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Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Pathway:iglycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase class 1 (fda)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei175 – 1751Proton acceptorUniRule annotation
Active sitei212 – 2121Schiff-base intermediate with dihydroxyacetone-PUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-2847-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1UniRule annotation (EC:4.1.2.13UniRule annotation)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolaseUniRule annotation
Gene namesi
Name:fdaUniRule annotation
Ordered Locus Names:SAOUHSC_02926
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000008816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Fructose-bisphosphate aldolase class 1PRO_1000045918Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02926.

Structurei

3D structure databases

ProteinModelPortaliQ2FV17.
SMRiQ2FV17. Positions 1-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3588.
HOGENOMiHOG000073502.
KOiK01623.
OMAiEPEVDIH.
OrthoDBiEOG6M6JJT.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00729. FBP_aldolase_1.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2FV17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKEQLEKMK NGKGFIAALD QSGGSTPKAL KEYGVNEDQY SNEDEMFQLV
60 70 80 90 100
HDMRTRVVTS PSFSPDKILG AILFEQTMDR EVESKYTADY LADKGVVPFL
110 120 130 140 150
KVDKGLAEEQ NGVQLMKPID NLDNLLDRAN ERHIFGTKMR SNILELNEQG
160 170 180 190 200
IKDVVEQQFE VAKQIIAKGL VPIIEPEVNI NAKDKAEIEK VLKAELKKGL
210 220 230 240 250
DSLNADQLVM LKLTIPTEPN LYKELAEHPN VVRVVVLSGG YSREKANELL
260 270 280 290
KDNAELIASF SRALASDLRA DQSKEEFDKA LGDAVESIYD ASVNKN
Length:296
Mass (Da):33,055
Last modified:March 21, 2006 - v1
Checksum:i610A2E2FBDA7EB5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD31921.1.
RefSeqiWP_001031413.1. NC_007795.1.
YP_501379.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD31921; ABD31921; SAOUHSC_02926.
GeneIDi23195762.
3921377.
KEGGisao:SAOUHSC_02926.
PATRICi19583079. VBIStaAur99865_2645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000253 Genomic DNA. Translation: ABD31921.1.
RefSeqiWP_001031413.1. NC_007795.1.
YP_501379.1. NC_007795.1.

3D structure databases

ProteinModelPortaliQ2FV17.
SMRiQ2FV17. Positions 1-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02926.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD31921; ABD31921; SAOUHSC_02926.
GeneIDi23195762.
3921377.
KEGGisao:SAOUHSC_02926.
PATRICi19583079. VBIStaAur99865_2645.

Phylogenomic databases

eggNOGiCOG3588.
HOGENOMiHOG000073502.
KOiK01623.
OMAiEPEVDIH.
OrthoDBiEOG6M6JJT.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.
BioCyciSAUR93061:GIWJ-2847-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00729. FBP_aldolase_1.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Staphylococcus aureus NCTC 8325 genome."
    Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
    (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 8325.

Entry informationi

Entry nameiALF1_STAA8
AccessioniPrimary (citable) accession number: Q2FV17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: May 27, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.