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Protein

Copper chaperone CopZ

Gene

copZ

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Chaperone that serves for the intracellular sequestration and transport of Cu+. Delivers Cu+ to the copper-exporting P-type ATPase A (CopA) (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131CopperPROSITE-ProRule annotation
Metal bindingi16 – 161CopperPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-2797-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper chaperone CopZ
Gene namesi
Name:copZ
Ordered Locus Names:SAOUHSC_02874
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6868Copper chaperone CopZPRO_0000351280Add
BLAST

Expressioni

Developmental stagei

Highest expression during the exponential growth phase.1 Publication

Inductioni

Induced by copper and, to some extent, by ferric and lead ions.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02874.

Structurei

3D structure databases

ProteinModelPortaliQ2FV63.
SMRiQ2FV63. Positions 1-67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 6866HMAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HMA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41082MP. Bacteria.
COG2608. LUCA.
HOGENOMiHOG000038877.
KOiK07213.
OMAiNHCKMTV.

Family and domain databases

InterProiIPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR001802. MerP/CopZ.
[Graphical view]
PfamiPF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00946. HGSCAVENGER.
SUPFAMiSSF55008. SSF55008. 1 hit.
TIGRFAMsiTIGR00003. TIGR00003. 1 hit.
PROSITEiPS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2FV63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQEILNVEG MSCGHCKSAV ESALNNIDGV TSADVNLENG QVSVQYDDSK
60
VAVSQMKDAI EDQGYDVV
Length:68
Mass (Da):7,237
Last modified:March 21, 2006 - v1
Checksum:iD8DC0D1349C1BF3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD31872.1.
RefSeqiYP_501329.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD31872; ABD31872; SAOUHSC_02874.
GeneIDi3921545.
KEGGisao:SAOUHSC_02874.
PATRICi19582985. VBIStaAur99865_2598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD31872.1.
RefSeqiYP_501329.1. NC_007795.1.

3D structure databases

ProteinModelPortaliQ2FV63.
SMRiQ2FV63. Positions 1-67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02874.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD31872; ABD31872; SAOUHSC_02874.
GeneIDi3921545.
KEGGisao:SAOUHSC_02874.
PATRICi19582985. VBIStaAur99865_2598.

Phylogenomic databases

eggNOGiENOG41082MP. Bacteria.
COG2608. LUCA.
HOGENOMiHOG000038877.
KOiK07213.
OMAiNHCKMTV.

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-2797-MONOMER.

Family and domain databases

InterProiIPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR001802. MerP/CopZ.
[Graphical view]
PfamiPF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00946. HGSCAVENGER.
SUPFAMiSSF55008. SSF55008. 1 hit.
TIGRFAMsiTIGR00003. TIGR00003. 1 hit.
PROSITEiPS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOPZ_STAA8
AccessioniPrimary (citable) accession number: Q2FV63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: March 21, 2006
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.