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Protein

HTH-type transcriptional regulator ArcR

Gene

arcR

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Positively regulates the expression of the arcABDCR operon under anaerobic conditions, by binding to the consensus motif 5'-TGTGAN6TCACA-3', thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 12990cNMPAdd
BLAST
DNA bindingi188 – 20720H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

  1. cAMP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: CACAO
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

cAMP, cAMP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-2883-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator ArcR
Gene namesi
Name:arcR
Ordered Locus Names:SAOUHSC_02964
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000008816 Componenti: Chromosome

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234HTH-type transcriptional regulator ArcRPRO_0000349414Add
BLAST

Expressioni

Inductioni

Induced by arginine and anaerobic growth during the stationary phase. Repressed under aerobic conditions independently of the growth phase and by glucose catabolic repression.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02964.

Structurei

3D structure databases

ProteinModelPortaliQ2FUY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 22874HTH crp-typeAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000022896.
OMAiERVNQNG.
OrthoDBiEOG6QRWC5.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2FUY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY
60 70 80 90 100
FSPQESSNIY FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV
110 120 130 140 150
NELCTALTDC TVLGLPRELM AFLCKANDDI FLTLFALIND NEQQHMNYNM
160 170 180 190 200
ALTSKFAKDR IIKLICHLCQ TVGYDQDEFY EIKQFLTIQL MSDMAGISRE
210 220 230
TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV
Length:234
Mass (Da):27,428
Last modified:March 21, 2006 - v1
Checksum:iA26B08D8A1EA396E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ566750 Genomic DNA. Translation: CAD98185.1.
CP000253 Genomic DNA. Translation: ABD31954.1.
RefSeqiYP_501415.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD31954; ABD31954; SAOUHSC_02964.
GeneIDi3921666.
KEGGisao:SAOUHSC_02964.
PATRICi19583137. VBIStaAur99865_2674.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ566750 Genomic DNA. Translation: CAD98185.1.
CP000253 Genomic DNA. Translation: ABD31954.1.
RefSeqiYP_501415.1. NC_007795.1.

3D structure databases

ProteinModelPortaliQ2FUY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02964.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD31954; ABD31954; SAOUHSC_02964.
GeneIDi3921666.
KEGGisao:SAOUHSC_02964.
PATRICi19583137. VBIStaAur99865_2674.

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000022896.
OMAiERVNQNG.
OrthoDBiEOG6QRWC5.

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-2883-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Staphylococcus aureus arcR controls expression of the arginine deiminase operon."
    Makhlin J., Kofman T., Borovok I., Kohler C., Engelmann S., Cohen G., Aharonowitz Y.
    J. Bacteriol. 189:5976-5986(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN ARGININE CATABOLISM, SUBCELLULAR LOCATION, INDUCTION.
  2. "The Staphylococcus aureus NCTC 8325 genome."
    Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
    (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2005)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 8325.

Entry informationi

Entry nameiARCR_STAA8
AccessioniPrimary (citable) accession number: Q2FUY1
Secondary accession number(s): Q7X2S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 21, 2006
Last modified: January 7, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.