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Q2FUY1

- ARCR_STAA8

UniProt

Q2FUY1 - ARCR_STAA8

Protein

HTH-type transcriptional regulator ArcR

Gene

arcR

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Positively regulates the expression of the arcABDCR operon under anaerobic conditions, by binding to the consensus motif 5'-TGTGAN6TCACA-3', thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi40 – 12990cNMPAdd
    BLAST
    DNA bindingi188 – 20720H-T-H motifBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. cAMP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: CACAO
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    cAMP, cAMP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSAUR93061:GIWJ-2883-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional regulator ArcR
    Gene namesi
    Name:arcR
    Ordered Locus Names:SAOUHSC_02964
    OrganismiStaphylococcus aureus (strain NCTC 8325)
    Taxonomic identifieri93061 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000008816: Chromosome

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 234234HTH-type transcriptional regulator ArcRPRO_0000349414Add
    BLAST

    Expressioni

    Inductioni

    Induced by arginine and anaerobic growth during the stationary phase. Repressed under aerobic conditions independently of the growth phase and by glucose catabolic repression.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi93061.SAOUHSC_02964.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2FUY1.
    SMRiQ2FUY1. Positions 31-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini155 – 22874HTH crp-typeAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000022896.
    OMAiERVNQNG.
    OrthoDBiEOG6QRWC5.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR014710. RmlC-like_jellyroll.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2FUY1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY    50
    FSPQESSNIY FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV 100
    NELCTALTDC TVLGLPRELM AFLCKANDDI FLTLFALIND NEQQHMNYNM 150
    ALTSKFAKDR IIKLICHLCQ TVGYDQDEFY EIKQFLTIQL MSDMAGISRE 200
    TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV 234
    Length:234
    Mass (Da):27,428
    Last modified:March 21, 2006 - v1
    Checksum:iA26B08D8A1EA396E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ566750 Genomic DNA. Translation: CAD98185.1.
    CP000253 Genomic DNA. Translation: ABD31954.1.
    RefSeqiYP_501415.1. NC_007795.1.

    Genome annotation databases

    EnsemblBacteriaiABD31954; ABD31954; SAOUHSC_02964.
    GeneIDi3921666.
    KEGGisao:SAOUHSC_02964.
    PATRICi19583137. VBIStaAur99865_2674.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ566750 Genomic DNA. Translation: CAD98185.1 .
    CP000253 Genomic DNA. Translation: ABD31954.1 .
    RefSeqi YP_501415.1. NC_007795.1.

    3D structure databases

    ProteinModelPortali Q2FUY1.
    SMRi Q2FUY1. Positions 31-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93061.SAOUHSC_02964.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD31954 ; ABD31954 ; SAOUHSC_02964 .
    GeneIDi 3921666.
    KEGGi sao:SAOUHSC_02964.
    PATRICi 19583137. VBIStaAur99865_2674.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000022896.
    OMAi ERVNQNG.
    OrthoDBi EOG6QRWC5.

    Enzyme and pathway databases

    BioCyci SAUR93061:GIWJ-2883-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR014710. RmlC-like_jellyroll.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Staphylococcus aureus arcR controls expression of the arginine deiminase operon."
      Makhlin J., Kofman T., Borovok I., Kohler C., Engelmann S., Cohen G., Aharonowitz Y.
      J. Bacteriol. 189:5976-5986(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN ARGININE CATABOLISM, SUBCELLULAR LOCATION, INDUCTION.
    2. "The Staphylococcus aureus NCTC 8325 genome."
      Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
      (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 8325.

    Entry informationi

    Entry nameiARCR_STAA8
    AccessioniPrimary (citable) accession number: Q2FUY1
    Secondary accession number(s): Q7X2S1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3