGRL 70 80 90 100 110 120 NKFTIEKLAL GLARYLNAQT NSPTIVIHYD IRHLSTEFAQ IIANVLANHQ ITVYLPDTYK 130 140 150 160 170 180 TTPELSFAVR NLNTTAGIMI TASHNPKDYN GIKVYGSDGA QLSTDASELA SRYIEEVGDP 190 200 210 220 230 240 LQIDIPISKQ NTSYIKPFPK SVTDDYMKHI QNMIGYIPKS DLQVVFTSLH GTSVPIVPEL 250 260 270 280 290 300 LQSLNFNQFN LVEAQCKPDP NFSSVQSANP EDHRAFDQAV ELANKSHADL LISTDPDADR 310 320 330 340 350 360 LGIAERDAHG HITYFNGNQI GALLLNYRIQ QTSQLRHRLM IQSIVSSELT KSLARYNNVE 370 380 390 400 410 420 YKEVLTGFKF IAQEIRQLDD HQNMIFAFEE SYGFLSEPFV RDKDAVQIVP LIIKYASELK 430 440 450 460 470 480 LYGKTLKDEL EQIYQTVGRH EDTLFSHTLE GFEGKKKINA IMTKFRSNPP QEIQGLKVKA 490 500 510 520 530 540 IEDYLTSEVY HLDKDTTSQI NSPKSNVIRV LFDEGFIALR PSGTEPKIKL YVSLKCPNFD 550 DVAQKINAMI FS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Staphylococcus aureus NCTC8325 genome." Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Genes required for glycolipid synthesis and lipoteichoic acid anchoring in Staphylococcus aureus." Gruendling A., Schneewind O. J. Bacteriol. 189:2521-2530(2007) [PubMed: 17209021] [Abstract] Cited for: FUNCTION IN GLYCOLIPID AND LTA BIOSYNTHESIS, PATHWAY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000253 Genomic DNA. Translation: ABD31796.1. Different initiation.
RefSeq	YP_501252.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3921447.
GenomeReviews	Gene locus SAOUHSC_02793 in contig CP000253_GR.
KEGG	sao:SAOUHSC_02793.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2FVC1.
Enzyme and pathway databases
BioCyc	SAUR93061:SAOUHSC_02793-MON.
Family and domain databases
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. A-D-PHexomutase_N. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGCA_STAA8

Accession

Primary (citable) accession number: Q2FVC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	June 16, 2009
This is version 24 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)