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Q2FUS6

- PCP_STAA8

UniProt

Q2FUS6 - PCP_STAA8

Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

    Catalytic activityi

    Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei78 – 781UniRule annotation
    Active sitei141 – 1411UniRule annotation
    Active sitei165 – 1651UniRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BioCyciSAUR93061:GIWJ-2942-MONOMER.

    Protein family/group databases

    MEROPSiC15.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrrolidone-carboxylate peptidaseUniRule annotation (EC:3.4.19.3UniRule annotation)
    Alternative name(s):
    5-oxoprolyl-peptidaseUniRule annotation
    Pyroglutamyl-peptidase IUniRule annotation
    Short name:
    PGP-IUniRule annotation
    Short name:
    PyraseUniRule annotation
    Gene namesi
    Name:pcpUniRule annotation
    Ordered Locus Names:SAOUHSC_03025
    OrganismiStaphylococcus aureus (strain NCTC 8325)
    Taxonomic identifieri93061 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000008816: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Pyrrolidone-carboxylate peptidasePRO_1000050139Add
    BLAST

    Proteomic databases

    PRIDEiQ2FUS6.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi93061.SAOUHSC_03025.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2FUS6.
    SMRiQ2FUS6. Positions 1-212.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C15 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2039.
    HOGENOMiHOG000242641.
    KOiK01304.
    OMAiKPNTPSM.
    OrthoDBiEOG6X1124.

    Family and domain databases

    Gene3Di3.40.630.20. 1 hit.
    HAMAPiMF_00417. Pyrrolid_peptidase.
    InterProiIPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view]
    PANTHERiPTHR23402. PTHR23402. 1 hit.
    PfamiPF01470. Peptidase_C15. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSiPR00706. PYROGLUPTASE.
    PROSITEiPS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2FUS6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHILVTGFAP FDNQNINPSW EAVTQLEDII GTHTIDKLKL PTSFKKVDNI    50
    INKTLASNHY DVVLAIGQAG GRNAITPERV AINIDDARIP DNDDFQPIDQ 100
    AIHLDGAPAY FSNLPVKAMT QSIINQGLPG ALSNSAGTFV CNHTLYHLGY 150
    LQDKHYPHLR FGFIHVPYIP EQVIGKPDTP SMPLEKIVAG LTAAIEAISN 200
    DEDLHLALGT TE 212
    Length:212
    Mass (Da):23,167
    Last modified:March 21, 2006 - v1
    Checksum:iBBC76CD8FC43ACBC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000253 Genomic DNA. Translation: ABD32011.1.
    RefSeqiYP_501474.1. NC_007795.1.

    Genome annotation databases

    EnsemblBacteriaiABD32011; ABD32011; SAOUHSC_03025.
    GeneIDi3921292.
    KEGGisao:SAOUHSC_03025.
    PATRICi19583255. VBIStaAur99865_2733.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000253 Genomic DNA. Translation: ABD32011.1 .
    RefSeqi YP_501474.1. NC_007795.1.

    3D structure databases

    ProteinModelPortali Q2FUS6.
    SMRi Q2FUS6. Positions 1-212.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93061.SAOUHSC_03025.

    Protein family/group databases

    MEROPSi C15.001.

    Proteomic databases

    PRIDEi Q2FUS6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD32011 ; ABD32011 ; SAOUHSC_03025 .
    GeneIDi 3921292.
    KEGGi sao:SAOUHSC_03025.
    PATRICi 19583255. VBIStaAur99865_2733.

    Phylogenomic databases

    eggNOGi COG2039.
    HOGENOMi HOG000242641.
    KOi K01304.
    OMAi KPNTPSM.
    OrthoDBi EOG6X1124.

    Enzyme and pathway databases

    BioCyci SAUR93061:GIWJ-2942-MONOMER.

    Family and domain databases

    Gene3Di 3.40.630.20. 1 hit.
    HAMAPi MF_00417. Pyrrolid_peptidase.
    InterProi IPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view ]
    PANTHERi PTHR23402. PTHR23402. 1 hit.
    Pfami PF01470. Peptidase_C15. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSi PR00706. PYROGLUPTASE.
    PROSITEi PS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Staphylococcus aureus NCTC 8325 genome."
      Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
      (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 8325.

    Entry informationi

    Entry nameiPCP_STAA8
    AccessioniPrimary (citable) accession number: Q2FUS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3