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Q2FUY1 (ARCR_STAA8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HTH-type transcriptional regulator ArcR
Gene names
Name:arcR
Ordered Locus Names:SAOUHSC_02964
OrganismStaphylococcus aureus (strain NCTC 8325) [Reference proteome] [HAMAP]
Taxonomic identifier93061 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Positively regulates the expression of the arcABDCR operon under anaerobic conditions, by binding to the consensus motif 5'-TGTGAN6TCACA-3', thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP. Ref.1

Subcellular location

Cytoplasm Probable Ref.1.

Induction

Induced by arginine and anaerobic growth during the stationary phase. Repressed under aerobic conditions independently of the growth phase and by glucose catabolic repression. Ref.1

Sequence similarities

Contains 1 cyclic nucleotide-binding domain.

Contains 1 HTH crp-type DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
   LigandcAMP
cAMP-binding
DNA-binding
Nucleotide-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from mutant phenotype Ref.1. Source: CACAO

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

cAMP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 234234HTH-type transcriptional regulator ArcR
PRO_0000349414

Regions

Domain155 – 22874HTH crp-type
Nucleotide binding40 – 12990cNMP
DNA binding188 – 20720H-T-H motif By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2FUY1 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: A26B08D8A1EA396E

FASTA23427,428
        10         20         30         40         50         60 
MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY FSPQESSNIY 

        70         80         90        100        110        120 
FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV NELCTALTDC TVLGLPRELM 

       130        140        150        160        170        180 
AFLCKANDDI FLTLFALIND NEQQHMNYNM ALTSKFAKDR IIKLICHLCQ TVGYDQDEFY 

       190        200        210        220        230 
EIKQFLTIQL MSDMAGISRE TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV 

« Hide

References

« Hide 'large scale' references
[1]"Staphylococcus aureus arcR controls expression of the arginine deiminase operon."
Makhlin J., Kofman T., Borovok I., Kohler C., Engelmann S., Cohen G., Aharonowitz Y.
J. Bacteriol. 189:5976-5986(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN ARGININE CATABOLISM, SUBCELLULAR LOCATION, INDUCTION.
[2]"The Staphylococcus aureus NCTC8325 genome."
Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 8325.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ566750 Genomic DNA. Translation: CAD98185.1.
CP000253 Genomic DNA. Translation: ABD31954.1.
RefSeqYP_501415.1. NC_007795.1.

3D structure databases

ProteinModelPortalQ2FUY1.
SMRQ2FUY1. Positions 31-224.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING93061.SAOUHSC_02964.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD31954; ABD31954; SAOUHSC_02964.
GeneID3921666.
KEGGsao:SAOUHSC_02964.
PATRIC19583137. VBIStaAur99865_2674.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000022896.
OMAERVNQNG.
OrthoDBEOG6QRWC5.
ProtClustDBCLSK886120.

Enzyme and pathway databases

BioCycSAUR93061:GIWJ-2883-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARCR_STAA8
AccessionPrimary (citable) accession number: Q2FUY1
Secondary accession number(s): Q7X2S1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 21, 2006
Last modified: February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families